Hazard ratios and 95% confidence intervals for risk of death according to BMI category (40.0–59.9 versus 18.5–24.9 kg/m²) or continuous values of BMI between 40.0 and 59.9 kg/m² (per 5 kg/m²): subgroup analyses.

<p>*Calculated by including a cross-product term between the subgroup variable and BMI (40.0–59.9 versus 18.5–24.9 kg/m²); subgroup analyses for attained age and calendar year were stratified by follow-up period.</p>a<p>Models use attained age as the underlying time metric, and are adjusted for sex, race/ethnicity (white [all participants in the Swedish and Australian cohorts were coded as white], black, Asian/Pacific Islander, Hispanic, other/unknown), education (high school or less, post–high school, college, unknown), alcohol intake (grams of ethanol per day: 0, >0 to <10, ≥10, unknown), physical activity level (cohort-specific tertiles corresponding to low, medium, and high), and study.</p>b<p>Models excluded participants who entered the study at or after age 65 y; follow-up time was censored at age at study exit (due to loss to follow-up, death, or administrative end date) or age 65 y, whichever came first.</p>c<p>Models excluded participants who exited the study at or before age 65 y; follow-up began at age 65 y for those who entered the study before age 65 y.</p>d<p>Models excluded participants who entered the study on or after the year 2000; follow-up time was censored at study exit (due to loss to follow-up, death, or administrative end date) or the year 2000, whichever came first.</p>e<p>Models excluded participants who exited the study on or before the year 2000; follow-up began in the year 2000 for those who entered the study before the year 2000.</p

Description of participants with BMI in the normal-weight (18.5–24.9 kg/m²) and class III obesity (40.0–59.0 kg/m²) range, by cohort.

<p>Description of participants with BMI in the normal-weight (18.5–24.9 kg/m²) and class III obesity (40.0–59.0 kg/m²) range, by cohort.</p

Age-adjusted cause-specific mortality rates (number of deaths per 100,000 persons per year) by BMI category.

<p>Mortality rates were age-standardized using the age distribution of adults aged 20–84 y in the 2000 US census population; not shown if calculations based on fewer than five deaths in the BMI 40.0–59.9 kg/m² group.</p><p>*<i>p</i><0.05;</p><p>** <i>p</i><0.001.</p><p>ICD-10, International Classification of Diseases, tenth revision; n/a, not applicable.</p

Hazard ratios and 95% confidence intervals for risk of death by BMI category.

a<p>Models use attained age as the underlying time metric and were adjusted for sex and study.</p>b<p>Models use attained age as the underlying time metric, and are adjusted for sex, race/ethnicity (white [all participants in the Swedish and Australian cohorts were coded as white], black, Asian/Pacific Islander, Hispanic, other/unknown), education (high school or less, post–high school, college, unknown), alcohol intake (grams of ethanol per day: 0, >0 to <10, ≥10, unknown), physical activity level (cohort-specific tertiles corresponding to low, medium, and high), and study.</p>c<p>Using BMI = 40.0–44.9 kg/m² as the reference group.</p