Polymeric biomaterials for the delivery of platinum-based anticancer drugs

Since cisplatin, cis-diamminedichloroplatinum(II), received FDA approval for use in cancer treatment in 1978, platinum-based drugs have been one of the most widely used drugs for the treatment of tumors in testicles, ovaries, head and neck. However, there are concerns associated with the use of platinum-based anticancer drugs, owing to severe side effects and drug resistance. In order to overcome these limitations, various drug-delivery systems have been developed based on diverse organic and inorganic materials. In particular, the versatility of polymeric materials facilitates the tuning of drug-delivery systems to meet their primary goals. This review focuses on the progress made over the last five years in the application of polymeric nanoparticles for the delivery of platinum-based anticancer drugs. The present article not only describes the fundamental principles underlying the implementation of polymeric nanomaterials in platinum-based drug delivery, but also summarizes concepts and strategies employed in the development of drug-delivery systems.open112519Ysciescopu

Biomimetic synthesis of hybrid nanocomposite scaffolds by freeze-thawing and freeze-drying

The aim of this study is to biomimetically synthesize hydroxyapatite - hydrophilic polymer scaffolds for biomedical applications. This organic-inorganic hybrid has been structurally characterized and reveals a good microstructural control as seen by the SEM analysis and the nanosize of the particulates is confirmed by AFM microscopy. The characterization of such nano-structured composites would allow researchers to design new systems, tailoring properties for different applications. © Indian Academy of Sciences

INTEGRATED NUTRIENT MANAGEMENT IN POTATO WITH COMPOST MADE THROUGH DIFFERENT BIO-DEGRADATION PROCESSES

To achieve the goal of safe and sustainable food, the only realistic option now-a-days lies with the introduction of a low input farming system concept i.e. organic and integrated agriculture. Keeping in view the present scenario, a study was undertaken in Satyapole village, Haringhata block of Nadia district, West Bengal on integrated nutrient management in potatoes during rabi 2018 and 2019. The efficacy of different composts, in terms of their quality, easiness of preparation along with yield and economic attributes were accessed for the high nutrient loving crop, potato. The experiment was planned out in randomized block design (RBD) with 5 treatments and 4 replications. High yield with a marginal difference was found among all the treatments with integrated management. But, the treatment with 50% of recommended inorganic fertilizer dose (recommended dose N:P: K @ 200:150:150 kg/ha, 1/3 N, full P and 1/3 K as basal; 1st and 2nd top dressing with 1/3 N and 1/3 K) and vermicompost @ 5 ton/ha showed the best result. According to the B: C ratio composting with NOVCOM showed the best result whereas, in terms of the bio-degradation process with respect to its end-product quality, easiness of procedure, and cost, compost made through waste decomposer and NOVCOM has better results in comparison with vermicompost