RecA homology search is promoted by mechanical stress along the scanned duplex DNA

A RecA–single-stranded DNA (RecA–ssDNA) filament searches a genome for sequence homology by rapidly binding and unbinding double-stranded DNA (dsDNA) until homology is found. We demonstrate that pulling on the opposite termini (3′ and 5′) of one of the two DNA strands in a dsDNA molecule stabilizes the normally unstable binding of that dsDNA to non-homologous RecA–ssDNA filaments, whereas pulling on the two 3′, the two 5′, or all four termini does not. We propose that the ‘outgoing’ strand in the dsDNA is extended by strong DNA–protein contacts, whereas the ‘complementary’ strand is extended by the tension on the base pairs that connect the ‘complementary’ strand to the ‘outgoing’ strand. The stress resulting from different levels of tension on its constitutive strands causes rapid dsDNA unbinding unless sufficient homology is present

The doctrines of the law of contracts : in their principal outlines, stated, illustrated, and condensed /

Includes bibliographical references and indexMode of access: Internet

Commentaries on the criminal law /

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Commentaries on the law of marriage and divorce : with the evidence, practice, pleading, and forms : also of separations without divorce, and of the evidence of marriage in all issues /

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Presidential Conflict of 1876 pamphlet cover

This is the title page to a 7-page publication, which reads: "Presidential Question. Supplement to 'A Legal View of the Presidential Conflict of 1876.' By J. P. Bishop, of the Cleveland Bar. Cleveland, O.; Printed By Fairbanks & Co., Herald Office., 1877." This conflict revolved around the manner of counting the electoral votes and the extent of the power of Congress over settling the dispute of who won the election of 1876 between Rutherford B. Hayes and Samuel Tilden. Tilden had won the popular vote by 51 to 49 percent but lost the electoral votes 184-185 with 20 being uncounted

New criminal procedure ; or, New commentaries on the law of pleading and evidence and the practice in criminal cases /

v. 1. General and elementary, complete in itself -- v. 2. Specific offences and their incidentsMode of access: Internet

Prosecution and defense; practical directions and forms for the grand-jury room, trial court, and court of appeal in criminal causes, with full citations of precedents from the reports and other books,

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