7 research outputs found
Studies on the lithiation, borylation, and 1,2‐metalate rearrangement of O‐cycloalkyl 2,4,6‐triisopropylbenzoates
CCDC 1557929: Experimental Crystal Structure Determination
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures
CCDC 1557928: Experimental Crystal Structure Determination
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures
Synthesis of 6- and 7‑Membered <i>N</i>‑Heterocycles Using α‑Phenylvinylsulfonium Salts
A concise synthesis of stereodefined <i>C</i>-substituted
morpholines, piperazines, azepines, and oxazepines in moderate to
excellent yields (27% to 75%) is reported by reaction of 1,2- or 1,3-amino
alcohol/1,2- or 1,3-diamine with an α-phenylvinylsulfonium salt.
High levels of regio- and diastereoselectivity (from 2:1 to >20:1)
are observed through judicious choice of base (Cs<sub>2</sub>CO<sub>3</sub>) and solvent (CH<sub>2</sub>Cl<sub>2</sub>). Reactions are
performed at ambient temperature and open to air and do not require
anhydrous solvent. The deprotection of the <i>N</i>-sulfonamide
protecting groups (<i>N</i>-Ts and <i>N</i>-Ns)
is also demonstrated. Factors affecting regio- and diastereocontrol
are discussed