INVENTORY MANAGEMENT THROUGH EXTENDED STAR-RING SUPPLY CHAIN NETWORK

Objectives: The production-distribution inventory problem has two main sectors namely production and distribution. In this paper, the nonlinearmathematical model of extended star-ring supply chain network is developed.Methods: Planning a distribution network plays a vital role in minimizing the total expenditure of the project; to prove this, a ring network topology is taken to supply goods to the SWs and extended star network topology to supply goods to the selling stores. However, setting up separate SWs for each and every selling store will be highly expensive. Hence, keeping the minimum number of SWs is very important. Selection of SWs from the available SWs is done by replacing diverse values based on the distance limitation.Results: The suggested model is validated with the mathematical problem, and the optimum set of SWs is identified from the result. The result has been substantiated using analytic hierarchy process. Conclusion: The system of optimum number of SWs is obtained from the result.Â

Longitudinal top polarisation measurement and anomalous WtbWtb coupling

Kinematical distributions of decay products of the top quark carry information on the polarisation of the top as well as on any possible new physics in the decay of the top quark. We construct observables in the form of asymmetries in the kinematical distributions to probe their effects. Charged-lepton angular distributions in the decay are insensitive to anomalous couplings to leading order. Hence these can be a robust probe of top polarisation. However, these are difficult to measure in the case of highly boosted top quarks as compared to energy distributions of decay products. These are then sensitive, in general, to both top polarisation and top anomalous couplings. We compare various asymmetries for their sensitivities to the longitudinal polarisation of the top quark as well as to possible new physics in the $Wtb$ vertex, paying special attention to the case of highly boosted top quarks. We perform a $\chi ^2$- analysis to determine the regions in the longitudinal polarisation of the top quark and the couplings of the $Wtb$ vertex constrained by different combinations of the asymmetries. Moreover, we find that use of observables sensitive to the longitudinal top polarisation can add to the sensitivity to which the $Wtb$ vertex can be probed.Comment: significantly revised version, clarifications on the term 'polarisation' added, new references added, the title modified, 41 figures. Accepted for publication in EPJ

Non Endoscopic Predictors of Variceal Bleeding in Patients with Liver Cirrhosis

BACKGROUND: Esophageal varices develop as a consequence of portal hypertension in patients with chronic liver disease and are present in approximately 50% of patients with cirrhosis of the liver. Mortality rate of an episode of esophageal varical bleeding is approximately 20% at six weeks. Predicting the grade of varices by non-invasive methods at the time of registration is likely to predict the need for prophylactic β blockers or endoscopic variceal ligation in patients with cirrhosis and portal hypertension. Therefore, the present study has been undertaken to determine the appropriateness of the various clinical, biochemical and imaging parameters in predicting the existence and also the grade of esophageal varices in cirrhosis of the liver. METHODS: This was a prospective observational study which included 70 patients with liver cirrhosis who satisfied the inclusion and exclusion criteria.All patients included in the study were subjected to detailed history, clinical examination and blood investigations like liver function tests, complete blood counts including thrombocytopaenia, renal function tests, prothrombin time, Hepatitis B surface antigen, anti-HCV antibody. Ultrasonography of the abdomen and Ascitic fluid analysis including SAAG were done. And the patients were subjected to endoscopy. RESULTS: Of the seventy cases studied, presence of varices increases as patients progress to decompensated liver disease (Child Pugh grade B & C ). Decrease in platelet count below 100000/μL was found to be a predictor of esophageal varices in patients with cirrhosis. Increase in prothrombin time more than 25 seconds is associated with grade 2,3 varices. Value of serum ascitic albumin gradient (SAAG) more than 1.4g/dl is found to be a predictor for presence and large grade of esophageal varices .Portal vein diameter more than 1.3cm is associated with linear increase in grade of varices. Majority of patients with marked hepatic encephalopathy had grade 3 varices. In patients with serum albumin less than 3g/dl most of the patients had grade 3 varices. CONCLUSION: A combination of these non invasive parameters in cirrhotic patients like platelet count, portal vein diameter, SAAG, Prothrombin time along with serum albumin, encephalopathy grade, Child pugh score for screening esophageal varices can substantially reduce the cost of health care and discomfort for patients as well as reduce burden on endoscopy units

Predicting Clinical Outcome in Diabetics versus Nondiabetics with Acute Myocardial Infarction After Thrombolysis

Acute myocardial infarction can be considered as a potential epidemic for mankind (WHO 1982). Diabetes mellitus is one of the 6 primary risk factors identified for myocardial infarction. The aim of our study was to correlate the incidence of complications with diabetes by using ST segment resolution as a tool, thereby re-enforcing the role of incomplete ST resolution as a marker of worse clinical outcome in cases of diabetes with ST-elevated myocardial infarction in our populationST segment elevatio

Predicting Clinical Outcome in Diabetics versus Nondiabetics with Acute Myocardial Infarction After Thrombolysis

Acute myocardial infarction can be considered as a potential epidemic for mankind (WHO 1982). Diabetes mellitus is one of the 6 primary risk factors identified for myocardial infarction. The aim of our study was to correlate the incidence of complications with diabetes by using ST segment resolution as a tool, thereby re-enforcing the role of incomplete ST resolution as a marker of worse clinical outcome in cases of diabetes with ST-elevated myocardialinfarction in our population

Cutaneous metastases from primary carcinoma larynx - A rare presentation

The incidence of secondary cutaneous deposits from squamous cell carcinoma larynx is very rare. We report a sixty nine year old male who was diagnosed with squamous cell carcinoma of larynx who was treated with radiotherapy and chemotherapy, presented with multiple grouped nodules over the neck  in a zosterifom pattern. Eventhough nodular, plaque-like, exuberant growth and sclerodermoid skin metastases have been described in laryngeal carcinoma, metastases to the skin in a grouped pattern is uncommon with only one case reported so far in the literture. The possible hypothesised cause of dermatomal metastatic distribution my be secondary to perineural lymphatic invasion and invasion of dorsal root gangliaby malignant cells.

Urban Sprawl Mapping and Land Use Change Detection Analysis

Hasty changes occurred in the land use and land cover of Coimbatore city corporation, Tamil Nadu within 32 years span (1984 – 2016). Agricultural and forest lands are mainly converted into urban areas generally in an unplanned way which is making a change in dynamics of urban sprawl characteristics. The principal aim of this study is to use remote sensing data, geospatial tools to detect, quantify, analyze the urban land use changes of Coimbatore city, located in the western part of the Tamil Nadu. This study emphases on urban growth analyses and urban sprawl of Coimbatore city. In 2016, the jurisdiction of the Coimbatore Corporation was increased from 72 to 100 wards and five zones which consist area of 365.74Sq.Km. The corporation limit was extended from 29.25Sq.Km. in 1984 to 365.74 Sq. Km. in 2016 which has a growth of 1150 percent area of 1984. Various GIS layers such as Ward, Zone, Corporation boundaries, Road and railway network, Waterbody, Stream, Major locations and Land use / land cover including built-up area; agricultural land; water bodies; industrial area; educational area, and Public & Semi-public area were generated from Coimbatore Corporation map and Remote sensing imagery. This study revealed that Land use/Land cover areas such as agricultural, commercial, educational, industrial, public and semi-public, residential areas and water bodies occupied 9.38, 2.20, 5.0, 3.1, 1.02, 77.37 and 1.93 percentage areas of the city respectively in the year 2016. Land use pattern change was confirmed by field verification study in some places like near Gandhipuram, Brooke Fields, Avinashi Road, etc

Roman and inverse roman domination in network of triangles

In graph G (V, E), a function f : V → {0, 1 2} is said to be a Roman Dominating Function (RDF). If ∀u ∈ V, f(u) = 0 is adjacent to at least one vertex v ∈ V such that f(v) = 2. The weight of f is given by w(f) = P v∈V f(v). The Roman Domination Number (RDN) denoted by γR(G) is the minimum weight among all RDF in G. If V −D contains a RDF f 1 : V → {0, 1, 2}, where D is the set of vertices v, f(v) > 0, then f 1 is called Inverse Roman Dominating Function (IRDF) on a graph G with respect to the RDF f. The Inverse Roman Domination Number (IRDN) denoted by γ 1 R(G) is the minimum weight among all IRDF in G. In this paper we find RDN and IRDN of few triangulations graphs.Publisher's Versio

Regulation of Aurora Kinases and Their Activity

The three mitotic protein kinases Aurora-A, B and C are complementary enzymes that regulate multiple mitotic events. To do so, the different kinases must be locally activated, and the control of their activity is tightly regulated in time and space during mitosis. For instance, Aurora-A is first active at the centrosomes, then on microtubules at the spindle pole, Aurora-B is active in the nucleus, then at chromosome kinetochores and later one at the midbody. Aurora kinase activity is regulated in space and time by locally binding to regulators. Aurora kinases must bind to protein partners to be activated. Aurora-A for instance binds to targeting protein for Xenopus kinesin-like protein 2 (TPX2) and is activated at the spindle pole, Aurora-B and Aurora-C to INner CENtromer Protein (INCENP) and is activated on the chromosomes. These activations go through an autophosphorylation of a threonine residue in the T-loop of the kinase. Other protein partners are using different mechanisms to activate Auroras. These allow activation of the kinase at different time and location in the cell. This review is an up-to-date list of regulators of Aurora kinases. The subcellular localization of these regulators explains the presence of an active Aurora kinase. It also explains the changes in the localizations of the Aurora kinases activity observed during cell cycle progression in mitosis. Aurora kinases have been recently reported to be involved in nonmitotic events, and the identity of their activators in these events must be searched