Effect of sildenafil on IUGR

Background: IUGR is one of the major culprit of perinatal mortality and morbidity in India, with reported incidence of 21-28%. Objective of present study is to investigate the effect of sildenafil on pregnancies complicated with IUGR and to see its effect on fetal outcome.Methods: This was a case control study conducted after clearance of Ethical Committee of the Institute from July 2014 to July 2016 in Department of Obstetrics and Gynecology of Dr. B.R.A.M. Hospital, Raipur [C.G.]. All women with pregnancies complicated with IUGR were identified and included in study. According to treatment with Sildenafil women were divided in two groups. Both groups were followed up till delivery and their outcome including birth weight, AC and complications related to IUGR were compared.Results: IUGR was found to be more prevalent in primi gravidas and women of lower socioeconomic and educational status with low BMI.  We found Hypertension in pregnancy as significant causative factor precipitating the IUGR [68%]. In sildenafil treated group significant 63% mothers had baby with birth weight >10 percentile whereas in sildenafil non treated group only 20% had > 10 percentile birth weight. The mean birth weight of Sildenafil treated group was 2594gm whereas in non-treated group it was 2200gm.  In our study, we observed improved AC in 70% whereas in control group improvement was only in 34% which was significant.Conclusions: Sildenafil was found to improves birth weight, abdominal circumference, and reduce the complications related to IUGR

The tranexamic acid: as chemical tourniquet during Ward-Mayo’s operation

Background: The intra-operative blood loss which required transfusion is one of the complications in Ward-Mayo’s operation. The objective of this study was to evaluate its effectiveness to minimizes hemorrhage in Ward-Mayo’s operationMethods: It is a well-designed, Clinical, interventional, prospective, randomized control trial. In the department of obstetrics and gynecology, IPGMER-SSKM (PG) H, Kolkata, West Bengal, India. More than one-year study. After ethics approval, the total number of sixty-six cases will be selected with randomization for Ward-Mayo operation and allocated into two groups operated as - Gr-A (n = 33 cases) - by infiltrating locally tranexaminic acid, Gr-B (n = 33-controls) - application local conventional haemostatics.Results: The outcome informs of primary and secondary assessed, analyzed, tabulated and statistically significant showed accordingly as per graph pad software. In Table 1 and 2. The results of individual group (Gr. A and Gr. B) in forms of pry and Sec. outcomes showed that there are better outcomes in all aspects with zero mortality Tranexamic group than controls.Conclusions: This study concluded that the Tranexamic Acid can safely and effectively used by local infiltration during Ward-Mayo’ operation. Like other department, this technique can be utilized in other vaginal procedure (ex-Episiotomy)

Reproducibility of “The bethesda system for reporting thyroid cytopathology:” A retrospective analysis of 107 patients

Objectives: Fine-needle aspiration cytology (FNAC) has emerged as an indispensable tool to discriminate thyroid lesions into benign or malignant for appropriate management. The need for simplicity of communication and standardization of terminology for thyroid FNAC reporting led to introduction of “The Bethesda system for reporting Thyroid Cytopathology” (TBSRTC) in a conference held at the National Cancer Institute in 2007. This study aims at establishing the reproducibility of TBSRTC for diagnosing thyroid lesions. Materials and Methods: The present study comprised thyroid FNAC from 107 patients retrospectively over a period of 1.5 year (June 2013 to December 2014), which were reviewed by two trained cytopathologists and re-categorized according to TBSRTC. The interobserver variation and reproducibility of the reporting system was statistically assessed using Cohen's kappa. Results: The cytopathologists were in agreement in 98 out of 107 cases (91.5%). Maximum concordance was noted in benign category (91 of 96 cases; 92.85%), followed by 2 cases each in nondiagnostic/unsatisfactory (ND/US) and follicular neoplasm/suspicious for follicular neoplasm (FN/SFN) category (2.04% each) and 1 case each in atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS), suspicious for malignancy (SUS), and malignant category (1.02% each). The highest diagnostic disagreement was noted among ND/US and benign and benign and FN/SFN categories. Conclusion: The utilization of TBSRTC for reporting thyroid cytology should be promoted in our country because it provides a homogeneous, standardized, and unanimous terminology for cytological diagnosis of thyroid lesions. The present study could substantiate the diagnostic reproducibility of this system

Temporally and spatially resolved molecular profiling in fingerprint analysis using indium vanadate nanosheets-assisted laser desorption ionization mass spectrometry

Abstract This study presents the first-ever synthesis of samarium-doped indium vanadate nanosheets (IVONSs:Sm) via microemulsion-mediated solvothermal method. The nanosheets were subsequently utilized as a nano-matrix in laser desorption/ionization mass spectrometry (LDI-MS). It was discovered that the as-synthesized IVONSs:Sm possessed the following advantages: improved mass spectrometry signal, minimal matrix-related background, and exceptional stability in negative-ion mode. These qualities overcame the limitations of conventional matrices and enabled the sensitive detection of small biomolecules such as fatty acids. The negative-ion LDI mechanism of IVONSs:Sm was examined through the implementation of density functional theory simulation. Using IVONSs:Sm-assisted LDI-MS, fingerprint recognitions based on morphology and chemical profiles of endogenous/exogenous compounds were also achieved. Notably, crucial characteristics such as the age of an individual’s fingerprints and their physical state could be assessed through the longitudinal monitoring of particular biomolecules (e.g., ascorbic acid, fatty acid) or the specific biomarker bilirubin glucuronide. Critical information pertinent to the identification of an individual would thus be facilitated by the analysis of the compounds underlying the fingerprint patterns. Graphical Abstrac

Additional file 1 of Temporally and spatially resolved molecular profiling in fingerprint analysis using indium vanadate nanosheets-assisted laser desorption ionization mass spectrometry

Supplementary Material 1: Experimental section and additional data (Figure S1–S25, Table S1–S4) associated with this article can be found in the online versio