1 research outputs found
Mechanochemical Synthesis of Olanzapine Salts and Their Hydration Stability Study Using Powder X‑ray Diffraction
A series
of olanzapine (OLN) dicarboxylic acid salts including
earlier reports on olanzapinium malonate (1:1) and maleate (1:1 and
1:2) were prepared mechanochemically using liquid assisted grinding
(LAG) in order to study their hydration stability. Powder X-ray diffraction
was used as a characterization tool during the investigation. On the
basis of the single crystal structures of respective OLN salts, a
negative correlation between the dicarboxylic acid chain length and
the hydration stability of the corresponding OLN salt was found. Our
observations suggest that the overall crystal packing, beyond the
stronger hydrogen bond synthon (N<sup>+</sup>–H···O<sup>–</sup> in OLN salts compared to O–H···N
in OLN hydrates) plays an important role in designing OLN salts with
better hydration stability. In addition, melting point analysis showed
that OLN dicarboxylic acid salts follow melting point alteration behavior
similar to the pure diacids