10 research outputs found

    Nations within a nation: variations in epidemiological transition across the states of India, 1990–2016 in the Global Burden of Disease Study

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    18% of the world's population lives in India, and many states of India have populations similar to those of large countries. Action to effectively improve population health in India requires availability of reliable and comprehensive state-level estimates of disease burden and risk factors over time. Such comprehensive estimates have not been available so far for all major diseases and risk factors. Thus, we aimed to estimate the disease burden and risk factors in every state of India as part of the Global Burden of Disease (GBD) Study 2016

    IPA-Open access -Distributed under Creative Commons Attribution License 2.0 Management of Municipal Solid Waste by Vermicompost-A case study of Eluru

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    ABSTRACT Solid waste is an unwanted byproduct of modern civilization. Land fills are the most common means of solid waste disposal. But, the increasing amount of solid waste is rapidly filling existing land fills, and new sites are difficult to establish. Alternatives to land fills include the use of source reduction, recycling, composting and incineration, as well as use of land fills. Incineration is most economical if it includes energy recovery from the waste. Energy can be recovered directly from waste by incineration or the waste can be processed to produce storable refuse derived fuel (RDF). Information on the composition of solid wastes is important in evaluating alternative equipment needs, systems, management programs and plans. Household surveys are done in six divisions of Eluru Municipal Corporation, A.P, India and per-capita waste for the corporation is estimated. Pulverization of municipal solid waste is done and the pulverized solid waste is dressed to form a bed and the bed is fed by vermi's which converts the bed into vermi compost. The obtained vermi compost is sent to recognized lab for estimating the major nutrients i.e., Potassium (K), Phosphorous (P), Nitrogen (N) and Micro-nutrient values. It is estimated that 59 -65 tons of wet waste is generated in Eluru per day and if this wet waste is converted to quality compost 12.30 tons of vermi compost can be generated. If Municipal Corporation of Eluru(MCE) manages this wet waste an income of over rupees 0.89 crores per anum can be earned by MCE which is a considerable amount for providing of better services to public

    Mountain View Times

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    Weekly newspaper from Mountain View, Oklahoma that includes local, state, and national news along with advertising

    Fashioning readers: canon, criticism and pedagogy in the emergence of modern Oriya literature

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    Through a brief history of a widely published canon debate in nineteenth century Orissa, this article describes how anxieties about the quality of ‘traditional’ Oriya literature served as a site for imagining a cohesive Oriya public who would become the consumers and beneficiaries of a new, modernized Oriya-language canon. A public controversy about the status of Oriya literature was initiated in the 1890s with the publication of a serialized critique of the works of Upendra Bhanja, a very popular pre-colonial Oriya poet. The critic argued that Bhanja’s writing was not true poetry, that it did not speak to the contemporary era, and that it featured embarrassingly detailed discussions of obscene material. By unpacking the terms of this criticism and Oriya responses to it, I reveal how at the heart of these discussions were concerns about community building that presupposed a new kind of readership of literature in the Oriya language. Ultimately, this article offers a longer, regional history to the emerging concern of post-colonial scholarship with relationships between publication histories, readerships, and broader ideas of community – local, Indian, and global

    Ticagrelor in patients with diabetes and stable coronary artery disease with a history of previous percutaneous coronary intervention (THEMIS-PCI) : a phase 3, placebo-controlled, randomised trial

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    Background: Patients with stable coronary artery disease and diabetes with previous percutaneous coronary intervention (PCI), particularly those with previous stenting, are at high risk of ischaemic events. These patients are generally treated with aspirin. In this trial, we aimed to investigate if these patients would benefit from treatment with aspirin plus ticagrelor. Methods: The Effect of Ticagrelor on Health Outcomes in diabEtes Mellitus patients Intervention Study (THEMIS) was a phase 3 randomised, double-blinded, placebo-controlled trial, done in 1315 sites in 42 countries. Patients were eligible if 50 years or older, with type 2 diabetes, receiving anti-hyperglycaemic drugs for at least 6 months, with stable coronary artery disease, and one of three other mutually non-exclusive criteria: a history of previous PCI or of coronary artery bypass grafting, or documentation of angiographic stenosis of 50% or more in at least one coronary artery. Eligible patients were randomly assigned (1:1) to either ticagrelor or placebo, by use of an interactive voice-response or web-response system. The THEMIS-PCI trial comprised a prespecified subgroup of patients with previous PCI. The primary efficacy outcome was a composite of cardiovascular death, myocardial infarction, or stroke (measured in the intention-to-treat population). Findings: Between Feb 17, 2014, and May 24, 2016, 11 154 patients (58% of the overall THEMIS trial) with a history of previous PCI were enrolled in the THEMIS-PCI trial. Median follow-up was 3·3 years (IQR 2·8–3·8). In the previous PCI group, fewer patients receiving ticagrelor had a primary efficacy outcome event than in the placebo group (404 [7·3%] of 5558 vs 480 [8·6%] of 5596; HR 0·85 [95% CI 0·74–0·97], p=0·013). The same effect was not observed in patients without PCI (p=0·76, p interaction=0·16). The proportion of patients with cardiovascular death was similar in both treatment groups (174 [3·1%] with ticagrelor vs 183 (3·3%) with placebo; HR 0·96 [95% CI 0·78–1·18], p=0·68), as well as all-cause death (282 [5·1%] vs 323 [5·8%]; 0·88 [0·75–1·03], p=0·11). TIMI major bleeding occurred in 111 (2·0%) of 5536 patients receiving ticagrelor and 62 (1·1%) of 5564 patients receiving placebo (HR 2·03 [95% CI 1·48–2·76], p<0·0001), and fatal bleeding in 6 (0·1%) of 5536 patients with ticagrelor and 6 (0·1%) of 5564 with placebo (1·13 [0·36–3·50], p=0·83). Intracranial haemorrhage occurred in 33 (0·6%) and 31 (0·6%) patients (1·21 [0·74–1·97], p=0·45). Ticagrelor improved net clinical benefit: 519/5558 (9·3%) versus 617/5596 (11·0%), HR=0·85, 95% CI 0·75–0·95, p=0·005, in contrast to patients without PCI where it did not, p interaction=0·012. Benefit was present irrespective of time from most recent PCI. Interpretation: In patients with diabetes, stable coronary artery disease, and previous PCI, ticagrelor added to aspirin reduced cardiovascular death, myocardial infarction, and stroke, although with increased major bleeding. In that large, easily identified population, ticagrelor provided a favourable net clinical benefit (more than in patients without history of PCI). This effect shows that long-term therapy with ticagrelor in addition to aspirin should be considered in patients with diabetes and a history of PCI who have tolerated antiplatelet therapy, have high ischaemic risk, and low bleeding risk
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