Intelligibility Enhancement of Synthetic Speech: A Review

Current method of speech enhancement has been developed with adaptive filtering approach. The adaptive filter utilizes the least mean square algorithm for noise removal, but in LMS algorithm key parameter is step size. When step size is large speed and least mean square error is large and it is that computational cost increases to an undesirable level as the length of the impulse response increases. This paper provide a detail review on existing methodologies on enhancement on synthetic speech

Compact stars within an asy-soft quark-meson-coupling model

We investigate compact star properties within the quark meson coupling model (QMC) with a soft symmetry energy density dependence at large densities. In particular, the hyperon content and the mass/radius curves for the families of stars obtained within the model are discussed. The hyperon-meson couplings are chosen according to experimental values of the hyperon nuclear matter potentials, and possible uncertainties are considered. It is shown that a softer symmetry energy gives rise to stars with less hyperons, smaller radii and larger masses. Hyperon-meson couplings may also have a strong effect on the mass of the star.Comment: 7 pages, revtex, accepted in Phys. Rev.

Management of phyllodes tumour (Arbuda): A case report

Breast lumps of benign types are the commonest type of breast disease amongst 40 per cent of female population. The chances of the growth being malignant make patients apprehensive. Phyllodes tumour involving the stroma of the breast is a common among females of around 40 years of age. Acharya Sushruta has advised Chedana of Arbuda i.e. excision of tumour to avoid recurrence. Considering the chances of recurrence surgical treatment of phyllodes is successful if excision is clubbed with mastectomy of the surrounding breast tissue. A 65 years woman suffering from breast lump for 2 years was diagnosed with Phyllodes tumour clinically as well as with radiological aids. Malignancy was ruled out as per diagnostic criteria. Excision of the lump with 1cm margins was carried out as per surgery protocol. Biopsy report confirmed the diagnosis of benign phyllodes tumour. Patient has been stable since last one and a half year and recurrence has not been noticed. Thus, it can be concluded that an organised approach towards benign lesion like phyllodes tumour can help to alleviate anxiety and fear of patients

A Review Paper on Classification of Stem Cell Transplant to Identify the High Survival Rate

A patient undergoing hematopoietic stem cell transplant faces various risk factors and has become the standard of care for congenital or acquired disorders of the hematopoietic system or with chemo-sensitive, radiosensitive or immunosensitive malignancies. Analyzing and classifying the data from past transplant can enhance the understanding of the factors leading to highest survival rates among the patients. Over the last few decades there has been tremendous use of technology in this field. Stem cell transplant remains a dangerous procedure as it requires significant infrastructure and a network of specialists from all fields of medicine. In this paper, we are using a classification algorithm known as Support Vector Machine to classify the patients who have undergone stem cell transplant with high odds of survival. We are also keeping track of information about the donors within the family and outside the family which has a direct impact in the prioritization of resources. Classification of this information is useful to create the need for a global perspective for all cell, tissue, and organ transplants and to reveal statistical structure with potential implications in evidence-based prioritization of resources. Machine-learning techniques proved useful in analyzing the correct data from various datasets as this techniques were previously been considered too complex to analyze. DOI: 10.17762/ijritcc2321-8169.16043

Prevalence of metabolic syndrome in a rural population- a cross sectional study from Western Uttar Pradesh, India

Background: Prevalence of non-communicable diseases like hypertension, diabetes mellitus and coronary artery disease is on the rise due to the change in lifestyle, unfavourable dietary habits and obesity. Metabolic syndrome is a simple tool by which we can predict the future risk of diabetes mellitus and cardiovascular disease. Studies showed that prevalence of metabolic syndrome is rising in Indian population, but majority of them were done in urban population. This study was conducted to look into the current status of the metabolic syndrome in rural population.Methods: The study was conducted among a population of 2982. Each participant was subjected to clinical examination, anthropometric measurements and necessary laboratory investigations. Metabolic syndrome was diagnosed based on modified NCEP: ATP III criteria.Results: The prevalence of metabolic syndrome was found to be 11.7% and was higher among female population (13.8%) as compared to males (9.6%). The prevalence of metabolic syndrome increased with increasing age. 28.3% of the participants over the age of 50 years had metabolic syndrome whereas it was only 0.4% below the age of 20 years. Nearly half (47.1%) of the obese individuals were suffering from metabolic syndrome implicating obesity as one of the most important risk factors in the etiopathogenesis of metabolic syndrome. The prevalence was only 1.1% among the underweight group.Conclusions: Present study has shown moderate prevalence of metabolic syndrome among the rural population of Western Uttar Pradesh, India with a more female predisposition

Isolated single coronary artery (RII-B type) presenting as an inferior wall myocardial infarction: A rare clinical entity

AbstractIsolated single coronary artery without other congenital cardiac anomalies is very rare among the different variations of anomalous coronary patterns. The prognosis in patients with single coronary varies according to the anatomic distribution and associated coronary atherosclerosis. If the left main coronary artery travels between the aorta and pulmonary arteries, it may be a cause of sudden cardiac death. We present multimodality images of a single coronary artery, in which the whole coronary system originated by a single trunk from the right sinus of Valsalva with inter-arterial course of left main coronary artery. This rare type of single coronary artery was classified as RII-B type according to Lipton's scheme of classification. A significant flow-limiting lesions were found in the right coronary artery that was successfully treated with percutaneous coronary intervention

Synthesis, Characterization and Quantification of Simvastatin Metabolites and Impurities

Simvastatin is used in treatment of hypercholesterolemia because it regulates cholesterol synthesis as a result of its β-hydroxy acid acting as an inhibitor of 3-hydroxy-methylglutaryl coenzyme A (HMG-CoA). The present communication deals with synthesis, characterization and development of accurate, precise and sensitive Reverse Phase High Performance Liquid Chromatography (RP-HPLC) method for simultaneous estimation of simvastatin and its synthetic impurities. The impurities methyl ether and β-hydroxy acid of simvastatin were synthesized in the laboratory and characterized by MS, NMR and FT-IR spectroscopy. The separation of simvastatin and its impurities was carried out on an isocratic JASCO RP-HPLC system using KYA TECH HIQ SIL C18 column (150 × 4.6 mm internal diameter, particle size 5 μm) operating at ambient temperature using acetonitrile:water (80:20 v/v) with 0.1% orthophosphoric acid as mobile phase. The method developed for HPLC analysis of three impurities along with simvastatin was validated using ICH Q2B (R1) guidelines and it complied with these guidelines. The results of analysis were found to be in the range of 98.14% to 101.89% for all analytes with acceptable accuracy and precision. The method can be used for detection and quantification of synthetic impurities in bulk or formulations of simvastatin

Prevalence of type 2 diabetes mellitus in rural population of India- a study from Western Uttar Pradesh

Background: Diabetes is a major challenge for a resource-limited country like India. Majority of the patients are diagnosed late in the course of illness with presence of complications. There is limited data on diabetes from rural India. Present study is an attempt to provide data on diabetes in rural India. The overall objective of present study was to estimate the prevalence of Type 2 diabetes mellitus in rural population above 25 years age in district Etawah and neighbouring areas of Uttar Pradesh, India.Methods: The study was planned to determine the prevalence of diabetes mellitus in rural community by health camp and door to door approach. Fasting capillary blood glucose was first determined using a glucose meter (SD check code free, SD biosensor Inc. Korea). All the adults were given 75gm of glucose dissolved in 200ml water which was drunk over a period of up to 5 minutes and the 2-hour post load capillary blood glucose was estimated. Diabetic status was confirmed by taking blood samples for fasting and postprandial blood sugar levels in a fluoride vacutainer. Fasting plasma glucose ≥126mg/dl and or 2-hour postprandial glucose ≥200mg/dl were taken as the diagnostic criteria for diagnosis.Results: Prevalence of type 2 diabetes in the rural population was found to be 8.03%. Prevalence was higher in female population (9.91%) as compared to males (6.79%). 19.74 % of participants over 70 yrs of age were diabetics while diabetes was present only in 2.95% of participants in the age group of 25-39 year. The maximum number of diabetes were in the age group of 50-59 years. 10.04 % of participants were diagnosed to be Prediabetics. 35.77% of the diabetics were newly diagnosed.Conclusions:Present study shows there is high prevalence of type 2 diabetes in rural area of western Uttar Pradesh, India.