Effect of shape anisotropy on transport in a 2-dimensional computational model: Numerical simulations showing experimental features observed in biomembranes

We propose a 2-d computational model-system comprising a mixture of spheres and the objects of some other shapes, interacting via the Lennard-Jones potential. We propose a reliable and efficient numerical algorithm to obtain void statistics. The void distribution, in turn, determines the selective permeability across the system and bears a remarkable similarity with features reported in certain biological experiments.Comment: 1 tex file, 2 sty files and 5 figures. To appear in Proc. of StatPhys conference held in Calcutta, Physica A 199

Systems Thinking Perspective on Support for Transition and Acceptance of Identity of Chronic Health Disease Patient in Society

Currently, India is home to diabetes, and it has the second-largest diabetic population in the world. The term ‘health seeker’ is used instead of the patient since the health seeker is attributed to a person who is motivated to improve his physical and mental well-being (Bate, P. & Rober, G., 2007). Diabetes is a chronic disease that requires the health seeker to modify their lifestyle, which is a transition of their identity. This transition from a healthy self to a chronic health disease health seeker is often challenged by societal forces and healthcare services. While the patient experiences are personal, the healthcare systems are abstract and impersonal. With the systems thinking approach, the questions we are trying to seek answers to are: Where does the boundary of healthcare begin and end for a patient with chronic health disease? What are the insensitivities faced by the health seeker while experiencing a chronic health condition such as diabetes? What are the support systems that help health seekers in their journey of new medical identity across space and various life activities

Changing trends in circulating rotavirus strains in Pune, western India in 2009–2012: Emergence of a rare G9P[4] rotavirus strain

AbstractBackgroundA vast diversity in rotaviruses at inter- and intra-genotypic level underscores the need for monitoring of circulating rotavirus strains. The aim of this study was to update the data on rotavirus disease and strains for the period from January 2009 to December 2012 in Pune, western India which has been one of the sites of the Indian Rotavirus Strain Surveillance Network since November 2005.MethodsChildren aged <5 years admitted for acute gastroenteritis in three different hospitals from Pune city were included in the study. The stool specimens were collected and tested for rotavirus antigen by a commercial enzyme immunoassay. The rotavirus strains were genotyped by multiplex reverse transcription polymerase chain reaction.ResultsDuring the study period, we found 35.1% of 685 stool specimens contained rotavirus antigen. Frequency of rotavirus detection was greatest (58.5%) among children aged 7–12 months. The G1P[8] (31.4%), G2P[4] (20.2%) and G9P[8] (11.8%) strains were the most common types. We noted predominance of G1P[8] strains (39.6%-46.1%) in all the years of study except 2009 wherein G9P[8] strains scored highest level (15.3%). Subsequent to this, we identified G9P[8] strains at the second highest position in 2010, their sudden decline and rise in G9P[4] strains in 2011–2012. We detected G12 strains in combination with P[6] and P[8] at variable rates (0–10.2%) and highest level (27.1%) of mixed rotavirus infections in 2009 as compared to 2010–2012 (0–3.8%).ConclusionThe study highlights the huge burden of rotavirus disease and changing profile of circulating rotavirus strains displaying emergence of G9P[4] reassortant strains in Pune, western India and emphasizes the need to analyze the entire genomic constellation of rotavirus strains for better evaluation of the impact of rotavirus

Smartpixels: Towards on-sensor inference of charged particle track parameters and uncertainties

The combinatorics of track seeding has long been a computational bottleneck for triggering and offline computing in High Energy Physics (HEP), and remains so for the HL-LHC. Next-generation pixel sensors will be sufficiently fine-grained to determine angular information of the charged particle passing through from pixel-cluster properties. This detector technology immediately improves the situation for offline tracking, but any major improvements in physics reach are unrealized since they are dominated by lowest-level hardware trigger acceptance. We will demonstrate track angle and hit position prediction, including errors, using a mixture density network within a single layer of silicon as well as the progress towards and status of implementing the neural network in hardware on both FPGAs and ASICs.Comment: 6 pages, 3 figures, submitted to Neural Information Processing Systems 2023 (NeurIPS

Teaching and curiosity: sequential drivers of cumulative cultural evolution in the hominin lineage

Many animals, and in particular great apes, show evidence of culture, in the sense of having multiple innovations in multiple domains whose frequencies are influenced by social learning. But only humans show strong evidence of complex, cumulative culture, which is the product of copying and the resulting effect of cumulative cultural evolution. The reasons for this increase in complexity have recently become the subject of extensive debate. Here, we examine these reasons, relying on both comparative and paleoarcheological data. The currently best-supported inference is that culture began to be truly cumulative (and so, outside the primate range) around 500,000 years ago. We suggest that the best explanation for its onset is the emergence of verbal teaching, which not only requires language and thus probably coevolved with the latter’s evolution but also reflects the overall increase in proactive cooperation due to extensive allomaternal care. A subsequent steep increase in cumulative culture, roughly 75 ka, may reflect the rise of active novelty seeking (curiosity), which led to a dramatic range expansion and steep increase in the diversity and complexity of material culture. A final, and continuing, period of acceleration began with the Neolithic (agricultural) revolution

A model for tool-use traditions in primates: implications for the coevolution of culture and cognition

Inspired by the demonstration that tool-use variants among wild chimpanzees and orangutans qualify as traditions (or cultures), we developed a formal model to predict the incidence of these acquired specializations among wild primates and to examine the evolution of their underlying abilities. We assumed that the acquisition of the skill by an individual in a social unit is crucially controlled by three main factors, namely probability of innovation, probability of socially biased learning, and the prevailing social conditions (sociability, or number of potential experts at close proximity). The model reconfirms the restriction of customary tool use in wild primates to the most intelligent radiation, great apes; the greater incidence of tool use in more sociable populations of orangutans and chimpanzees; and tendencies toward tool manufacture among the most sociable monkeys. However, it also indicates that sociable gregariousness is far more likely to produce the maintenance of invented skills in a population than solitary life, where the mother is the only accessible expert. We therefore used the model to explore the evolution of the three key parameters. The most likely evolutionary scenario is that where complex skills contribute to fitness, sociability and/or the capacity for socially biased learning increase, whereas innovative abilities (i.e., intelligence) follow indirectly. We suggest that the evolution of high intelligence will often be a byproduct of selection on abilities for socially biased learning that are needed to acquire important skills, and hence that high intelligence should be most common in sociable rather than solitary organisms. Evidence for increased sociability during hominin evolution is consistent with this new hypothesis. (C) 2003 Elsevier Science Ltd. All rights reserved

Why Class Formation Occurs in Humans but Not among Other Primates

Most human societies exhibit a distinct class structure, with an elite, middle classes, and a bottom class, whereas animals form simple dominance hierarchies in which individuals with higher fighting ability do not appear to form coalitions to “oppress” weaker individuals. Here, we extend our model of primate coalitions and find that a division into a bottom class and an upper class is inevitable whenever fitness-enhancing resources, such as food or real estate, are exploitable or tradable and the members of the bottom class cannot easily leave the group. The model predicts that the bottom class has a near flat, low payoff and always comprises at least half the society. The upper class may subdivide into one or more middle class(es), resulting in improved payoff for the topmost members (elite). The model predicts that the bottom class on its own is incapable of mounting effective counter-coalitions against the upper class, except when receiving support from dissatisfied members of the middle class(es). Such counter-coalitions can be prevented by keeping the payoff to the lowest-ranked members of the middle classes (through concessions) well above that of the bottom class. This simple model explains why classes are also absent in nomadic hunter-gatherers and predominate in (though are not limited to) societies that produce and store food. Its results also agree well with various other known features of societies with classes

Shape anisotropy of lipid molecules and voids

Biological polymers, viz., proteins, membranes and micelles exhibit structural discontinuities in terms of spaces unfilled by the polymeric phase, termed voids. These voids exhibit dynamics and lead to interesting properties which are experimentally demonstrable. In the specific case of phospholipid membranes, numerical simulations on a two-dimensional model system showed that voids are induced primarily due to the shape anisotropy in binary mixtures of interacting disks. The results offer a minimal description required to explain the unusually large permeation seen in liposomes made up of specific lipid mixtures (Mathai &amp; Sitaramam, 1994). The results are of wider interest, voids being ubiquitous in biopolymers