CT-IGFBP-4 as a Predictive Novel Biomarker of Ischemic Cardiovascular Events and Mortality: A Systematic Review

Background and objective: Numerous novel biomarkers have been proposed for the early diagnosis of cardiovascular diseases. Measurement of the carboxyl-terminal (CT) fragment of IGFBP-4, the CT-IGFBP-4, has shown promising efficacy in cardiac risk assessment in various studies. We performed a systematic review of studies that accessed the utility and predictability of CT-IGFBP-4 in different ischemic cardiovascular events. Methods: The electronic databases PubMed, medRxiv, ScienceDirect, and Google Scholar were searched for relevant literature from inception to the 10th of December, 2021. Thus, retrieved literature was screened by title and abstract, followed by full-text screening based on the eligibility criteria. The risk of bias was accessed using the quality in prognostic studies (QUIPSs) tool. The data on cardiovascular outcomes about CT-IGFBP-4 levels were studied and the results were synthesized. Results: Five studies with a total of 1,417 participants were included in our study. The studies reported a low risk of bias. The mean age of the participants was 66.14 and more than 65% were males. Elevated CT-IGFBP-4 levels were associated with poor cardiovascular outcomes and increased mortality in severely ill patients. In contrast, there were no significant findings in the case of stable patients. Sandwich ELISA using lithium-heparin plasma provided a better detection limit of 0.15 ng/ml, low cross-reactivity ( Conclusion: CT-IGFBP-4 is an efficient biomarker for the prediction of MACE and mortality in patients with severe ischemic cardiovascular events

Late Holocene Glacier Dynamics in the Miyar Basin, Lahaul Himalaya, India

Detailed field mapping of glacial and paraglacial landforms and optical dating from these landforms are used to reconstruct the early Holocene glaciation in the semi-arid region of Miyar basin, Lahaul Himalaya. The study identifies three stages of glaciation, of decreasing magnitude and termed, from oldest to youngest, the Miyar stage (MR-I), Khanjar stage (KH-II), and Menthosa advance (M-III). The oldest glacial stage (MR-I) has been established on the basis of detailed geomorphological evidence such as U-shaped valley morphology, trimlines, and truncated spurs. It is speculated to be older than the global Last Glacial Maximum (gLGM) based on the magnitude of ΔELA (Equilibrium-Line Altitude, 606m). No evidence of glacier expansion recorded from the basin correlates with the period of the gLGM. The second stage (KH-II) is well represented by extensive depositional features such as lateral and terminal moraines, drumlins, and lacustrine fills that have been constrained within 10 ± 1 to 6.6 ± 1.0 ka (Optically stimulated luminescence—OSL—ages), dating it to the early Holocene advance following the Younger Dryas cooling event. Exceptionally young glacial records of expansion are limited within a few hundred meters of the present termini of tributary glaciers and correlates with the 18th-century cooling event. Records of this glacial advance, termed the Menthosa advance, are clearly noticed in some tributary valleys

Addition compounds of copper(II) and cobalt(II) monochloroacetates with some oxygen donor ligands

This article does not have an abstract

Addition of compounds of alkoxy antimony(V) tetrachlorides with some phosphoryl and amine-oxide ligands

An adduct of Tin(IV) trichloride (2-chloroethoxide) (A') with 2-chloroethylalcohol(A) has been prepared. Complexes of A' with amide, dimethylurea, dimethylsulphoxide, primary, secondary and tertiary amines and αα'-dipyridyl have been prepared. I.R. spectra of the complexes in 4000-250 cm<SUP>−1</SUP> spectral region have been examined to throw some light on their structure

A Study on Effect of Omega 3 Fatty Acids in Hypertriglyceridemia

, was highly significant after 8 weeks of treatment. HDL-cholesterol levels increased highly significantly (37.40±3.96 vs. 39.14±3.40 mg/dl; p&lt;0.001).Total cholesterol also decreased highly significantly (221.71±25.22 vs. 213.97±22.31 mg/dl; p&lt;0.001

Reconstruction of post-little ice age glacier recession in the Lahaul Himalaya, north-west India

Understanding past glaciation and deglaciation is vital for assessing present-day glacier dynamics and response to climate change. We focus on reconstructing past glacier fluctuations in Lahaul, north-west India, a region located between arid Ladakh and the humid the Pir-Panjal range. We focus specifically on six glaciers in the Miyar and Thirot catchments of varying size, aspect and debris cover. To reconstruct past terminus fluctuations of these glaciers, we used repeat terrestrial photography and historical archives as data sets and mapped the terminus positions and latero-terminal moraines in the field along with glacier terminus mapping from high to medium resolution satellite images (e.g. Corona, Hexagon, Landsat and LISS IV). Results show that since the little ice age, all the studied glaciers have experienced terminus retreat and area loss, with average values of 1.46 and 0.9 km2, respectively. Precipitation data show a statistically significant decreasing trend during the last century with an increasing trend in annual average maximum (Tmax) and minimum (Tmin) temperature. This warming trend is more statistically significant for Tmin. Although total ice loss at the six studied glaciers is considerable (5.48 km2), this varies both spatially (i.e. from glacier to glacier) and temporally. We attribute this variability to topographic controls such as glacier hypsometry and another non-climatic factor, i.e. varying degree of debris cover

Decadal terminus position changes and ice thickness measurement of Menthosa Glacier in Lahaul region of North-Western Himalaya

Glacier ice-thickness measurement and distribution is one of the essential variables to assess present status of glacier-water equivalent and its volumetric reserve as well as to model the future glacier dynamics under the climate changing scenario. Yet, substantial gaps in ice thickness information exist for the Himalayan glaciers. The present study provides a long-term assessment (1965–2016) of recessional and area change patterns, as well as the detailed field-based (2016–2017) Ground Penetrating Radar(GPR), derived ice-thickness measurement of the Menthosa Glacier, Lahaul Himalaya. Additionally, the study examines whether the modelled ice thickness from remote sensing data is consistent with the field-based GPR measurement and how can it be improved. The extensive field surveys coupled with the multi-temporal high (Corona KH-4A) to medium resolution (Landsat Enhanced Thematic Mapper+ (ETM+)/Operational Land Imager (OLI), Sentinel 2A-Multispectral Instrument (MSI)) remote sensing data and cross-sectional GPR surveyed profile measurements have been used to examine past half a century (1965–2016) glacier fluctuation and the recent ice-thickness estimations, respectively. The results show that the Menthosa Glacier receded by 301.5 ± 19.2 m during the past half a century (1965–2016) with an average annual retreat of 5.9 ± 0.4 m a−1, whereas glacier lost 0.09 km2 ice in the frontal section. Field measurement over the past one decade (2006–2017) also conforms to a continuous recessional pattern and substantial glacier degeneration particularly the extensive surface lowering and significant appearance of ice-cliffs in the ablation and lateral zones over this period. The GPR measurements (2017) show the minimum glacier ice thickness of 24 meters at 4691 m a.s.l. (in the lower part of ablation area) and maximum glacier ice thickness of 55 meters measured at 4758 m a.s.l. (in the upper left-side tributary part of ablation area). Moreover, the modelled ice thickness derived from remotely sensed data is having Root Mean Square Error (RMSE) between 38 to 72 ± 10 m as compared with GPR measured ice thickness