Paving the Way Ahead: A Systematic Literature Analysis of Inclusive Teaching Practices in Inclusive Classrooms

Classroom deliberations in an inclusive environment is challenging yet rewarding. Teaching students with varied needs under the same roof provides the teachers with the opportunity to bring out their best and to help students to attain an optimum level of learning. The purpose set for this paper is to conduct a rigorous review of inclusive teaching-learning practices across countries to understand and present the best ways of conducting an inclusive classroom. To explore the stated objective the researchers opted for an extensive desk review method to review the available related literature in a systematic manner. As a result of conducting a systematic review analysis, certain themes have emerged under which plausible inclusive practices have been presented as a finding of the research. The study presented five categories of best teaching practices that emerged from the review. This paper presented a concise and accumulated version of the best practices and methods adopted by the practitioners in inclusive education across the world. Amalgamated findings present that using ICT, individualised learning and various classroom management techniques, collaboration and curriculum adaptations provide the best ways to promote inclusion

The Caenorhabditis elegans D2-like dopamine receptor DOP-2 physically interacts with GPA-14, a Gαi subunit

Dopaminergic inputs are sensed on the cell surface by the seven-transmembrane dopamine receptors that belong to a superfamily of G-protein-coupled receptors (GPCRs). Dopamine receptors are classified as D1-like or D2-like receptors based on their homology and pharmacological profiles. In addition to well established G-protein coupled mechanism of dopamine receptors in mammalian system they can also interact with other signaling pathways. In C. elegans four dopamine receptors (dop-1, dop-2, dop-3 and dop-4) have been reported and they have been implicated in a wide array of behavioral and physiological processes. We performed this study to assign the signaling pathway for DOP-2, a D2-like dopamine receptor using a split-ubiquitin based yeast two-hybrid screening of a C. elegans cDNA library with a novel dop-2 variant (DOP-2XL) as bait. Our yeast two-hybrid screening resulted in identification of gpa-14, as one of the positively interacting partners. gpa-14 is a Gα coding sequence and shows expression overlap with dop-2 in C. elegans ADE deirid neurons. In-vitro pull down assays demonstrated physical coupling between dopamine receptor DOP-2XL and GPA-14. Further, we sought to determine the DOP-2 region necessary for GPA-14 coupling. We generated truncated DOP-2XL constructs and performed pair-wise yeast two-hybrid assay with GPA-14 followed by in-vitro interaction studies and here we report that the third intracellular loop is the key domain responsible for DOP-2 and GPA-14 coupling. Our results show that the extra-long C. elegans D2-like receptor is coupled to gpa-14 that has no mammalian homolog but shows close similarity to inhibitory G-proteins. Supplementing earlier investigations, our results demonstrate the importance of an invertebrate D2-like receptor's third intracellular loop in its G-protein interaction

Histopathological evaluation of abnormal uterine bleeding with immunohistochemical study of significant estrogen receptor expression in endometrium of women with different age groups

Background: Abnormal uterine bleeding is symptom, not disease. Bleeding per vaginum is labelled to be pathological when there is constant irregularity in pattern and flow of bleeding, altered duration or increased amount of menstrual blood. Histopathological examination of endometrium biopsies remains a gold standard diagnostic tool. Methods: A prospective study was done on 150 patients presenting with AUB over the period January 2022 to December 2022 in the department of pathology, Hind institute of medical sciences, Sitapur, Uttar Pradesh, India. The sections were stained with hematoxylin and eosin and special stain estrogen receptor was used. Results: Majority of the patients were seen in the perimenopausal age group and most common complaint was menorrhagia in 73 patients (48%). The commonest pathology observed in our study was proliferative phase endometrium in 48 patients (32%). Most of the endometrial carcinoma (4%) were presented after the age of 50 years. The association between histopathological patterns and estrogen receptor category were found to be statistically significant as the p<0.05. Conclusions: Disease burden on a global scale is witnessed by women affected by AUB thus having a detrimental impact. Accurate diagnosis of AUB in women over the age of 35yrs is important to rule out preneoplastic lesions and malignancies so that surgical interventions can be avoided by initiating proper medical management. Comparing the hyperplastic and neoplastic endometrium to that of the proliferative phase, ER expression was lower. Endometrial carcinoma with advanced stage often lacks the expression of the receptors

Expression of Ki-67 in premalignant and malignant lesion of cervix in tertiary care hospital in Uttar Pradesh

Background: cancer is fast emerging as one of the most common causes of death related morbidities throughout the world. As far as India is concerned. Ki-67 is an ideal marker to assess the cellular proliferation. The study aimed to evaluate the proliferative activity by using Ki-67 in premalignant and malignant lesion of cervix. To study the various histomorphology features of cervical lesion and grading it into cervical intraepithelial neoplasia and malignant lesion. To access the expression of Ki 67 in different grade of lesions. Methods: The study was carried in 60 cases of cervical biopsy that included 30 cases of CIN 1, CIN2 and 30 cases of CIN 3, SCC. Ki-67 staining was done on all cases which were diagnosed histologically as CIN or cervical carcinoma. The result was categorized in grading 1,2,3. Results: Ki-67 expression was studied in all cases. There was an increase in the intensity of Ki-67 from CIN to carcinoma. The focal positivity in low grade lesion to diffuse positivity in higher grade lesion was seen in our study. Conclusions: In this study, Ki-67 expression was helpful in differentiating dysplastic lesion from carcinoma and helps in confirming the histopathological diagnosis. Therefore Ki-67 marker could be used as biomarker in the evaluation of the proliferative activity and progressive potential of dysplastic and neoplastic changes

DEVELOPMENT OF ADVANCED SMART AND SECURED SYSTEM

A smart system is designed to control the lighting system, fans and security in the industries. We all know sometimes forget to switch off the lights and fans before leaving the room. This system can control 8 units of lights and 6 units of fans every day. Besides, our highly developed industry consist of lot of appliances which needs security and care. Our project focuses on total security with the help of fire alarm and a message alert of any invader. This project uses the Passive Infrared Sensor (PIR sensor) to detect the body heat and the movements of humans. The PIR sensor will give signal to hardware. The hardware of this project is PIC16F887A and RS232 communication module to interface with GSM Modem

Planning oral health human resources for the province of KwaZulu-Natal

Please read the abstract in the section 00front of this documentDissertation (MSc (Community Dentistry))--University of Pretoria, 2006.Community Dentistryunrestricte

HEPATIC DYSFUNCTION IN DENGUE: A TERITARY CARE HOSPITAL EXPERINCE

Objective: The objective of the study was to evaluate liver dysfunction in patients with dengue infections and corelation between liver function test and platelet count. Methods: Hospital-based case−control study conducted on 141 hospitalized with Dengue infection (NS 1 and IgM positive). Dengue seropositive patients are selected and subjected to complete blood count and liver function tests were analyzed. Results: The participants were found to have elevated levels of SGOT, SGPT levels, and lower levels of serum albumin and platelet count as compare to control on evaluation. The significant negative correlation was noted between SGOT/SGPT levels and baseline platelet counts levels. The Pearson correlation between platelet count and SGOT showed r=−0.185 and p<0.01 which proves that when platelet count decreases, the SGOT levels increases. Similarly, for the correlation between platelet count and SGPT showed r=−0.166 and <0.01 which proves that when platelet count decreases, the SGPT levels increase. Conclusion: Statistically significant corelation was observed between liver enzymes with platelet count. Furthermore, the severity of dengue infection predicted the severity of liver derangements. It is recommended that patients with dengue infections be screened for hepatic dysfunction. As hepatic dysfunction in dengue is transient and reversible, early identification of the same would help to reduce life threatening complications

MENTAL HEALTH AND QUALITY OF LIFE DURING COVID-19 PANDEMIC IN INDIAN POPULATION

Objective: As there is a dearth of researches targeting the Indian population on this issue, we decided to conduct a survey to assess the psychological impact of COVID-19 on mental health and quality of life of Indians. Methods: In this Cross-Sectional study, a total of 2245 participants above 16 y of age were included. Mental health variables were assessed via depression, anxiety and stress subscale (DASS-21), Insomnia Severity Index (ISI-7), Patient health questionnaire (PHQ-15), Quality of life (QoL-5) and social media exposure. Results: The multivariate logistic regression demonstrated female (OR-1.17, 95% CI: 0.99 to 1.38) had significantly higher depression scores whereas, housewife had higher depression (OR-1.68, 95% CI: 1.33 to 2.13), anxiety (OR-1.64, 95% CI: 1.15 to 2.35), insomnia (OR-1.32, 95% CI: 1.14 to 1.53), somatic symptoms (OR-1.76, 95% CI: 1.21 to 2.57). Front line workers had a higher psychological impact with increased scores of anxieties (OR-1.23, 95% CI: 0.79 to 1.53), stress (OR-1.82, 95% CI: 0.76 to 2.55), insomnia (OR-1.65, 95% CI: 1.31 to 2.09). Lower education level had significantly higher score in depression (OR-1.14, 95% CI: 0.73 to 1.32), insomnia (OR-2.42, 95% CI: 2.07 to 2.84), somatic symptoms (OR-2.59, 95% CI: 1.80 to 3.37). Poor physical health, social media exposure was significantly associated with heightened anxiety score. Conclusion: There is a need for psychological intervention as the dynamics and severity of COVID-19 is rapidly changing. These findings could guide the public health authorities to target and implement health measures to combat the pandemic