No-Sense: Sense with Dormant Sensors

Wireless sensor networks (WSNs) have enabled continuous monitoring of an area of interest (body, room, region, etc.) while eliminating expensive wired infrastructure. Typically in such applications, wireless sensor nodes report the sensed values to a sink node, where the information is required for the end-user. WSNs also provide the flexibility to the end-user for choosing several parameters for the monitoring application. For example, placement of sensors, frequency of sensing and transmission of those sensed data. Over the years, the advancement in embedded technology has led to increased processing power and memory capacity of these battery powered devices. However, batteries can only supply limited energy, thus limiting the lifetime of the network. In order to prolong the lifetime of the deployment, various efforts have been made to improve the battery technologies and also reduce the energy consumption of the sensor node at various layers in the networking stack. Of all the operations in the network stack, wireless data transmission and reception have found to consume most of the energy. Hence many proposals found in the literature target reducing them through intelligent schemes like power control, reducing retransmissions, etc. In this article we propose a new framework called Virtual Sensing Framework (VSF), which aims to sufficiently satisfy application requirements while conserving energy at the sensor nodes.Comment: Accepted for publication in IEEE Twentieth National Conference on Communications (NCC-2014

HIV-1 reverse transcriptase mutations that confer decreased in vitro susceptibility to anti-RT DNA aptamer RT1t49 confer cross resistance to other anti-RT aptamers but not to standard RT inhibitors

RNA and DNA aptamers specific for HIV-1 reverse transcriptase (RT) can inhibit reverse transcription in vitro. RNA aptamers have been shown to potently block HIV-1 replication in culture. We previously reported mutants of HIV-1 RT with substitutions N255D or N265D that display resistance to the DNA aptamer RT1t49. Variant viruses bearing these mutations singly or in combination were compromised for replication. In order to address the wider applicability of such aptamers, HIV-1 RT variants containing the N255D, N265D or both (Dbl) were tested for the extent of their cross-resistance to other DNA/RNA aptamers as well as to other RT inhibitors. Both N265D and Dbl RTs were resistant to most aptamers tested. N255D mutant displayed mild resistance to two of the DNA aptamers, little change in sensitivity to three and hypersensitivity to one. Although all mutants displayed wild type-like ribonuclease H activity, their activity was compromised under conditions that prevent re-binding. This suggests that the processivity defect caused by these mutations can also affect RNase H function thus contributing further to the replication defect in mutant viruses. These results indicate that mutants conferring resistance to anti-RT aptamers significantly affect many HIV-1 RT enzymatic activities, which could contribute to preventing the development of resistance in vivo. If such mutations were to arise in vivo, our results suggest that variant viruses should remain susceptible to many existing anti-RT inhibitors. This result was tempered by the observation that NRTI-resistance mutations such as K65R can confer resistance to some anti-RT aptamers

Weakly commensurable arithmetic groups, lengths of closed geodesics and isospectral locally symmetric spaces

We introduce the notion of weak commensurabilty of arithmetic subgroups and relate it to the length equivalence and isospectrality of locally symmetric spaces. We prove many strong consequences of weak commensurabilty and derive from these many interesting results about isolength and isospectral locally symmetric spaces.Comment: 62 page

Systemic Therapy in Endometrial Cancer: Recent Advances.

Endometrial cancer is a chemosensitive disease. Studies have established a clear benefit of chemotherapy in advanced stages and trials are ongoing to define its role in early stages as well. As more molecular pathways are being elucidated there is increasing role for targeted agents and future looks quite promising. We did an extensive search both online and offline for all the relevant articles including chemotherapy and targeted therapy for endometrial cancer