Intelligent System For Brain Disease Diagnosis Using Rotation Invariant Features And Fuzzy Neural Network

The characteristic features of the magnetic resonant image (MRI) for Alzheimer’s patient’s brain image and normal image can be distinguished in terms of dimensional features with the help of wavelet decomposition. From the literature review, it is observed that when datasets used are a combination of the MR images having a very mild cognitive impairment and mild cognitive impairment, the performance of the classifier reduces. Because the features of this kind of MR image are difficult to distinguish from normal brain images. To solve this problem, the lossless feature extraction method along with the feature reduction method having a selection approach is suggested as a solution here. In this paper, the 12 directional, rotation invariant two-dimensional discrete-time continuous wavelet transform (R-DTCWT) and a genetic algorithm (GA) are used for feature selection and feature vector size reduction. The fuzzy neural network (FNN) which is suitable for pattern recognition is used here. The FNN with and without feature reduction is evaluated for identification of combinational dataset, shows satisfactory performance over an artificial neural network (ANN), probabilistic neural network (PNN) classifiers. This method is compared with other state of algorithm to prove the enhanced performanc

Relapsing cytomegalovirus infection in solid organ transplant recipients

Efforts to prevent relapsed cytomegalovirus (CMV) disease among solid organ transplant (SOT) recipients present clinical challenges. Historically, SOT recipients treated with short courses of ganciclovir, without documented clearance of viremia, had relapse rates of 23–33%. Current treatment often includes much longer courses of valganciclovir, and persistence of viremia at the end of treatment is rare. We sought to determine the rate and risk factors for relapse under those treatment conditions. Records of 1760 SOT recipients from January 2003 to June 2007 were reviewed; 105 cases of CMV viremia were identified. Relapse occurred in 20/105 (19%); 50% had end-organ disease at the time of relapse. Most patients received approximately 3 months of valganciclovir. Clearance of viremia was documented in 19/20 patients with relapse. Multivariable analysis identified receipt of a thoracic organ and diabetes mellitus as risk factors for relapse. Despite long treatment courses with valganciclovir and documented clearance of viremia, CMV relapse remains common among SOT recipients. Better understanding of the epidemiology of CMV among SOT recipients and validation of risk factors for disease relapse should be the focus of future prospective trials. Such trials should include different treatment durations and extended monitoring for relapse.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73013/1/j.1399-3062.2009.00443.x.pd

Ephedrine: direct, indirect or mixed acting sympathomimetic?

Ephedrine is the principal alkaloid that is responsible for the physiological effects of herb ephedra. This herb is found in literature of India and China since ancient times because of its effectiveness as an anti-asthmatic. Ephedrine is classified as sympathomimetic drug. Despite extensive work in this field, the mechanism of action of ephedrine remains controversial. Initial studies classified ephedrine as indirectly acting sympathomimetic, subsequent studies showed ephedrine acts by mixed action by releasing noradrenaline and by acting directly on receptors. However, few recent studies on rat have shown predominant direct action on adrenergic receptors. Hence, there is marked controversy existing whether ephedrine is directly, indirectly or mixed acting drug

Core Outcome Measures for Adults with Neurologic Conditions: Pilot Implementation in Hospital-Based Outpatient Clinic.

Purpose: To describe a pilot implementation project of 3 of the core neuro outcome measures (OMs) within a small outpatient clinic. Description: OMs provide standardized methods to track patient progress and functional status across levels of care. As the PT profession continues implementing standardized and evidence-based clinical practice guidelines (CPGs) to reflect expertise in the movement system, consistent use of OMs is crucial.1-3 A core set of OMs (COMs) CPG was developed for adults with neurologic conditions; tools to facilitate its use are being produced through the Academy of Neurologic PT (ANPT).4-6 PTs from new grads to clinical specialists should have adequate exposure to COMs and be able to administer them competently.7 Components of DPT education should be upheld once in the clinic. This capstone residency project is helping bridge that gap, bringing didactic and skills training into the clinic to refresh PTs’ OM exposure and facilitate standard and consistent use. Summary of Use: Needs assessment identified that the clinic (10-15 therapists) was not equipped to use COMs according to ANPT recommendations, and OMs were being used inconsistently. However, staff expressed willingness to begin adopting the CPG recommendations. Clinicians were provided ANPT administration guides and electronic medical record (EMR) documentation phrases. To introduce the CPG and COMs, an education session was given emphasizing recommended COM use, standardization of methods and interpretations, and group work for clinical decision-making with certain patient presentations. The session concluded with a departmental discussion on barriers to using OMs and a plan to address them, with the goal for intentional and consistent use beginning with 3 of the COMs. The department was equipped with a binder with laminated copies of ANPT guides, and the clinic was set up to standardize COM administration. For lab training, clinicians were provided copies of the 3 ANPT guides and a competency checklist, and each OM was demonstrated by the resident. During the lab, clinicians role-played alternating as therapist, patient, and observer for each OM to complete the checklist. Next steps of roll-out are currently in progress, beginning with a 5-week period to collect data, followed by data analysis. Implementation of the measures will occur during the 5 weeks, tracking frequency of OM use, documentation in the EMR, and incorporation into the plan of care as collected through a chart audit tool and weekly check-ins. It will also include a subjective pre/post survey to assess clinician learning outcomes and perceptions. Importance to Members: Barriers to OM administration are clinic-wide, and changing practice patterns may often be met with resistance.5,6,8-11 This pilot project may reflect a feasible way to standardize implementation of the COMs into hospital-based outpatient clinics in a way that is not overwhelming to clinicians nor overtly costly to management. This type of standardized OM implementation may also be able to aid in nation-wide outcomes tracking

Core Outcome Measures for Adults with Neurologic Conditions: Pilot Implementation in Hospital-Based Outpatient Clinic.

This residency capstone project’s objective was implementation of 3 of the core neuro outcome measures within a small outpatient clinic, as they were being used inconsistently and heterogeneously. The project included 3 phases: preparation/development, education, and implementation, followed by analyzing and reporting on the project’s and resident’s outcomes

Aromatic Hydrazide Compounds that Inhibit the Growth of Mycobacterium Tuberculosis

Aims: To demonstrate the efficacy of aromatic hydrazide compounds to inhibit growth of Mycobacterium tuberculosis. Study Design: To synthesize tuberculostats and test their antibacterial activity in-vitro. Place and Duration of Study: University of Nebraska, Durham Science Center, 6001 Dodge Street, Omaha NE 68182, and Texas A&M Health Science Center, Department of Microbial Pathogenesis and Immunology, 8447 State Hwy 47, Medical Research and Education Building, Room #3012, Bryan, TX 7780. From March 2019 to October 2019. Methodology: Hydrazide functional groups were formed by covalently bonding hydrazine onto a carbonyl carbon that is a substituent of a single aromatic ring. Microwave excitation was utilized for synthesis, followed by evaluation of antibacterial activity. These compounds were placed into tissue culture media at various concentrations and then Mycobacterium tuberculosis bacteria was added, in order to determine the level of growth inhibition. Growth inhibition of the bacteria was measured as a function of compound concentration versus growth inhibition. Results: Compounds A, B, C, and D carry hydrazide groups as a substituent to a single aromatic ring. All four compounds show zero violations of Rule of 5, indicating favorable drug-likeness. All four compounds showed greater than 50% growth inhibition of bacteria at concentrations below 50 micrograms per milliliter. Growth inhibition was measured by colony forming units and luminescence. Polar surface area, Log P, molecular volume, and other molecular properties were determined for these four compounds. Conclusion: These four hydrazide compounds induced substantial inhibition of bacterial growth. Microwave excitation for the synthesis of hydrazide compounds is effective. These compounds have favorable drug-likeness properties and are highly effective inhibiting the growth of Mycobacterium tuberculosis

Four Compounds Suppressing Growth of Mycobacterium tuberculosis

Aims: To demonstrate the efficacy of several small molecular weight compounds having hydrazide groups, for inhibiting the growth of Mycobacterium tuberculosis. To show these same compounds have favorable drug-likeness properties. Study Design: To synthesize tuberculostats and test their antibacterial activity in-vitro. Place and Duration of Study: University of Nebraska, Durham Science Center, 6001 Dodge Street, Omaha NE 68182, and Texas A&M Health Science Center, Department of Microbial Pathogenesis and Immunology, 8447 State Hwy 47, Medical Research and Education Building, Room #3012, Bryan, TX 7780. From January 2015 to June 2015. Methodology: Hydrazide groups were formed by covalently bonding hydrazine onto small molecules having a single aromatic ring by utilizing microwave excitation and evaluating for antibacterial activity. These compounds were placed into tissue culture media at various concentrations and then tuberculosis bacteria were added to determine the level of growth inhibition. Growth inhibition of the bacteria was measured as a function of compound concentration for assessment and comparison. Results: Compounds A, B, C, and D carry hydrazide groups with various substituents that are bonded to a single aromatic ring. All four compounds show zero violations of Rule of 5, indicating favorable absorption and membrane permeation. All four compounds showed greater than 85% growth inhibition of bacteria at concentrations below 50 micrograms per milliliter, while assayed by colony forming units and luminescence. Values of Log BB suggests compounds A and C will have greater penetration into the central nervous system than isoniazid. Conclusion: These four hydrazide compounds induced substantial inhibition of bacterial growth. Microwave excitation for the synthesis of hydrazide compounds is effective. These compounds have favorable drug-likeness properties and are highly effective inhibiting growth of Mycobacterium tuberculosis

Novel Tuberculostatic Agents Suitable for Treatment of Mycobacterium tuberculosis Infections of the Central Nervous System

Aims: To demonstrate the efficacy of five small molecule compounds for inhibiting the growth of Mycobacterium tuberculosis. To present evidence that these compounds will penetrate into the central nervous system. Study Design: Five small molecule compounds bearing a hydrazide group were synthesized utilizing microwave excitation. These compounds were then placed into tissue culture with Mycobacterium tuberculosis at various concentrations for evaluation of bacterial growth inhibition. Place and Duration of Study: The compounds to be tested were prepared at the University of Nebraska Chemistry Department August 2013. The evaluation of antibacterial activity was determined at the Texas A&M Health Science Center during October to December of 2013. Methodology: Applying microwave excitation for generation of hydrazide groups within the structure of small molecule carboxylic acids, five agents were prepared for evaluation of bacterial growth inhibition. These agents were dissolved into tissue culture media at various concentrations. Having various levels of tuberculostatic agents, then tuberculosis bacteria were added to determine level of growth inhibition. Growth inhibition of the bacteria was achieved and measured by compound concentration for comparison and evaluation. Results: Five compounds having a hydrazide functional group greatly inhibited the growth of Mycobacterium tuberculosis. All five agents had molecular weight less than 215 grams/mole and polar surface area of less than 70 Angstroms2. Values of Log P ranged from -0.226 to 0.998. Values of Log BB (Log [Cbrain/Cblood]) ranged from -0.711 to - 0.525, with a range in central nervous system penetration Cbrain/Cblood of 0.195 to 0.299. All compounds showed zero violations of the Rule of 5. Substantial inhibition of bacterial growth was observed at concentrations as low as 30 micrograms/mL, as measured by optical density and colony forming units. Conclusion: These five hydrazide compounds substantially decreased the proliferation of tuberculosis bacteria at concentrations as low as 30 micrograms/mL. In addition, their physicochemical properties are shown to allow high levels of penetration into the central nervous system