Fermi Coordinates and Penrose Limits

We propose a formulation of the Penrose plane wave limit in terms of null Fermi coordinates. This provides a physically intuitive (Fermi coordinates are direct measures of geodesic distance in space-time) and manifestly covariant description of the expansion around the plane wave metric in terms of components of the curvature tensor of the original metric, and generalises the covariant description of the lowest order Penrose limit metric itself, obtained in hep-th/0312029. We describe in some detail the construction of null Fermi coordinates and the corresponding expansion of the metric, and then study various aspects of the higher order corrections to the Penrose limit. In particular, we observe that in general the first-order corrected metric is such that it admits a light-cone gauge description in string theory. We also establish a formal analogue of the Weyl tensor peeling theorem for the Penrose limit expansion in any dimension, and we give a simple derivation of the leading (quadratic) corrections to the Penrose limit of AdS_5 x S^5.Comment: 25 page

Associations of a Panel of Adipokines with Fat Deposits and Metabolic Phenotypes in a General Population

Objective This study provides a comprehensive overview of the associations of five adipokines (adiponectin, chemerin, galectin‐3, leptin, and resistin) with fat deposits, behavioral risk factors, and metabolic phenotypes. Methods Using multivariable linear and logistic regression models, cross‐sectional data from 4,116 participants of the population‐based Study of Health in Pomerania were analyzed. Results Participants with obesity showed higher chemerin, galectin‐3, and leptin but showed lower adiponectin concentrations. Independently of other fat compounds, liver fat content, visceral adipose tissue, and subcutaneous adipose tissue (SAT) were inversely associated with adiponectin. Independent positive associations of liver fat content and SAT with chemerin as well as of SAT with galectin‐3 and leptin were observed. Physically inactive participants had higher chemerin and leptin concentrations. Smokers had higher chemerin and galectin‐3 as well as lower leptin. Alcohol consumption was associated with adiponectin (positive) and resistin (inverse). All adipokines were associated with at least one lipid marker. Associations with glucose metabolism were seen for adiponectin, chemerin, galectin‐3, and leptin. Conclusions High adiponectin concentrations were related to favorable metabolic conditions, whereas high chemerin, galectin‐3, and leptin were associated with an unfavorable metabolic profile. High leptin seems to be primarily indicative of obesity, whereas high adiponectin and chemerin are associated with a broader range of metabolic phenotypes

CYTOTOXICITY OF WATER EXTRACTS FROM LEAVES AND BRANCHES OF PHILADELPHUS CORONARIUS L.

Philadelphus coronarius L. is big, leggy and deciduous old-fashioned shrub known for its fragrant white flowers in the late spring. Some members of genus Philadelphus L. are known for their antibacterial, antiradical and immuno-modulatory effects. Therefore, these herbs represent prospective sources for the isolation of active substances with desired effects. We have investigated the cytotoxicity effects of water extracts from leaves and branches of Philadelphus coronarius L. (Hydrangeaceae). A431 cells (human skin carcinoma cell line) and the human breast adenocarcinoma cell line (MCF-7) were treated with various doses of individual extracts (0,1–100 μg dry matter/ml) for 24 h and 72 h. The highest toxic effects of both plant parts extracts were observed on MCF-7 cells regardless the time of treatment. Cells A431 were less sensitive to toxic effects of leaves and branches extracts but the time dependence was present with the tendency of increased toxicity after chronic treatment. There were no differences in the extent of toxic effects between branches and leaves extracts. The results obtained so far will provide the basis for the future studies with isolated ac-tive substances from these extracts