Pengaruh Penambahan Sodium Lauril Sulfat (Sls) Sebagai Surfaktan Terhadap Sifat Fisik Dan Uji Disolusi Tablet Ketoprofen

Ketoprofen (acid 2-(3-benzoilfenil) propanoat) was derivated of propionat acid which has analgesic, antipyretic, and anti-inflammatory with poor solubillity in water. This research allowed to increase the dissolution rate of ketoprofen tablets and effect on the physical characteristic by adding sodium lauril sulfat as surfactant. Sodium lauryl sulfat is a surfactant that can be used to improve wetting and dissolution rate. This study was done with make four formula of ketoprofen tablets by different concentration of sodium lauryl sulfat (0%, 0,5%, 1%, and 1,5%) as a wetting agent. Ketoprofen without sodium lauryl sulfat was used as control. The tablets were made by wet granulation method. Tablet produced were tested for the physical characterisation (uniformity of weight, and hardness, friability, and disintegration time tablet) and dissolution test. The dissolution test were done by using pedal method with dissolution buffer of phosphate buffer pH 7,2 with spinning rate of 100 rpm in the temperature 37±0,5ºC for 60 minutes. The parameter used in this research is Dissolution Efficiency or DE30 (%). Data gained then analyzed statistically by using one way Analysis of Variance (ANOVA) and LSD (Least Significant Difference). The result showed the data have signifficant differences at the confidence of 95% The result of this study indicate that the addition of sodium lauryl sulfate had not effects on hardness, fragility and weight uniformity of tablets, but it has effect on the disintegration time. By adding more sodium lauryl sulfat, the disintegration time and the dissolution rate were greater. The percentage of ketoprofen dissolved after 30th minute, for formula I, II, III and IV respectively were 14,64% ; 29,66% ; 32,06% ; 35,81%. Key words: sodium lauryl sulfate, tablet, ketoprofen, dissolutio