29 research outputs found
Synthesis of novel benzo[4,5]imidazo[1,2-a]pyrimido- [4,5-d]pyrimidine derivatives as potent antimicrobial agents
445-453Synthesis of novel benzo[4,5]imidazo[1,2-a]pyrimido[4,5-d] pyrimidines 5/6 has been achieved by reaction of 2-amino-4-aryl-4,10-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine-3-carbonitriles 4 with formaldehyde/urea. The key intermediate 4, is obtained by reaction of 2-aminobenzaldehyde 1 with aromatic aldehyde and malononitrile by a three-component one-pot process. The newly synthesized title compounds 5/6 have been evaluated for their in vitro antimicrobial activity. Compounds 5 and 6 exhibit potent antimicrobial activity compared to that of standard drugs
Japanese encephalitis virus associated post-infectious relapsing acute onset chronic demyelinating polyradiculoneuritis
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an uncommon manifestation of Japanese encephalitis (JE) virus infection. JE is a neurotropic viral tropical disease affecting both CNS and PNS. Hereby report a case of acute onset CIDP (A-CIDP) following primary infection with JE who presented as symmetric flaccid areflexic sensorimotor quadriparesis with subsequent clinical improvement with steroids and plasmapheresis
A simple and efficient one-pot synthesis of novel benzimidazo[1,2-a]- chromeno[4,3-d] pyrimidinones catalyzed by [Et3NH][HSO4]
A simple and efficient one-pot synthesis of novel polyheterocyclic benzimidazo[1,2-a]- chromeno[4,3-d]pyrimidinones 4 via a three-component condensation of 2-aminobenzimidazole 1, aromatic aldehydes 2 and 4-hydroxy coumarin 3 catalyzed by Bronsted acid ionic liquid triethyl ammonium hydrogen sulphate [Et3NH][HSO4] under solvent-free conditions is reported. The main advantages of this protocol are short reaction time, easy work-up, operational simplicity, and excellent yields with high purity, without intervention of chromatography
Synthesis and antimicrobial activity of novel benzo[4', 5']-imidazo[1',2':1,2]pyrrolo[3,4-b]isoxazolo[4,5-e]pyridines
174-183Synthesis of novel benzo [4',5'] imidazo [1',2':1,2] pyrrolo [3,4-b] isoxazolo [4,5-e] pyridines 8 has been achieved by reaction of 1-(prop-2-yn-1-yl)-1H-benzo [d] imidazo-2-carbaldehydes 5 with 5-amino -3-methylisoxazole 6 in presence of InCl3 in CH3CN media, followed by reaction of imine 7 with BF3.Et2O in DCE at 80°C. The newly synthesized title compounds 8 have been evaluated for their in vitro antimicrobial activity. Compounds 8 exhibit potent antimicrobial activity compared to that of standard drugs
Synthesis of novel benzo[4,5]imidazo[1,2-a]pyrimido- [4,5-d]pyrimidine derivatives as potent antimicrobial agents
Synthesis of novel benzo[4,5]imidazo[1,2-a]pyrimido[4,5-d] pyrimidines 5/6 has been achieved by reaction of 2-amino-4-aryl-4,10-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine-3-carbonitriles 4 with formaldehyde/urea. The key intermediate 4, is obtained by reaction of 2-aminobenzaldehyde 1 with aromatic aldehyde and malononitrile by a three-component one-pot process. The newly synthesized title compounds 5/6 have been evaluated for their in vitro antimicrobial activity. Compounds 5 and 6 exhibit potent antimicrobial activity compared to that of standard drugs
A simple and efficient one-pot synthesis of novel benzimidazo[1,2-a]- chromeno[4,3-d] pyrimidinones catalyzed by [Et3NH][HSO4]
1418-1424A simple and efficient one-pot synthesis of novel polyheterocyclic benzimidazo[1,2-a]- chromeno[4,3-d]pyrimidinones 4 via a three-component condensation of 2-aminobenzimidazole 1, aromatic aldehydes 2 and 4-hydroxy coumarin 3 catalyzed by Bronsted acid ionic liquid triethyl ammonium hydrogen sulphate [Et3NH][HSO4] under solvent-free conditions is reported. The main advantages of this protocol are short reaction time, easy work-up, operational simplicity, and excellent yields with high purity, without intervention of chromatography
Synthesis and antimicrobial activity of novel benzo[4', 5']-imidazo[1',2':1,2]pyrrolo[3,4-b]isoxazolo[4,5-e]pyridines
Synthesis of novel benzo [4',5'] imidazo [1',2':1,2] pyrrolo [3,4-b] isoxazolo [4,5-e] pyridines 8 has been achieved by reaction of 1-(prop-2-yn-1-yl)-1H-benzo [d] imidazo-2-carbaldehydes 5 with 5-amino -3-methylisoxazole 6 in presence of InCl3 in CH3CN media, followed by reaction of imine 7 with BF3.Et2O in DCE at 80°C. The newly synthesized title compounds 8 have been evaluated for their in vitro antimicrobial activity. Compounds 8 exhibit potent antimicrobial activity compared to that of standard drugs
Synthesis and antimicrobial activity of naphtho-[1,2-<em>e</em>][1,3]oxazines linked benzimidazole
1185-1192A new series of 2-(1H-benzo[d]imidazol-2-yl)-2,3-dihydro-1-aryl-1H-naphtho-[1,2-e][1,3]oxazines have been accomplished by a green protocol utilizing an efficient atom economic three component coupling reaction. The reaction of 2-amino benzimidazole, aromatic aldehydes with β-naphthol on oil bath has produced the corresponding 1-(1H-benzo[d]imidazol-2-yl amino) phenyl (methyl) naphthalene-2-ols, which have been then cyclized to the title products by treatment with formaldehyde. The title compounds have been screened for their antimicrobial activity. Some of the compounds show promising antimicrobial activity
Efficacy of Single-site versus Two-site Phacotrabeculectomy in Primary Open-angle Glaucoma: A Prospective Cohort Study
Introduction: The prevalence of co-existing cataract and
glaucoma is increasing in the adult population. Combined
surgeries have become more popular. However, there is a
conflict over which technique provides the best Intraocular
Pressure (IOP) control with good postoperative outcomes.
Aim: To compare the efficacy of single-site versus two-site
phacotrabeculectomy with mitomycin-C in patients with Primary
Open-angle Glaucoma (POAG) and cataract.
Materials and Methods: A prospective cohort study was
conducted in the Department of Ophthalmology, S.V. Medical
College, Tirupati, Andhra Pradesh, India, over a period of one year
from January 2019 to January 2020. A total of 50 cases of POAG coexisting with cataract were analysed in the present study. Twentyfive cases were included in each group (Group-1 and Group-2).
Phacoemulsification and trabeculectomy were both performed
through a superior scleral tunnel in the single-site approach.
The two-site method combines a superior trabeculectomy with
a temporal clear corneal phacoemulsification. A concentration of
0.2 mg/mL of MMC was applied in both groups for three minutes.
Patients were followed-up for three months after surgery to
evaluate Intraocular Pressure (IOP), the need for antiglaucoma
medication, and postoperative best-corrected Visual Acuity (VA).
Comparative analysis was done using the Student’s t-test, and a
p-value <0.05 was considered statistically significant.
Results: Throughout the three-month duration, the patients were
monitored. In the single-site group, the average preoperative
IOP was 21.880±8.4079 mmHg, which significantly decreased
to 11.16±9.95 mmHg after three months (p<0.001). In the twosite group, the corresponding figures were 22.640±6.3040 and
10.8±1.19 mmHg, respectively (p<0.001), with no discernible
statistical distinction between the two groups (p=0.486). At the
final follow-up, the number of antiglaucoma medications was
0.24±0.5 in the single-site group compared to 0.16±0.24 in the
two-site group. The mean postoperative Best Corrected Visual
Acuity (BCVA) did not exhibit any significant variation between
the two groups. Furthermore, there was no disparity in the
occurrence rate of complications between the two groups.
Conclusion: Both single and two-site phacotrabeculectomy led
to a significant reduction in IOP and improvement in BCVA. The
final IOP was similar in the two procedures, although the twosite group needed less glaucoma medication. As both surgical
procedures are equally effective, the choice of procedure
remains at the discretion of the surgeon