Modified Electromagnetic Actuator for Active Suspension System

Active suspension is a type of suspension systems which can vary its damping value in order to adjust the spring firmness in accordance with the road conditions. Real Active Suspension incorporates an external actuator which helps in raising or lowering of vehicle chassis independently at each wheel. Generally, the actuators that are used for active suspension are Hydropneumatic, Electro-hydraulic or Electromagnetic actuators. A new concept of two-way electromagnetic actuation with the help of magnetic damping is proposed in this paper, which can extend its arm on both sides to facilitate active suspension mechanism in both humps and potholes. This increases the ride quality while maneuvering not only in humps, but also in dumps. It also describes about the comparison of spring materials, sophisticated design, construction and working principle of newly proposed actuator. Catia V5 software has been used to design and simulate the actuator model, different spring materials are analyzed and their shear stress and deflections are compared

Learning Individual Speaking Styles for Accurate Lip to Speech Synthesis

Humans involuntarily tend to infer parts of the conversation from lip movements when the speech is absent or corrupted by external noise. In this work, we explore the task of lip to speech synthesis, i.e., learning to generate natural speech given only the lip movements of a speaker. Acknowledging the importance of contextual and speaker-specific cues for accurate lip-reading, we take a different path from existing works. We focus on learning accurate lip sequences to speech mappings for individual speakers in unconstrained, large vocabulary settings. To this end, we collect and release a large-scale benchmark dataset, the first of its kind, specifically to train and evaluate the single-speaker lip to speech task in natural settings. We propose a novel approach with key design choices to achieve accurate, natural lip to speech synthesis in such unconstrained scenarios for the first time. Extensive evaluation using quantitative, qualitative metrics and human evaluation shows that our method is four times more intelligible than previous works in this space. Please check out our demo video for a quick overview of the paper, method, and qualitative results. https://www.youtube.com/watch?v=HziA-jmlk_4&feature=youtu.beComment: 10 pages (including references), 5 figures, Accepted in CVPR, 202

Characterization of Multiphase Polypyrrole/Vanadium Oxide Nano Composites for a.c. Conductivity and Dielectric Properties

Vanadium oxide: Phase-1 and Phase-2 nano powers were synthesized from vanadium pentoxide in the presence of glucose using hydrothermal technique. The polypyrrole/vanadium oxide (PV P-1 and PV P-2) nano composites were synthesized with 15, 30, 45 and 60 weight percents of vanadium oxide: Phase-1 and Phase-2 in pyrrole, by the chemical polymerization (oxidation) method. The SEM micrographs of vanadium oxide: Phase-1 and Phase-2 nano powders have shown  mixture of nano belts & rods and PV P-1 & PV P-2 nano composites indicate that the composites have cluster formation with almost spherical nature particles and form elongated chains at some places. Conductivity versus frequency  plots shown that exponential increase for conductivity. The value of s increases to 1.13x10-3 S/cm for 15 wt. % of VO2 P-1 in polypyrrole & to 2.43x10-3 S/cm for 30 wt. % of VO2 P-2 in polypyrrole at 1 MHz

Silk and its composites for humidity and gas sensing applications

Silk fibroin (SF) is a natural protein largely used in the textile industry with applications in bio-medicine, catalysis as well as in sensing materials. SF is a fiber material which is bio-compatible, biodegradable, and possesses high tensile strength. The incorporation of nanosized particles into SF allows the development of a variety of composites with tailored properties and functions. Silk and its composites are being explored for a wide range of sensing applications like strain, proximity, humidity, glucose, pH and hazardous/toxic gases. Most studies aim at improving the mechanical strength of SF by preparing hybrids with metal-based nanoparticles, polymers and 2D materials. Studies have been conducted by introducing semiconducting metal oxides into SF to tailor its properties like conductivity for use as a gas sensing material, where SF acts as a conductive path as well as a substrate for the incorporated nanoparticles. We have reviewed gas and humidity sensing properties of silk, silk with 0D (i.e., metal oxide), 2D (e.g., graphene, MXenes) composites. The nanostructured metal oxides are generally used in sensing applications, which use its semiconducting properties to show variation in the measured properties (e.g., resistivity, impedance) due to analyte gas adsorption on its surface. For example, vanadium oxides (i.e., V2O5) have been shown as candidates for sensing nitrogen containing gases and doped vanadium oxides for sensing CO gas. In this review article we provide latest and important results in the gas and humidity sensing of SF and its composites

NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells

Glucocorticoids are universally used in the treatment of acute lymphoblastic leukemia (ALL), and resistance to glucocorticoids in leukemia cells confers poor prognosis. To elucidate mechanisms of glucocorticoid resistance, we determined the prednisolone sensitivity of primary leukemia cells from 444 patients newly diagnosed with ALL and found significantly higher expression of CASP1 (encoding caspase 1) and its activator NLRP3 in glucocorticoid-resistant leukemia cells, resulting from significantly lower somatic methylation of the CASP1 and NLRP3 promoters. Overexpression of CASP1 resulted in cleavage of the glucocorticoid receptor, diminished the glucocorticoid-induced transcriptional response and increased glucocorticoid resistance. Knockdown or inhibition of CASP1 significantly increased glucocorticoid receptor levels and mitigated glucocorticoid resistance in CASP1-overexpressing ALL. Our findings establish a new mechanism by which the NLRP3-CASP1 inflammasome modulates cellular levels of the glucocorticoid receptor and diminishes cell sensitivity to glucocorticoids. The broad impact on the glucocorticoid transcriptional response suggests that this mechanism could also modify glucocorticoid effects in other diseases

A roadmap to the efficient and robust characterization of temperate terrestrial planet atmospheres with JWST

Ultra-cool dwarf stars are abundant, long-lived, and uniquely suited to enable the atmospheric study of transiting terrestrial companions with JWST. Amongst them, the most prominent is the M8.5V star TRAPPIST-1 and its seven planets, which have been the favored targets of eight JWST Cycle 1 programs. While Cycle 1 observations have started to yield preliminary insights into the planets, they have also revealed that their atmospheric exploration requires a better understanding of their host star. Here, we propose a roadmap to characterize the TRAPPIST-1 system -- and others like it -- in an efficient and robust manner. We notably recommend that -- although more challenging to schedule -- multi-transit windows be prioritized to constrain stellar heterogeneities and gather up to 2$\times$ more transits per JWST hour spent. We conclude that in such systems planets cannot be studied in isolation by small programs, thus large-scale community-supported programs should be supported to enable the efficient and robust exploration of terrestrial exoplanets in the JWST era

WASP-193b: An extremely low-density super-Neptune

Gas giants transiting bright nearby stars are stepping stones for our understanding of planetary system formation and evolution mechanisms. This paper presents a particularly interesting new specimen of this kind of exoplanet discovered by the WASP-South transit survey, WASP-193b. This planet completes an orbit around its Vmag = 12.2 F9 main-sequence host star every 6.25 d. Our analyses found that WASP-193b has a mass of Mp = 0.139 +/- 0.029 M_Jup and a radius of Rp = 1.464 +/- 0.058 R_ Jup, translating into an extremely low density of rhop = 0.059 +\- 0.014 g/cm^3. The planet was confirmed photometrically by the 0.6-m TRAPPIST-South, the 1.0-m SPECULOOS-South telescopes, and the TESS mission, and spectroscopically by the ESO-3.6-m/HARPS and Euler-1.2-m/CORALIE spectrographs. The combination of its large transit depth (dF~1.4 %), its extremely-low density, its high-equilibrium temperature (Teq = 1254 +/- 31 K), and the infrared brightness of its host star (magnitude Kmag=10.7) makes WASP-193b an exquisite target for characterization by transmission spectroscopy (transmission spectroscopy metric: TSM ~ 600). One single JWST transit observation would yield detailed insights into its atmospheric properties and planetary mass, within ~0.1 dex and ~1% (vs ~20% currently with radial velocity data) respectively

TESS discovery of a sub-Neptune orbiting a mid-M dwarf TOI-2136

peer reviewedWe present the discovery of TOI-2136b, a sub-Neptune planet transiting every 7.85 days a nearby M4.5V-type star, identified through photometric measurements from the TESS mission. The host star is located $33$ pc away with a radius of $R_{\ast} = 0.34\pm0.02\ R_{\odot}$, a mass of $0.34\pm0.02\ M_{\odot}$ and an effective temperature of $\rm 3342\pm100\ K$. We estimate its stellar rotation period to be $75\pm5$ days based on archival long-term photometry. We confirm and characterize the planet based on a series of ground-based multi-wavelength photometry, high-angular-resolution imaging observations, and precise radial velocities from CFHT/SPIRou. Our joint analysis reveals that the planet has a radius of $2.19\pm0.17\ R_{\oplus}$, and a mass measurement of $6.4\pm2.4\ M_{\oplus}$. The mass and radius of TOI2136b is consistent with a broad range of compositions, from water-ice to gas-dominated worlds. TOI-2136b falls close to the radius valley for low-mass stars predicted by the thermally driven atmospheric mass loss models, making it an interesting target for future studies of its interior structure and atmospheric properties