Immnunomodulatory and cytotoxic effects of aqueous leaf extracts of certain plants on common carp, Cyprinus carpio

Effect of aqueous leaf extracts of Catheranthus roseus, Calotropis gigantium and Datura stromoneum on common carp, Cyprinus carpio were investigated. C. carpio were separately fed with 1 and 2% aqueous extracts of these three plant leaves for a period of seven days. In 1% Catheranthus roseus of leaf extract fed group no significant tissue level changes were recorded. One and 2% of other two species fed treated group showed mild to severe necrotic and cellular changes in liver, kidney and spleen. Immunologically, significant rise in antibody titre and respiratory burst activity was recorded for 1% Catheranthus roseusfed group

An efficient algorithm for discrete modelling of tracer kinetics

AbstractEffective study of certain health care problems and biomedical systems requires development and utilization of duly validated models for characterization of tracer kinetics in compartmental systems. This report presents an efficient algorithm for evaluation of discrete-time models in this context, starting from real patient data. The procedure evolved is systematic and involves parameter identification, model order determination and ascertaining the validity of the model: mathematical techniques proposed for this three-tier approach are robust as well as simple. A method for deriving state-space representations for multicompartmental systems directly from observations vector is also outlined. An illustrative example is given which demonstrates the effectiveness of the algorithm when applied to tracer analysis of the hepatobiliary system. The methodology proposed is recursive in nature such that it can be implemented very conveniently utilizing a microcomputer or even a programmable pocket calculator

Addition of NOCl to cyclic vinylsilanes: An unexpected reversal of regiochemistry

NOCl adds to cyclic vinylsilanes in a syn manner with NO+ bonding to the β-carbon and Cl- to the α-carbon, which is a reversal of the regiochemistry expected from the β-silicon effect. The adducts dimerize to a single diastereomer containing enantiomeric pairs and/or give secondary products on further reaction. © 2001 Elsevier Science Ltd

Not Available

Not AvailableNot AvailableNot Availabl

ChemInform Abstract: Addition of NOCl to Cyclic Vinylsilanes: An Unexpected Reversal of Regiochemistry.

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option

The systematic study of the influence of neutron excess on the fusion cross sections using different proximity-type potentials

Using different types of proximity potentials, we have examined the trend of variations of barrier characteristics (barrier height and its position) as well as fusion cross sections for 50 isotopic systems including various collisions of C, O, Mg, Si, S, Ca, Ar, Ti and Ni nuclei with $1\leq N/Z < 1.6$ condition for compound systems. The results of our studies reveal that the relationships between increase of barrier positions and decrease of barrier heights are both linear with increase of $N/Z$ ratio. Moreover, fusion cross sections also enhance linearly with increase of this ratio.Comment: 28 pages, 7 figures, 5 Table

Pleiotropic effects of the vacuolar ABC transporter MLT1 of Candida albicans on cell function and virulence.

Among the several mechanisms that contribute to MDR (multidrug resistance), the overexpression of drug-efflux pumps belonging to the ABC (ATP-binding cassette) superfamily is the most frequent cause of resistance to antifungal agents. The multidrug transporter proteins Cdr1p and Cdr2p of the ABCG subfamily are major players in the development of MDR in Candida albicans Because several genes coding for ABC proteins exist in the genome of C. albicans, but only Cdr1p and Cdr2p have established roles in MDR, it is implicit that the other members of the ABC family also have alternative physiological roles. The present study focuses on an ABC transporter of C. albicans, Mlt1p, which is localized in the vacuolar membrane and specifically transports PC (phosphatidylcholine) into the vacuolar lumen. Transcriptional profiling of the mlt1∆/∆ mutant revealed a down-regulation of the genes involved in endocytosis, oxidoreductase activity, virulence and hyphal development. High-throughput MS-based lipidome analysis revealed that the Mlt1p levels affect lipid homoeostasis and thus lead to a plethora of physiological perturbations. These include a delay in endocytosis, inefficient sequestering of reactive oxygen species (ROS), defects in hyphal development and attenuated virulence. The present study is an emerging example where new and unconventional roles of an ABC transporter are being identified

The model for self-dual chiral bosons as a Hodge theory

We consider (1+1) dimensional theory for a single self-dual chiral boson as classical model for gauge theory. Using Batalin-Fradkin-Vilkovisky (BFV) technique the nilpotent BRST and anti BRST symmetry transformations for this theory have been studied. In this model other forms of nilpotent symmetry transformations like co-BRST and anti co-BRST which leave the gauge-fixing part of the action invariant, are also explored. We show that the nilpotent charges for these symmetry transformations satisfy the algebra of de Rham cohomological operators in differential geometry. The Hodge decomposition theorem on compact manifold is also studied in the context of conserved charges.Comment: 19 pages, No figures, Revtex, Final version to appear in EPJ