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Abóbora-gila (cucurbita ficifolia), uma hortaliça pouco convencional cultivada no Rio Grande do Sul.
bitstream/item/78979/1/documento-320.pd
Letter regarding article by Coronel et al, ''right ventricular fibrosis and conduction delay in a patient with clinical signs of Brugada syndrome: a combined electrophysiological, genetic, histopathologic, and computational study''
Letter regarding article by Coronel et al, ''right ventricular fibrosis and conduction delay in a patient with clinical signs of Brugada syndrome: a combined electrophysiological, genetic, histopathologic, and computational study'
When is genetic testing useful in patients suspected to have inherited cardiac arrhythmias?
PURPOSE OF REVIEW:
In this article, we will review the appropriate use of genetic testing in those patients suspected to have inherited arrhythmogenic diseases, with specific focus on the indications for testing and the expected probability of positive genotyping.
RECENT FINDINGS:
Important advances have been made in the identification of new genes, associated mutations, and polymorphisms that modulate susceptibility of acquired arrhythmias. We will examine the most recent advances relevant to the rational application of genetic analysis, guided by genotype-phenotype correlations derived from disease and patient-specific evaluation, as well as discussing novel technologies and recently published cost-effectiveness data.
SUMMARY:
Genetic analysis can be performed to identify the molecular substrate in those patients suspected to be affected by an inherited arrhythmogenic disease; however, the clinical usefulness of this information is often not straightforward. We hope to emphasize the concept that there is a significant difference in the impact of genetic testing within the various arrhythmogenic disorders, and the benefit of accessing genetic testing is not the same in all patients. The resultant integration between the expected yield of genetic screening and cost may allow the formation of criteria to prioritize access for those who could derive the most clinical benefit
Inherited calcium channelopathies in the pathophysiology of arrhythmias.
Regulation of calcium flux in the heart is a key process that affects cardiac excitability and
contractility. Degenerative diseases, such as coronary artery disease, have long been
recognized to alter the physiology of intracellular calcium regulation, leading to contractile
dysfunction or arrhythmias. Since the discovery of the first gene mutation associated with
catecholaminergic polymorphic ventricular tachycardia (CPVT) in 2001, a new area of interest in
this field has emerged-the genetic abnormalities of key components of the calcium regulatory
system. Such anomalies cause a variety of genetic diseases characterized by the development
of life-threatening arrhythmias in young individuals. In this Review, we provide an overview of the
structural organization and the function of calcium-handling proteins and describe the
mechanisms by which mutations determine the clinical phenotype. Firstly, we discuss mutations
in the genes encoding the ryanodine receptor 2 (RYR2) and calsequestrin 2 (CASQ2). These
proteins are pivotal to the regulation of calcium release from the sarcoplasmic reticulum, and
mutations can cause CPVT. Secondly, we review defects in genes encoding proteins that form
the voltage-dependent L-type calcium channel, which regulates calcium entry into myocytes.
Mutations in these genes cause various phenotypes, including Timothy syndrome, Brugada
syndrome, and early repolarization syndrome. The identification of mutations associated with
'calcium-handling diseases' has led to an improved understanding of the role of calcium in
cardiac physiology
Transferibilidade de marcadores microssatélites de coco (Cocos nucifera) para butiá (Butia odorata)
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Previous issue date: 2013-09-17201
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