Software reuse in a paralysis dataset based on categorical clustering and the Pearson distribution

AbstractSoftware reuse is the process of building software applications that make use of formerly developed software components. In this paper, we explain the benefits that can be obtained from using statistical procedures for prescribing medicines, especially in rural areas, which have limited resources available on hand. It should be noted that although the expert systems were successful in research, they never dominated the market when actual patient treatment was considered. The proposed methodology is compared with the categorical clustering technique. The Fenton and Melton Coupling Metric is considered for the evaluation of the statistic model. The reliability of this methodology is also considered

Software Reuse in Cardiology Related Medical Database Using K-Means Clustering Technique

Software technology based on reuse is identified as a process of designing software for the reuse purpose. The software reuse is a process in which the existing software is used to build new software. A metric is a quantitative indicator of an attribute of an item or thing. Reusability is the likelihood for a segment of source code that can be used again to add new functionalities with slight or no modification. A lot of research has been projected using reusability in reducing code, domain, requirements, design etc., but very little work is reported using software reuse in medical domain. An attempt is made to bridge the gap in this direction, using the concepts of clustering and classifying the data based on the distance measures. In this paper cardiologic database is considered for study. The developed model will be useful for Doctors or Paramedics to find out the patients level in the cardiologic disease, deduce the medicines required in seconds and propose them to the patient. In order to measure the reusability K means clustering algorithm is used.Comment: 5 pages. arXiv admin note: text overlap with arXiv:1212.031

Iodine nutrition and its assessment during pregnancy: a need for concern

Micro nutrient iodine was essential in biosynthesis of thyroid hormones (TH). These hormones play a vital role in the growth and development of human beings at various stages of life. TH are required for normal brain development at embryonic, fetal and at past natal stages. If deficiency of iodine occurs then thyroid hormone production was impaired, if deficiency of TH occurs it can cause irreversible damage of brain which leads to various disorders like metal retarded ness, cretinism and goiter known as iodine deficiency disorders (IDD). When compared to normal adults, pregnant women and school children 5-12 years age are more vulnerable IDD. Due to the physiological variations during pregnancy iodine requirements rose significantly from 150 µg/day in non-pregnant adult women to 250 μg/day. However recent iodine nutrition studies showed adequate iodine status but few countries like Sweden and South Africa showed iodine deficiency. This review gives an over view on iodine nutrition on global front

The Intelligent Agent-Based Knowledge Management System for Supporting Multimedia Systems Design on The Web

The diffusion of the Internet (and comparable communication infrastructures) has led to the emergence of a virtual global marketspace in which products and services are sold electronically. As a result, traditional intermediaries, such as travel agents or retailers, are being bypassed. This development effects not only products and services which can be digitized but also the marketing and distribution of physical products. We have scrutinized the interdependencies of product characteristics and traditional distribution structure, electronic commerce andthe emergence of new services and distribution structures trends in the automotive industry. The auto manufacturers are facing difficult choices on several fronts at a time: cybermediaries, independent (mega-)dealers and their own direct sales operations on the Web are competing with their exclusive dealers. Based on this analysis which reveals patterns of exacerbated competition, we will discuss strategic options for a business network redesig

Comparisons of ensiled maize, sorghum and pearl millet forages fed to sheep

Water-use efficient sorghum (7) and pearl millet (5) forages were compared with reference maize forage as silage tested with Nellore Brown sheep. Mean silage organic matter intake was 352, 297 and 137g!d in maize, sorghum and pearl millet silage, respectively Current pearl millet forage cultivars do not match maize forage in terms of fodder quality Of the 7 sorghum cultivars several were on par with maize though the cultivar dependent variation in intake was huge (254 to 343g!d). Anti-nutritive factors associated with sorghum like dhurrin were undetectable in the silages, although present in the fresh forage. A routine laboratory trait does not seem to describe sorghum and pearl millet forages adequately More research is required to understand the true nutritional potential of sorghum and in particular pearl millet forages. Dissemination of these forages based on only biomass yield should be discouraged

HIV Protein Sequence Hotspots for Crosstalk with Host Hub Proteins

HIV proteins target host hub proteins for transient binding interactions. The presence of viral proteins in the infected cell results in out-competition of host proteins in their interaction with hub proteins, drastically affecting cell physiology. Functional genomics and interactome datasets can be used to quantify the sequence hotspots on the HIV proteome mediating interactions with host hub proteins. In this study, we used the HIV and human interactome databases to identify HIV targeted host hub proteins and their host binding partners (H2). We developed a high throughput computational procedure utilizing motif discovery algorithms on sets of protein sequences, including sequences of HIV and H2 proteins. We identified as HIV sequence hotspots those linear motifs that are highly conserved on HIV sequences and at the same time have a statistically enriched presence on the sequences of H2 proteins. The HIV protein motifs discovered in this study are expressed by subsets of H2 host proteins potentially outcompeted by HIV proteins. A large subset of these motifs is involved in cleavage, nuclear localization, phosphorylation, and transcription factor binding events. Many such motifs are clustered on an HIV sequence in the form of hotspots. The sequential positions of these hotspots are consistent with the curated literature on phenotype altering residue mutations, as well as with existing binding site data. The hotspot map produced in this study is the first global portrayal of HIV motifs involved in altering the host protein network at highly connected hub nodes

Sodium-coupled Monocarboxylate Transporters in Normal Tissues and in Cancer

SLC5A8 and SLC5A12 are sodium-coupled monocarboxylate transporters (SMCTs), the former being a high-affinity type and the latter a low-affinity type. Both transport a variety of monocarboxylates in a Na+-coupled manner. They are expressed in the gastrointestinal tract, kidney, thyroid, brain, and retina. SLC5A8 is localized to the apical membrane of epithelial cells lining the intestinal tract and proximal tubule. In the brain and retina, its expression is restricted to neurons and the retinal pigment epithelium. The physiologic functions of SLC5A8 include absorption of short-chain fatty acids in the colon and small intestine, reabsorption of lactate and pyruvate in the kidney, and cellular uptake of lactate and ketone bodies in neurons. It also transports the B-complex vitamin nicotinate. SLC5A12 is also localized to the apical membrane of epithelial cells lining the intestinal tract and proximal tubule. In the brain and retina, its expression is restricted to astrocytes and Müller cells. SLC5A8 also functions as a tumor suppressor; its expression is silenced in tumors of colon, thyroid, stomach, kidney, and brain. The tumor-suppressive function is related to its ability to mediate concentrative uptake of butyrate, propionate, and pyruvate, all of which are inhibitors of histone deacetylases. SLC5A8 can also transport a variety of pharmacologically relevant monocarboxylates, including salicylates, benzoate, and γ-hydroxybutyrate. Non-steroidal anti-inflammatory drugs such as ibuprofen, ketoprofen, and fenoprofen, also interact with SLC5A8. These drugs are not transportable substrates for SLC5A8, but instead function as blockers of the transporter. Relatively less is known on the role of SLC5A12 in drug transport