International Journal of Drug Regulatory Affairs

A REVIEW ON DRUG APPROVAL PROCESS FOR US, EUROPE AND INDIA Developing a new drug requires great amount of research work in chemistry, manufacturing, controls, preclinical science and clinical trials. Drug reviewers in regulatory agencies around the world bear the responsibility of evaluating whether the research data support the safety, effectiveness and quality control of a new drug product to serve the public health. Every country has its own regulatory authority, which is responsible to enforce the rules and regulations and issue the guidelines to regulate the marketing of the drugs. This article focuses on drug approval process in different countries like USA, Europe and India. This record was migrated from the OpenDepot repository service in June, 2017 before shutting down

Outcome of paediatric lateral condyle humerus fractures treated operatively

Background: Paediatric lateral humeral condyle fractures account for 17 % of the distal humeral fractures. Displaced and rotated fractures require appropriate reduction and stabilisation. Aims: The aim of the present study was to review the results of patients with a displaced lateral humeral condyle fracture treated with open reduction and internal fixation (ORIF). Material and methods: We prospectively reviewed 30 children operated for lateral humeral condyle fractures at a single institution over a period of 3 years. Age distribution, fracture classification, mode of fixation, time to union, complications and final outcomes at the latest follow-up were reviewed. Results: Total 30 patients of lateral condyle fractures were identified in which there were 18 male and 12 female patients. Average age was 8.07 years. 10 were Milch type II and 20 Milch type I. According to the Jacob’s classification, 05 were type I and 17 were type II and 08 were type III. All fractures were treated with open reduction and fixation with K-wires except one which was treated with CRIF. Average time to radiological union was 6.1 weeks. Radiological hypertrophy of the lateral condyle was present in 4 cases (13.33 %). 3 patients developed a pseudo-cubitus varus deformity. Conclusion: Our results demonstrate that fracture union and excellent final outcomes can be expected in all patients using our protocol, whereby all patients with a displaced fracture are managed by ORIF with K-wire fixation, with the wires only being removed after there is evidence of radiological union

Low-Light Shadow Imaging using Quantum-Noise Detection with a Camera

We experimentally demonstrate an imaging technique based on quantum noise modification after interaction with an opaque object. By using a homodyne-like detection scheme, we eliminate the detrimental effect of the camera's dark noise, making this approach particularly attractive for imaging scenarios that require weak illumination. Here, we reconstruct the image of an object illuminated with a squeezed vacuum using a total of 800 photons, utilizing less than one photon per frame on average

Multivariate analysis for study of genetic divergence in mungbean [Vigna radiata (L.) Wilczek] genotypes

Forty mungbean genotypes were evaluated for fourteen quantitative traits, planted in Randomized Complete Block Design with three replications. Mahalanobis' generalised distance D2 was used to assess the character data and Principal Component Analysis for estimating genetic diversity and identification of superior mungbean genotypes. Following Tocher's technique, the 40 genotypes were divided into 7 clusters in accordance with their genetic distance. Among them four clusters were polygenotypic and three were monogenotypic. The genotypes of cluster IV and VII showed highest (40.51) inter cluster distance followed by cluster III and VII (39.04). Cluster V has been discovered to have the largest intra-cluster distance. In order to increase the genetic diversity of Vigna radiata, genotypes from these clusters may be crossed. Based on Principal Component Analysis results, 5 PCs explained 75.87% of the variation among the 14 parameters and had eigen values greater than unit. Only six genotypes—TJM-37, TJM-134, TJM-140, TJM-235, Shikha, and PM-1632—contained with favourable yield and quality associated PCs, and had outstanding remark for yield traits—out of all genotypes contributing their existence in more than one PC with high PC score. These lines may be used in hybridization programmes to transmit desirable features, such as high yield and high quality, to recipient mungbean genotypes, resulting in the creation of promising cultivars

Ultralight vector dark matter search using data from the KAGRA O3GK run

Among the various candidates for dark matter (DM), ultralight vector DM can be probed by laser interferometric gravitational wave detectors through the measurement of oscillating length changes in the arm cavities. In this context, KAGRA has a unique feature due to differing compositions of its mirrors, enhancing the signal of vector DM in the length change in the auxiliary channels. Here we present the result of a search for U(1)B−L gauge boson DM using the KAGRA data from auxiliary length channels during the first joint observation run together with GEO600. By applying our search pipeline, which takes into account the stochastic nature of ultralight DM, upper bounds on the coupling strength between the U(1)B−L gauge boson and ordinary matter are obtained for a range of DM masses. While our constraints are less stringent than those derived from previous experiments, this study demonstrates the applicability of our method to the lower-mass vector DM search, which is made difficult in this measurement by the short observation time compared to the auto-correlation time scale of DM

Transportation of payload using quadcopters under physical constraint with human in the loop

by Pratik PrajapatiM.Tech

Centrally controlled on-chip criminal face recognition embedded in traffic cameras

This paper evaluates the ability of convolutional networks to solve the problems arising with face classification in a constrained environment. It has the design and implementation of Siamese architecture used for face verification using a single set of the photograph. Because of the intrinsic nature of the problem, computer vision is not only a computer science area of research, but also the object of neuroscientific and psychological studies, mainly because of the general opinion that advances in computer image processing and understanding research will provide insights into how our brain works and vice versa. In the scope of the paper, the training process is closely monitored and we evaluate several practices and parameters as well as their impact on network learning. This paper introduces some novel models for all steps of a face recognition system using embedded computers. In the step of single-shot face recognition, we propose a hybrid model combining Openface artificial neural network combined with siamese network architecture to solve the process efficiently. In the first step, faces detected by Google's mediapipe library will be aligned by Geometric corrections. In this alignment step, we propose a new 2D local texture model based on relative eyes inclination.&nbsp