Synthesis of novel benzo[4,5]imidazo[1,2-a]pyrimido- [4,5-d]pyrimidine derivatives as potent antimicrobial agents

445-453Synthesis of novel benzo[4,5]imidazo[1,2-a]pyrimido[4,5-d] pyrimidines 5/6 has been achieved by reaction of 2-amino-4-aryl-4,10-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine-3-carbonitriles 4 with formaldehyde/urea. The key intermediate 4, is obtained by reaction of 2-aminobenzaldehyde 1 with aromatic aldehyde and malononitrile by a three-component one-pot process. The newly synthesized title compounds 5/6 have been evaluated for their in vitro antimicrobial activity. Compounds 5 and 6 exhibit potent antimicrobial activity compared to that of standard drugs

Synthesis and antimicrobial activity of novel benzo[4', 5']-imidazo[1',2':1,2]pyrrolo[3,4-b]isoxazolo[4,5-e]pyridines

174-183Synthesis of novel benzo [4',5'] imidazo [1',2':1,2] pyrrolo [3,4-b] isoxazolo [4,5-e] pyridines 8 has been achieved by reaction of 1-(prop-2-yn-1-yl)-1H-benzo [d] imidazo-2-carbaldehydes 5 with 5-amino -3-methylisoxazole 6 in presence of InCl3 in CH3CN media, followed by reaction of imine 7 with BF3.Et2O in DCE at 80°C. The newly synthesized title compounds 8 have been evaluated for their in vitro antimicrobial activity. Compounds 8 exhibit potent antimicrobial activity compared to that of standard drugs

Japanese encephalitis virus associated post-infectious relapsing acute onset chronic demyelinating polyradiculoneuritis

Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an uncommon manifestation of Japanese encephalitis (JE) virus infection. JE is a neurotropic viral tropical disease affecting both CNS and PNS. Hereby report a case of acute onset CIDP (A-CIDP) following primary infection with JE who presented as symmetric flaccid areflexic sensorimotor quadriparesis with subsequent clinical improvement with steroids and plasmapheresis

Synthesis of novel benzo[4,5]imidazo[1,2-a]pyrimido- [4,5-d]pyrimidine derivatives as potent antimicrobial agents

Synthesis of novel benzo[4,5]imidazo[1,2-a]pyrimido[4,5-d] pyrimidines 5/6 has been achieved by reaction of 2-amino-4-aryl-4,10-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine-3-carbonitriles 4 with formaldehyde/urea. The key intermediate 4, is obtained by reaction of 2-aminobenzaldehyde 1 with aromatic aldehyde and malononitrile by a three-component one-pot process. The newly synthesized title compounds 5/6 have been evaluated for their in vitro antimicrobial activity. Compounds 5 and 6 exhibit potent antimicrobial activity compared to that of standard drugs

A simple and efficient one-pot synthesis of novel benzimidazo[1,2-a]- chromeno[4,3-d] pyrimidinones catalyzed by [Et3NH][HSO4]

1418-1424A simple and efficient one-pot synthesis of novel polyheterocyclic benzimidazo[1,2-a]- chromeno[4,3-d]pyrimidinones 4 via a three-component condensation of 2-aminobenzimidazole 1, aromatic aldehydes 2 and 4-hydroxy coumarin 3 catalyzed by Bronsted acid ionic liquid triethyl ammonium hydrogen sulphate [Et3NH][HSO4] under solvent-free conditions is reported. The main advantages of this protocol are short reaction time, easy work-up, operational simplicity, and excellent yields with high purity, without intervention of chromatography

Synthesis and antimicrobial activity of novel benzo[4', 5']-imidazo[1',2':1,2]pyrrolo[3,4-b]isoxazolo[4,5-e]pyridines

Synthesis of novel benzo [4',5'] imidazo [1',2':1,2] pyrrolo [3,4-b] isoxazolo [4,5-e] pyridines 8 has been achieved by reaction of 1-(prop-2-yn-1-yl)-1H-benzo [d] imidazo-2-carbaldehydes 5 with 5-amino -3-methylisoxazole 6 in presence of InCl3 in CH3CN media, followed by reaction of imine 7 with BF3.Et2O in DCE at 80°C. The newly synthesized title compounds 8 have been evaluated for their in vitro antimicrobial activity. Compounds 8 exhibit potent antimicrobial activity compared to that of standard drugs

Synthesis and antimicrobial activity of naphtho-[1,2-<em>e</em>][1,3]oxazines linked benzimidazole

1185-1192A new series of 2-(1H-benzo[d]imidazol-2-yl)-2,3-dihydro-1-aryl-1H-naphtho-[1,2-e][1,3]oxazines have been accomplished by a green protocol utilizing an efficient atom economic three component coupling reaction. The reaction of 2-amino benzimidazole, aromatic aldehydes with &beta;-naphthol on oil bath has produced the corresponding 1-(1H-benzo[d]imidazol-2-yl amino) phenyl (methyl) naphthalene-2-ols, which have been then cyclized to the title products by treatment with formaldehyde. The title compounds have been screened for their antimicrobial activity. Some of the compounds show promising antimicrobial activity