2 research outputs found
Iodine-Mediated Intramolecular Dehydrogenative Coupling: Synthesis of <i>N</i>‑Alkylindolo[3,2‑<i>c</i>]- and -[2,3‑<i>c</i>]quinoline Iodides
An I<sub>2</sub>/TBHP-mediated intramolecular
dehydrogenative coupling
reaction is developed for the synthesis of a library of medicinally
important 5,11-dialkylindolo[3,2-<i>c</i>]quinoline salts
and 5,7-dimethylindolo[2,3-<i>c</i>]quinoline salts. The
annulation reaction is followed by aromatization to yield tetracycles
in good yield. This protocol is also demonstrated for the synthesis
of the naturally occurring isocryptolepine in salt form