General health and functional improvement among patients with unstable extracapsular proximal femoral fractures managed with proximal femoral nail by using SF-36 score

Background: Proximal femoral nail is emerging as the treatment of choice for unstable extra capsular proximal femoral fractures. This study comprises of functional evaluation of the treated patients by using SF 36 score.Methods: This was a prospective hospital-based study done on 54 patients with unstable proximal femoral fractures classified according to the AO/ASIF classification system and were treated by using PFN in the department of Orthopaedics DRPGMC, Tanda. Functional outcome was assessed by using SF-36 score on, 14th postoperative day, at three months and six months.Results: Our study has mean scores of short form-36 subscales as physical function 70.6, role limitation due to physical health 68.1, role limitation due to emotional health 90, energy/fatigue 66, emotional wellbeing 78, social functioning 67.7, pain 75 and general health 73.3.Conclusions: The results of this study confirm that intramedullary nailing with the use of a PFN in unstable proximal femoral fractures is a safe method. A significant change was seen in quality of life postoperatively as evidenced by various scores used in present study. Weaknesses of this study include a short follow-up period and the inclusion of a small study group

JAK2V617F: Is It Sufficient as a Single Player in Splanchnic Venous Thrombosis?

Splanchnic venous thrombosis (SVT) includes thrombosis of the hepatic, portal, and mesenteric venous system. Myeloproliferative neoplasms (MPNs) are important factors of SVT in adults. Addition of JAK2V617F mutation in WHO criteria for diagnosis of MPNs has made this test a useful tool for diagnosis. JAK2 is an intracytoplasmic tyrosine kinase that plays a critical role in signal transduction from multiple hematopoietic factor receptors. The mutation is found frequently in patients with SVT; many such patients have no other manifestations of an MPN. Although the correlation of JAK2V617F mutation with thrombotic risk in MPNs has been shown in many studies, the impact of presence of additional thrombophilic factors in these cases is yet not known. As the management of MPNs remains highly dependent on the patient’s thrombotic risk, it is important to assess the thrombotic risk factors in detail. Here, we report two cases of JAK2V617F positive MPN who also had other thrombophilic conditions and presented with recurrent thrombosis

A COMPARATIVE CLINICAL STUDY ON WITHDRAWAL SYMPTOMS OF MADATYAYA WITH PUNARNAVADI GHRITA

The disease caused by the excessive and regular us of Madya is called Madatyaya which can be correlated to Alcoholism on basis of withdrawal symptoms. In present world of modernisation the unlimited pressure of carrier and livelihood the youth and middle age generation easily get addicted to alcohol which is a big hazard to social and economic development and deteriorates the health services. The addicted alcoholic patients cannot come out of the condition easily because the withdrawal symptoms. The present study has been done to manage the withdrawal symptoms of Madatyaya. In this study the clinical efficacy of medicine given by the Drug De-addiction centre and Punarnavadi Ghritt was compared on 20 patients of withdrawal symptoms divided in 2 groups i.e. A and B for 30 days. Hb gm%, TLC, DLC, ESR, LFT were also done to assess the efficacy of the drug. Group-A was treated with the medicine provided by the Drug De-addiction centre, which was statistically significant (P<0.05) in subjective parameters. Group-B treated with Punarnavadi Ghritta, showed significant (P<0.05) results in objective parameters. Follow-up was on 15th day and after treatment. Our study revealed that the test drug Punarnavadi Ghritta is more effective on objective parameters than modern medicine which is more effective on subjective parameters in treatment of withdrawal of Madatyaya. Hence the trial drug can be used as a medicine to improve laboratory findings for patients of withdrawal symptoms of Madatyaya

Effect of growing media, pinching and paclobutrazol on growth and flowering of Barleria cristata for suitability as pot plant

A study was conducted to see the effect of three growing media (soil from natural habitat, soil from natural habitat and FYM (2:1), v/v and soil, sand and FYM (2:1:1), three pinching treatments (No pinch, single pinch and double pinch) and paclobutrazol (0, 75, 150 ppm) on growth and flowering of seedlings as well as vegetatively propagated (rooted stem cuttings) of Phillipines violet or blue bell barleria (Barleria cristata L.). Plants raised through seeds and rooted cuttings differed significantly among themselves for various growth and flowering parameters. Plants raised under both methods of propagation showed optimum plant height (1.5 to 2.5 times to the height of the pot) when grown in soil from natural habitat and FYM with single and double pinching in absence of application of paclobutrazol for growing as pot plant. Seedlings recorded maximum number of secondary side shoots (20.58), leaves (177.42), flower clusters (16.17), flowers (23.58)/plant when grown in soil from natural habitat and FYM with double pinching and with the application of 75 ppm paclobutrazol and seed raised plants showed early visible bud formation and flowering when grown in all growing media without pinching and application of 75 ppm paclobutrazol. However, the cutting raised plants recorded maximum number, of secondary side shoots (16.00), leaves (171.67), flower clusters (17.83), flowers (24.42)/plant when grown in soil from natural habitat and FYM with double pinching and with the application of 75 ppm paclobutrazol. Seed raised plants showed better results in case of plant height, length of primary side shoots and plant spread than cutting raised plants while cutting raised plants recorded early visible bud formation and flowering and maximum number of flower clusters/plant than seed raised plants. Based on the findings of present investigations, seed raised Barleria cristata. plants grown in pots containing soil from natural habitat added with FYM (2:1, v/v), double pinching and application of 75 ppm paclobutrazol is recommended for better growth and flowering

Effect of covering materials on off-season cut flower production in chrysanthemum (Dendrathema grandiflora)

Studies on the effect of covering material on off-season cut flower production of chrysanthemum (Dendranthema grandiflora Tzvelev) were carried out at the experimental farm of the Department of Floriculture and Landscape Architecture, Dr Yashwant Singh Parmar University of Horticulture and Forestry, Nauni, Solan, Himachal Pradesh, during 2011 in naturally ventilated polyhouse. The experiment was carried out using three types of covering materials(viz. tarpaulin, high density polyethylene (HDPE) and black sateen cloth) and four cultivars each of standard (Purnima, Yellow Star, Tata Century and White Star) and spray (Ajay, Birbal, Nanako and White Bouquet) varieties. Findings revealed that HDPE was the best alternative covering material to tarpaulin as optimum plant height (83.33 cm), plant spread (40.54 cm), maximum number of cut stems (4.21), duration of flowering (33.54 days) and earliest flower bud formation (91.07 days) and flowering were obtained in plants under HDPE. Flowering was earlier under controlled photoperiod than natural photoperiod. Peak flowering was earliest (140.36 days) in plants under HDPE* cover as compared to plants under natural photoperiodic conditions which took maximum number of days (176.19), to come to peak flowering. The varieties were assigned to different response group under controlled photoperiodic conditions with HDPE. All the varieties tested were found suitable for off-season flower production

Effect of planting dates on growth, flowering and seed production of garland chrysanthemum (Chrysanthemum coronarium)

A field experiment carried out to study the effect of planting dates on growth, flowering and seed production of garland chrysanthemum (Chrysanthemum coronarium L.) under mid-hills of Himachal Pradesh during 2010-11 and 2011-12 exhibited significant influence on growth, flowering and seed production. Planting was done at an interval of 15 days starting from 17 September in both the years with planting dates as; 17 September, 2 October, 17 October, 1 November, 16 November and 1 December. The maximum plant height (120.29 cm), number of side stems/plant (16.23), early flowering (95.08 days), duration of flowering (41.43 days), number of flowers/stem (21.98), number of heads/plant (308), number of seeds/head (243.95), seed yield/plant (77.40 g) and 1 000 seed weight (1.67 g) were recorded when planting was done on 17 September. However head formation was earliest (158.53 days) in 1 December planting

Variation in growth, flowering and seed yield of satin flower (Godetia grandiflora) planted on different dates

The effect of climatic conditions and planting dates on growth, flowering and seed production of satin flower (Godetia grandiflora Lindl.) under mid hill conditions of Himachal Pradesh during 2010-11 and 2011-12 were investigated. Plantings were done at an interval of 15 days starting from 17 September in both the years with planting dates as; 17 September, 2 October, 17 October, 1 November, 16 November and 1 December under randomized block design. The maximum plant height (68.35 cm), plant spread (50.66 cm), stem length (58.38 cm), duration of flowering (33.91 days), number of flowers/stem (central and side; 110.08 and 15.74), number of capsules/plant (327.50), number of seeds/capsule (90.69) and seed yield/plant (9.18 g) were recorded when planting was done on 17 September. However, earliest visible flower bud formation (121.36 days), days to flowering (151.53) and capsule formation (205.42 days) were observed in 1 December planting

JAK2V617F: Is It Sufficient as a Single Player in Splanchnic Venous Thrombosis?

Splanchnic venous thrombosis (SVT) includes thrombosis of the hepatic, portal, and mesenteric venous system. Myeloproliferative neoplasms (MPNs) are important factors of SVT in adults. Addition of JAK2V617F mutation in WHO criteria for diagnosis of MPNs has made this test a useful tool for diagnosis. JAK2 is an intracytoplasmic tyrosine kinase that plays a critical role in signal transduction from multiple hematopoietic factor receptors. The mutation is found frequently in patients with SVT; many such patients have no other manifestations of an MPN. Although the correlation of JAK2V617F mutation with thrombotic risk in MPNs has been shown in many studies, the impact of presence of additional thrombophilic factors in these cases is yet not known. As the management of MPNs remains highly dependent on the patient’s thrombotic risk, it is important to assess the thrombotic risk factors in detail. Here, we report two cases of JAK2V617F positive MPN who also had other thrombophilic conditions and presented with recurrent thrombosis

Lead optimization for promising monoamine oxidase inhibitor from eugenol for the treatment of neurological disorder: synthesis and in silico based study

Abstract Natural based inhibitors of monoamine oxidase are promising drug candidates for the treatment of several neurodegenerative and neuropsychological disorders including depression, anxiety, Parkinson’s disease and Alzheimer’s disease. In the present study we designed and synthesized the eugenol based derivatives and investigated them for human MAO inhibitory potential as promising candidates for therapeutics of neurological disorders. Moreover, radical scavenging activity of designed derivatives was tested by and H2O2 and DPPH scavenging methods. Eugenol based derivatives were designed and synthesized for human MAO inhibitory action. The in silico and in vitro models were utilized for the evaluation of hMAO inhibition. The insight into molecular interactions among the compounds and both hMAO-A and hMAO-B active site was achieved by molecular docking studies. The two spectrophotometric titrations techniques were used to evaluate antioxidant potential. Compounds 5b and 16 were found as most active hMAO-A inhibitors with IC50 values of 5.989 ± 0.007 µM and 7.348 ± 0.027 µM respectively, through an appreciable selectivity index value of 0.19 and 0.14 respectively. In case of hMAO-B inhibition compounds 13a and 13b were found as most active hMAO-B inhibitors with IC50 values of 7.494 ± 0.014 µM and 9.183 ± 0.034 µM receptively and outstanding value of selectivity index of 5.14 and 5.72 respectively. Radical scavenging assay showed that compounds 5b, 5a, 9b, 9a were active antioxidants. The findings of present study indicated excellent correlation among dry lab and wet lab hMAO inhibitory experiments. Interestingly, the compounds exhibiting better MAO inhibition activity was also appeared as good antioxidant agents