Bronchogenic Carcinoma in a Scleroderma Patient with Multiple Metastases: One Case Report

The association between pulmonary interstitial fibrosis and the developmentof bronchogenic carcinoma in a patient with sclerodermahas been reported rarely[1]. It is hypothesized that intense epithelialproliferation that is accompanied by the fi brotic process increases theoccurrence of carcinomatous changes[2]. We report the case of a patientwho presented with 3-year history of Raynaud’s phenomenon,gradual tightening of the skin which was ignored by the patient andher family members, and a 2-week history of severe respiratory distresswith left shoulder and upper back pain followed by the developmentof paraparesis. After a series of examinations, the patient wasdiagnosed with scleroderma and simultaneously with bronchogeniccarcinoma and multiple distant metastases

Primary Pleural Extranodal Non-Hodgkin’s Lymphoma Presenting As Pleural Thickening—A Case Report

Primary pleural lymphoma is a rare entity that has been described in association with human immunodeficiency virus (HIV) infection or pyothorax. This paper reports on a 27 year old man with no history of HIV infection or pyothorax who presented with progressive dyspnea and heaviness of chest. Chest radiography revealed complete opacification of the left hemithorax, and contrast enhanced computed tomography showed large left pleural effusion and homogeneous, extensive thickening of the parietal pleura. CT guided biopsy of thickened pleura is suggestive of non-Hodgkin’s lymphoma-T cell lymphoblastic variety. Physicians should be aware of this rare location of primary pleural lymphoma manifested by thickening of the pleura

Deep vein thrombosis in a patient of adenomatous polyposis coli treated successfully with aspirin: A case report

Background: Deep vein thrombosis is an important cause of morbidity and mortality. However, its association with adenomatous polyposis coli is extremely rare. Here we present an interesting case of deep vein thrombosis associated with adenomatous polyposis coli. Case Presentation: A 15 year old female who was having fever and diarrhea for 5 months developed bilateral asymmetric painful swelling of lower limbs for 1 month. Doppler ultrasound of lower limbs revealed presence of thrombosis from inferior vena cava up to popliteal vein. Colonoscopy and biopsy were suggestive of adenomatous polyposis coli. However, she could not tolerate anticoagulant therapy and was put on aspirin therapy for 6 months to which she responded well with the resolution of thrombus. Conclusion: Role of aspirin therapy may be considered whenever a patient of venous thrombosis cannot tolerate anticoagulant therap

Single Nucleotide Polymorphism Network: A Combinatorial Paradigm for Risk Prediction

<div><p>Risk prediction for a particular disease in a population through SNP genotyping exploits tests whose primary goal is to rank the SNPs on the basis of their disease association. This manuscript reveals a different approach of predicting the risk through network representation by using combined genotypic data (instead of a single allele/haplotype). The aim of this study is to classify diseased group and prediction of disease risk by identifying the responsible genotype. Genotypic combination is chosen from five independent loci present on platelet receptor genes <i>P2RY1</i> and <i>P2RY12</i>. Genotype-sets constructed from combinations of genotypes served as a network input, the network architecture constituting super-nodes (e.g., case and control) and nodes representing individuals, each individual is described by a set of genotypes containing M markers (M = number of SNP). The analysis becomes further enriched when we consider a set of networks derived from the parent network. By maintaining the super-nodes identical, each network is carrying an independent combination of M-1 markers taken from M markers. For each of the network, the ratio of case specific and control specific connections vary and the ratio of super-node specific connection shows variability. This method of network has also been applied in another case-control study which includes oral cancer, precancer and control individuals to check whether it improves presentation and interpretation of data. The analyses reveal a perfect segregation between super-nodes, only a fraction of mixed state being connected to both the super-nodes (i.e. common genotype set). This kind of approach is favorable for a population to classify whether an individual with a particular genotypic combination can be in a risk group to develop disease. In addition with that we can identify the most important polymorphism whose presence or absence in a population can make a large difference in the number of case and control individuals.</p> </div

The strategy of our work is described by the illustration.

<p>The chart shows the strategy employed in the present analysis. The way of doing the whole analyses is described sequentially through the chart. The methods involved in the network based analysis and further the consistency of the outcome of Network based approach and the conventional statistical methods are also described.</p