FORMULATION AND OPTIMIZATION OF BUOYANT IN SITU GELLING SYSTEM OF VALSARTAN USING NATURAL POLYMER

Objective: Currently natural polymers have wide spread importance in fabrication of controlled drug delivery systems. Hence in this study ocimum basilicum mucilage, (OBM) a natural polymer used to know its effect as polymer alone and in combination with HPMC K15M and Guargum in oral in situ floating gel of Valsartan using 3 full level factorial design.Methods: FTIR studies conducted to know major drug polymer interactions. OBM, HPMC K15M and Guargum were chosen as three independent variables and examined at 3 levels for in vitro buoyancy (Y1) and drug release at 10 h (Y2) as responses. By using mathematical model approach formulation variables were quantitatively evaluated, and optimized formulation (VFIG) subjected for in vitro buoyancy, density, pH, in vitro drug release, drug content, gelling capacity and drug release kinetics. In addition VFIG studied for In vivo buoyancy and release kinetics.Results: FTIR studies revealed that excipients were compatible with drug. ANOVA results shown that independent variables have significant effect (p<0.05) on both the responses. Observed responses of optimized formulation (3 % OBM, 0.88 % HPMC and 1.25 % Guar gum) were in good agreement with the experimental values. Results of all in vitro evaluations lies within the limits and drug release kinetics followed non-fickian diffusion mechanism. In vivo buoyancy study in rabbit evidenced floatation for>8 h and in vivo pharmacokinetic study exhibited increased bioavailability of optimized formulation.Conclusion: Prepared VFIG with optimized concentrations of OBM, HPMC K15M and Guargum exploiting as a promising dosage form for enhanced gastric delivery

FORMULATION AND EVALUATION OF PRESS COATED TABLETS OF LANSOPRAZOLE

Objective: Lansoprazole an proton pump inhibitor, degrades in acidic environment, hence protection of drug is done by coating the drug with enteric coating polymers. The aim and objective of the present study was to prepare enteric coated delayed release tablets of lansoprazole by using press coating technique. Methods: Core tablets were prepared by direct compression and evaluated for their physico-chemical properties. Press coated tablets were formulated by using different combinations of ethyl cellulose, HPMC E15 and HPMC K4M as a coating layer. Core and coated tablets were optimized by dissolution studies. Fourier transform infra-red spectroscopy (FTIR) and differential scanning calorimetry (DSC) studies were performed to know the compatibility of drug with various excipients. Surface morphology and uniformity of coat was evaluated by Scanning electron microscopy (SEM). Stability of optimized formulation was evaluated according to ICH guidelines. Results: Among the various formulations F5 containing ethyl cellulose: HPMC E15 (10:90) and F9 containing ethyl cellulose: HPMC K4M (25:75) were optimized based on the better drug release within 8 h. DSC studies and FTIR studies revealed compatibility of drug with excipients. Obtained SEM photographs of tablets showed that the surface of core tablet is uniformly coated with coat by press coating. Stability studies showed that the formulations were stable. Conclusion: As a result, delayed release press coated tablets developed in this study delivered lansoprazole in the intestine and protected the drug from degradation

DEVELOPMENT AND VALIDATION OF RP- HPLC METHOD FOR METFORMIN HYDROCHLORIDE AND NATEGLINIDE IN BULK AND COMBINED DOSAGE FORM

Objective: To develop an accurate, precise and linear RP-HPLC method for simultaneous quantitative estimation of Metformin hydrochloride and Nateglinide in tablets and validate as per ICH guidelines.Methods: The method used a reverse phase column, Inertsil C18-ODS 3V (250×4.6 mm, 5 µm), a mobile phase comprising of phosphate buffer (pH 4.0): Acetonitrile: methanol (30:60:10) flow rate of 1.0 ml/min and a detection wavelength of 221 nm using a UV detector.Results: The developed method resulted in elution of Metformin hydrochloride at 2.45 min and Nateglinide at 4.21 min. The calibration curves were linear (r²=0.999) in the concentration range of 60-140 µg/ml and 14.4-33.2 µg/ml for Metformin hydrochloride and Nateglinide respectively. The percentage recoveries were found to be 99.59-101.36 for Metformin hydrochloride and 98.43-101.38 for Nateglinide. The LOD was found to be 2.18 µg/ml and 1.55 µg/ml for Metformin hydrochloride and Nateglinide respectively. LOQ was found to be 8.52µg/ml and 4.69µg/ml for Metformin hydrochloride and Nateglinide respectively.Conclusion: A simple, accurate, precise, linear and rapid RP-HPLC method was developed for simultaneous quantitative estimation of Metformin hydrochloride and Nateglinide in bulk and pharmaceutical formulation and validated as per ICH guidelines. Hence, the method holds good for the routine analysis of Metformin hydrochloride and Nateglinide in various pharmaceutical industries as well as in academics.Keywords: Metformin hydrochloride, Nateglinide, RP-HPLC, Method development, Validatio

Unscarred uterine rupture: a retrospective analysis

Uterine rupture is an obstetrical emergency associated with significant maternal and fetal mortality and morbidity. Spontaneous rupture of an unscarred uterus, though rare, can occur in developing countries. Many risk factors for uterine rupture, as well as a wide range of clinical presentations, have been identified. The aim of the study was to analyze the incidence, predisposing factors and to determine the maternal and perinatal outcomes of unscarred uterine rupture. A retrospective analysis of cases of unscarred uterine rupture was conducted at the department of obstetrics and gynecology, Andhra Medical College/King George Hospital, Visakhapatnam from 01 October 2020 to 31 October 2021. Out of the 8657 deliveries in our hospital during the study period, there were 11 cases of ruptured unscarred uteri giving an incidence of 0.127%. All of these (100%) were unbooked cases. Most of them (90.9%) were multigravida. Uterine rupture occurred at term in 9 cases and 2 were pre term. Maternal mortality was 18.18% (2 cases) and perinatal mortality was 72.72% (8 cases). Sub-total hysterectomy was done in 4 and laparotomy with repair of the rent was performed in the remaining 7 cases. Unscarred uterine rupture though a rare complication of pregnancy, can occur commonly in developing countries. Obstructed labour, mismanaged labour, injudicious use of oxytocin and grand multiparity are the common risk factors associated with unscarred uterine rupture

A REVIEW ON TRANSDERMAL DRUG DELIVERY SYSTEM: A NOVEL TOOL FOR IMPROVING BIOAVAILABILITY

Among all the dosages, oral is the best route of administration for its advantages but due to flow of its demerits like poor bioavailability due to first pass metabolism and unpredictable nature of gastrointestinal absorption. Moreover, oral route is cost prohibitive and inconvenient. Transdermal patches are medicated adhesive patches when it was placed on the skin layer it will deliver the drug into the blood stream through skin layer. To overcome the side effects caused by the oral route, drugs given through transdermal are preferred as transdermal patch. By employing sustained release polymers, transdermal patches can be prepared using solvent casting method. Drug excipients compatibility studies are very important to determine whether the excipients are suitable for that drug or not. These compatibility studies are very important to maintain the stability of dosage form. Evaluation studies are very important to determine the accuracy of dosage form at the same time therapeutic action also. Some of the parameters such as weight variation, physical appearance, drug content, moisture uptake, folding, endurance, swelling study and physical appearance, in vitro dissolution studies, ex vivo studies, and in vivo studies were evaluated

Delay Optimal Event Detection on Ad Hoc Wireless Sensor Networks

We consider a small extent sensor network for event detection, in which nodes take samples periodically and then contend over a {\em random access network} to transmit their measurement packets to the fusion center. We consider two procedures at the fusion center to process the measurements. The Bayesian setting is assumed; i.e., the fusion center has a prior distribution on the change time. In the first procedure, the decision algorithm at the fusion center is \emph{network-oblivious} and makes a decision only when a complete vector of measurements taken at a sampling instant is available. In the second procedure, the decision algorithm at the fusion center is \emph{network-aware} and processes measurements as they arrive, but in a time causal order. In this case, the decision statistic depends on the network delays as well, whereas in the network-oblivious case, the decision statistic does not depend on the network delays. This yields a Bayesian change detection problem with a tradeoff between the random network delay and the decision delay; a higher sampling rate reduces the decision delay but increases the random access delay. Under periodic sampling, in the network--oblivious case, the structure of the optimal stopping rule is the same as that without the network, and the optimal change detection delay decouples into the network delay and the optimal decision delay without the network. In the network--aware case, the optimal stopping problem is analysed as a partially observable Markov decision process, in which the states of the queues and delays in the network need to be maintained. A sufficient statistic for decision is found to be the network-state and the posterior probability of change having occurred given the measurements received and the state of the network. The optimal regimes are studied using simulation.Comment: To appear in ACM Transactions on Sensor Networks. A part of this work was presented in IEEE SECON 2006, and Allerton 201

POST NATAL DEPRESSION A CONCEALED MENACE AMONG SOUTH INDIAN WOMEN – A SYSTEMATIC OBSERVATIONAL ANALYSIS

Post-natal depression (PND) is a psychological interruption caused after childbirth. It is considered as a threat to women and the newborn that can even haul to fatality. The prevalence and its impact were surveyed in a rustic setup at Kodiyalam village (Tiruchirappalli district). It is aspired to assay the incidence of postnatal depression in a rustic system and detect the causes along with its deleterious outcomes. A survey method was adopted for the study by using purposive sampling technique. Data were collected by semi- structured interview schedule with 80 females as respondents. The survey reported that 16% of the women were affected by the symptoms of social withdrawal and lack of family intimacy. The poor socio economic status is the main reason for the onset of this discomfort and there is a need for intensive counseling and medications to attest this condition. Though there are numerous antidepressants to combat against this psychological condition the severity of its adverse effects are more than its symptoms. PND is an essential clinical condition that requires advanced research and therapeutic competence to strengthen the health of mother and child. This work suggests the implementation alternative strategy of smart herbal nanocomposites which can fortify the delivery of ayurvedic formulations encased with polymers under nanoscale. This can target therapeutics with a unique distribution that reduces its deleterious adverse effects

FABRICATION AND CHARACTERIZATION OF FAST DISSOLVING FILMS OF ECLIPTA PROSTRATE LEAVES EXTRACT TO TREAT MOUTH ULCERS

Objective: This research focused on the design of fast dissolving herbal film of Eclipta Prostrate leaves extract for mouth ulcers. Methods: The extract of Eclipta Prostrata leaves was formulated as films by solvent casting method using various polymers viz., HPMC E5, HPMC E15, sodium alginate and PVA. The films were designed by using propylene glycol as a plasticizer, SSG as super disintegrate and honey as a sweetener. Furthermore, the films were evaluated for thickness, folding endurance, weight variation, % elongation, surface pH, % moisture uptake, % moisture loss, disintegration and in vitro drug release study. Results: The revealed that all the films were good in appearance and had a smooth texture. Out of all ten formulations, F3 and F5 disintegrated rapidly with a disintegration time of 27 and 32 seconds. The drug release studies revealed that all the formulations had a good release profile, but the F3 formulation showed rapid release i.e. 83.57% in 4 min. The stability studies revealed that the formulations F3 and F5 were found good with non-tackiness, easily separable and disintegrated at 29 and 33 sec respectively with no appearance and drug release. Conclusion: The research revealed that Eclipta prostrate leaves extract can be formulated into oral films for the treatment of mouth ulcers with improved bioavailability and expected patient compliance

Assessment of Mechanical Property of Ti-5Ta-2Nb and 304L SS Explosive Clad and Correlation with Microstructure

AbstractSpent fuel reprocessing plants of FBRs require advanced structural materials for service in aggressive conditions. Ti-5Ta-2Nb is a candidate structural material for electrolytic dissolver whereas 304L SS is used for rest of the plant. ‘Zero failure’ requirement for the process vessels necessitated the development of defect free explosive clad between Ti-5Ta-2Nb and 304L SS. The paper deals with the investigations carried out on the mechanical properties and microstructure of the explosive clads, and modification in microstructure on subsequent thermal exposure. The structural integrity of the clad as a consequence of these structure-property changes is also discussed in the paper