Gambaran Histopatologik Hati Tikus Wistar Yang Diberi Minuman Kopi Pasca Induksi Karbon Tetraklorida (CCl4)

: Liver is the central of body metabolism and therefore is the major organ that suffers the most when subjected to free radicals and toxins, e.g carbon tetrachloride (CCl4). One of the herbal plants that is useful for treating liver damage is coffee. Coffee beans contains chlorogenic acid, an antioxidant, that can prevent liver damage. This study aimed to obtain a histopathological features of the liver of Wistar rats administered with coffee after induced with CCl4. This was a laboratory experimental study. Samples were 24 Wistar rats (Rattus norvegicus) divided into four groups. Rats in group 1 were the negative control. Rats in group 2 were induced with CCl4 0.05 ml/day for 5 days. Rats in group 3 were induced with CCl4 0.05 ml/day for 5 days, followed by coffee administration 1 ml/day for 7 days. Rats in group 4 were induced with CCl4 0.05 ml/day for 5 days then were given no treatment for 7 days. Termination was done on day 6 (group 1 and 2) and day 13 (group 3 and 4). The results showed that rats in group 2 histophatologically showed fatty liver formation and inflammation. Rats in group 3 were the same as group 4 in the terms showed regeneration of hepatocytes. Conclusion: Administration of coffe 1 ml/day (single dose) for seven days after induction with CCl4 for five days showed regeneration of hepatocytes which was similar to that in physiological condition