Advanced Basestation Technology for Wireless Connectivity in Rural Areas

M.S

A study on tailor made ruthenium sulfoxide complexes: Synthesis, characterization and application

In this study, a dinucleating spacer incorporating two 2-aminopyridine units has been used to prepare seven novel dinuclear compounds. These molecules were characterized by elemental analyses, conductivity measurements, magnetic susceptibility, FT-IR, FAB-Mass, electronic, 1H and 13C{1H}NMR spectral studies. The complex [{trans,mer-RuCl2(DMSO)3}2(μ-5,5'-methylenebis(2-aminopyridine))].2DMSO, 2 was also characterized through 1H-1H COSY NMR. There are mainly three different formulations; [{cis,fac-RuCl2(SO)3}2(μ-MBAP)].2SO; [{trans,mer-RuCl2(SO)3}2(μ-MBAP)].2SO and [{trans-RuCl4(SO)}2(μ-MBAP)]2- [X]2+; where SO = DMSO / TMSO; MBAP = 5,5'-methylenebis(2-aminopyridine) and [X]+ = [(DMSO)2H]+, Na+ or [(TMSO)H]+. The coordination was found through cyclic nitrogen of pyridine ring in octahedral environment for both metal centers. The chemical behivour of [{cis,fac-RuCl2(DMSO)3}2(μ-5,5'-methylenebis(2-aminopyridine))].2DMSO, 1 and 2 in aqueous solution with respect to time was observed by conductivity measurements and UV-vis spectrophotometer. All complexes were found to possess prominent antibacterial activity against Escherichia coli in comparison to Chloramphenicol and Gatifloxacin

Metallo-antiviral aspirants: Answer to the upcoming virus outbreak

In light of the current SARS-CoV-2 outbreak, about one million research papers (articles, reviews, communications, etc.) were published in the last one and a half years. It was also noticed that in the past few years; infectious diseases, mainly those of viral origin, burdened the public health systems worldwide. The current wave of the Covid-19 pandemic has unmasked critical demand for compounds that can be swiftly mobilized for the treatment of re-emerging or emerging viral infections. With the potential chemical and structural characteristics of organic motifs, the coordination compounds might be a promising and flexible option for drug development. Their therapeutic consequence may be tuned by varying metal nature and its oxidation number, ligands characteristics, and stereochemistry of the species formed. The emerging successes of cisplatin in cancer chemotherapy inspire researchers to make new efforts for studying metallodrugs as antivirals. Metal-based compounds have immense therapeutic potential in terms of structural diversity and possible mechanisms of action; therefore, they might offer an excellent opportunity to achieve new antivirals. This review is an attempt to summarize the current status of antiviral therapies against SARS-CoV-2 from the available literature sources, discuss the specific challenges and solutions in the development of metal-based antivirals, and also talk about the possibility to accelerate discovery efforts in this direction

Experiences during Synthesis of a Dinucleating Spacer Incorporating 2-Chloropyridine Units Through Sandmayer Reaction

A bimetallic cuprous complex was accidentally reported, during synthesis of a dinucleating spacer incorporating two 2-chloropyridine units through Sandmayer reaction. The product was characterized by elemental analysis, FAB-Mass, FT-IR, UV, magnetic susceptibility and 1H-NMR spectroscopic method. A possible mechanism is also proposed

Microsoft Word - Research-Paper-2

Abstract: Syntheses of a small library of hydroxamates by reacting esters of different carboxylic acids with hydroxyl amine hydrochloride has been achieved. All the synthesized compounds were screened in vitro against Trypanosoma brucei brucei S427 and Plasmodium falciparum 3D7 strain. The IC 50 values of potent anti-trypanosomal agents ranged between 0.025-5.69 μg/mL, while these values varied in the range of 0.78 -40.89 μg/mL against P. falciparum. Five compounds with very good SI values were active against both the protozoans. Some compounds have also shown strong antifungal activities with MIC as low as 0.19 μg/mL. These simple low molecular weight hydroxamates with triple activities and high degree of SI values revealed a new strategy in malaria/HAT and fungal chemotherapy

Piscidin-1-analogs with double L- and D-lysine residues exhibited different conformations in lipopolysaccharide but comparable anti-endotoxin activities

To become clinically effective, antimicrobial peptides (AMPs) should be non-cytotoxic to host cells. Piscidins are a group of fish-derived AMPs with potent antimicrobial and antiendotoxin activities but limited by extreme cytotoxicity. We conjectured that introduction of cationic residue(s) at the interface of polar and non-polar faces of piscidins may control their insertion into hydrophobic mammalian cell membrane and thereby reducing cytotoxicity. We have designed several novel analogs of piscidin-1 by substituting threonine residue(s) with L and D-lysine residue(s). L/D-lysine-substituted analogs showed significantly reduced cytotoxicity but exhibited either higher or comparable antibacterial activity akin to piscidin-1. Piscidin-1-analogs demonstrated higher efficacy than piscidin-1 in inhibiting lipopolysaccharide (LPS)-induced pro-inflammatory responses in THP-1 cells. T15,21K-piscidin-1 (0.5 mg/Kg) and T15,21dK-piscidin-1 (1.0 mg/Kg) demonstrated 100% survival of LPS (12.0 mg/Kg)-administered mice. High resolution NMR studies revealed that both piscidin-1 and T15,21K-piscidin-1 adopted helical structures, with latter showing a shorter helix, higher amphipathicity and cationic residues placed at optimal distances to form ionic/hydrogen bond with lipid A of LPS. Remarkably, T15,21dK-piscidin-1 showed a helix-loop-helix structure in LPS and its interactions with LPS could be sustained by the distance of separation of side chains of R7 and D-Lys-15 which is close to the inter-phosphate distance of lipid A.MOE (Min. of Education, S’pore)Published versio