4 research outputs found
Do plasma D-dimer levels correlate with disease stage in colonic carcinoma?
Background: Hemostasis is deeply involved in tumour growth,
angiogenesis and metastasis. Patients with cancer may harbor many
alterations of hemostasis and these are multifaceted. The hemostatic
changes have been correlated with bulk of tumour and overall patient
survival. Aim: To assess the role of plasma D-dimer levels in
correlating with the stage of the disease in patients with colonic
carcinoma. Setting and Design : This study was a prospective study.
Materials and Methods : Sixty-six cases with biopsy-proven diagnosis of
adenocarcinoma colon over a period of two years were included. The
baseline coagulation tests like platelet count, prothrombin time,
activated partial thromboplastin time and plasma D-dimer levels were
measured preoperatively in all cases. Results: The percentage of cases
with increased D-dimer and fibrin degradation products (FDP) values
were higher in the advanced disease when compared to limited disease.
Statistical Analysis: Chi square test showed statistically significant
difference when the results of D-dimer and FDP were compared across the
four stages. When the results were compared between limited and
advanced disease by the chi square and the Mann Whitney U test, they
were found to be statistically significant. ( P < 0.05)
Conclusion: This study shows that a direct correlation exists between
D-dimer levels and disease stage in colorectal cancer and therefore
D-dimer may provide useful supplementary information to the disease
stage in colonic carcinoma
The Past and Present of Transfusion Medicine
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