IL-1β (A) and IL-18 (B) production by monocytes.

<p>Monocytes from pregnant women with preeclampsia (PE), normotensive pregnant women (NT) and non-pregnant women (NP), were cultured in the presence (MSU⁺) or absence (MSU^-) of monosodium urate. Results are shown as median. *<i>P<0</i>.<i>05</i> shows significant difference between MSU^- groups; ⁺<i>P<0</i>.<i>05</i> shows significant difference between MSU⁺ groups; # <i>P<0</i>.<i>05 vs</i> MSU⁺.</p

Gene expression of NLRP1 (A), NLRP3 (B) and caspase-1 (C) by monocytes.

<p>Monocytes from pregnant women with preeclampsia (PE), normotensive pregnant women (NT) and non-pregnant women (NP), were cultured in the presence (MSU⁺) or absence (MSU^-) of monosodium urate. Expression of caspase-1 (D) by monocytes from non-pregnant women treated with 50 μM or 200 μM of Glybenclamide and cultured in the presence (MSU⁺) or absence (MSU^-) of monosodium urate. Results are shown as median. *<i>P<0</i>.<i>05</i> shows significant difference between MSU^- groups; ⁺<i>P<0</i>.<i>05</i> shows significant difference between MSU⁺ groups; # <i>P<0</i>.<i>05vs</i>MSU⁺; ^●<i>P<0</i>.<i>05</i>(MSU^-<i>vs</i>MSU^- + G200), (MSU50 <i>vs</i> MSU50+G200), (MSU100 <i>vs</i> MSU100+G200).</p

Gene expression of IL-1β (A) and IL-18 (B) by monocytes.

<p>Monocytes from pregnant women with preeclampsia (PE), normotensive pregnant women (NT) and non-pregnant women (NP), were cultured in the presence (MSU⁺) or absence (MSU^-) of monosodium urate. Expression of IL-1 β (C) by monocytes from non-pregnant women treated with 50 μM and 200 μM of Glybenclamide, in the presence (MSU⁺) or absence (MSU^-) of monosodium urate. Results are shown as median.*<i>P<0</i>.<i>05</i> shows significant difference between MSU^- groups; ⁺<i>P<0</i>.<i>05</i> shows significant difference between MSU⁺ groups; # <i>P<0</i>.<i>05vs</i>MSU⁺; ^●<i>P<0</i>.<i>05</i> (MSU^-<i>vs</i>MSU^- + G200), (MSU50 <i>vs</i> MSU50+G200), (MSU100 <i>vs</i> MSU100+G200).</p

TNF-α production by monocytes.

<p>Monocytes from pregnant women with preeclampsia (PE), normotensive pregnant women (NT) and non-pregnant women (NP), were cultured in the presence (MSU⁺) or absence (MSU^-) of monosodium urate. Results are shown as median. *<i>P<0</i>.<i>05</i> shows significant difference between MSU^- groups; ⁺<i>P<0</i>.<i>05</i> shows significant difference between MSU⁺ groups; # <i>P<0</i>.<i>05 vs</i> MSU⁺.</p