Searching for Gravitational Waves with a Geostationary Interferometer

We analyze the sensitivities of a geostationary gravitational wave interferometer mission operating in the sub-Hertz band. Because of its smaller armlength, in the lower part of its accessible frequency band ($10^{-4} - 2 \times 10^{-2}$ Hz) our proposed Earth-orbiting detector will be less sensitive, by a factor of about seventy, than the Laser Interferometer Space Antenna (LISA) mission. In the higher part of its band instead ($2 \times 10^{-2} - 10$ Hz), our proposed interferometer will have the capability of observing super-massive black holes (SMBHs) with masses smaller than $\sim 10^{6}$ M$_{\odot}$. With good event rates for these systems, a geostationary interferometer will be able to accurately probe the astrophysical scenarios that account for their formation.Comment: 33 pages, 9 eps figure

A multiple resistance locus on chromosome arm 3BS in wheat confers resistance to stem rust (Sr2), leaf rust (Lr27) and powdery mildew

Sr2 is the only known durable, race non-specific adult plant stem rust resistance gene in wheat. The Sr2 gene was shown to be tightly linked to the leaf rust resistance gene Lr27 and to powdery mildew resistance. An analysis of recombinants and mutants suggests that a single gene on chromosome arm 3BS may be responsible for resistance to these three fungal pathogens. The resistance functions of the Sr2 locus are compared and contrasted with those of the adult plant resistance gene Lr34

Practical considerations in ovarian cancer chemotherapy

Epithelial ovarian cancer remains the most lethal gynecologic malignancy despite advances in treatment. The standard management generally involves a combination of surgical tumor debulking and chemotherapy. Over the decades, chemotherapy for ovarian cancer has evolved and currently involves a combination of intravenous platinum and taxane chemotherapy. Over the past decade, three randomized phase III trials have been reported, and all have demonstrated a significant survival advantage for intraperitoneal compared with intravenous chemotherapy. However, there are potential barriers and controversies related to the administration of intraperitoneal chemotherapy in ovarian cancer patients. In this review, we discuss the evolution and current management considerations of chemotherapy for the treatment of epithelial ovarian cancer

Debating some past and present research frameworks and methodologies in history on places and their peoples in South Africa

Histories regarding places and their peoples in South Africa can be traced to the early days of History being practised as an academic discipline. However, practising this form of history under (and outside) the flag of regional history was formalised only in the mid seventies, while informalised research practices in the field continued as methods complementing various schools of thought. Narrowly perceived local histories were considered as inclusive of the formalised and informalised regional history practices as knowledge contributing towards a broader understanding of a (geographically defined/ politically demarcated) region. Of interest is not only the historiography in this field (of which a few pointers are shared in this discussion) but some of the frameworks and methods to research and to record regional histories that have been used in the past. Equally of interest are the ways in which these frameworks and methods are still applied and thought of as dynamic and progressive to assist the historian to progress towards producing and packaging research as part of a comprehensive, all inclusive approach in creating knowledge as regional history studies. In South Africa, an extensive debate on how regional history studies should be broadly defined and understood when undertaking research, still falls short. This is due to the variety, diversity and complexity of knowledge contributing to the pool of information that should be packaged as regional history studies. To contibute towards a framework of understanding and packaging knowledge in this field of meaning to regional history studies, the reader is further exposed to an extended structure of perhaps understanding and doing research in this field: a field that has always been regarded as having the potential to be both integrative and multidisciplinary by nature. Yet its integrative analytical abilities also rest on the outcome of narrow-defined histories done on spaces and places before it is possible to embark on bigger research analyses in, for example, the spirit of modern social history applications to regional history studies. This discussion on ways to understand the limited past and present of regional studies (historiographically and methodologically) in South Africa is offered to encourage further debate.10.1080/17532523.2013.857095http://dx.doi.org/10.1080/17532523.2013.85709