Unveiling The Critical Role Of CYP2C19 Gene In Precision Medicine Through Bibliometric Analysis

The CYP2C19 gene is pivotal in precision medicine, influencing the efficacy of therapeutic approaches, particularly in pharmacokinetics and pharmacogenomics. This study aims to extensively chart the research landscape of the CYP2C19 gene, delineating crucial interconnections among various research themes, and identifying significant studies and future research directions in precision medicine, with a focus on CYP2C19. An extensive literature review was conducted, adhering to PRISMA guidelines for reference curation and employing bibliometric analysis for research mapping. A total of 2,293 documents were retrieved from the Scopus database using 'precision' as the keyword. After meticulous refinement and data preparation, 1,829 of these publications were deemed suitable for in- depth analysis. The study reveals a notable increase in CYP2C19-related research from 2019 to 2022. The bibliometric analysis identified four primary clusters: Clopidogrel, Pharmacogenomics-Pharmacokinetics, Cytochrome P450, and Voriconazole. The Voriconazole cluster exhibited a unique divergence, indicating opportunities for collaborative research. Key strategic areas identified include valproic acid, antidepressants, and herb-drug interactions. Our findings provide valuable insights into the CYP2C19 gene research, offering a foundation for guiding future research in precision medicine