Study Of Reactive Power Compensation Using STATCOM

The study of shunt connected FACTS devices is a connected field with the problem of reactive power compensation and better mitigation of transmission related problems in today’s world. In this paper we study the shunt operation of FACTS controller, the STATCOM, and how it helps in the better utilization of a network operating under normal conditions. First we carry out a literature review of many papers related to FACTS and STATCOM, along with reactive power control. Then we look at the various devices being used for both series and shunt compensation. The study of STATCOM and its principles of operation and control, including phase angle control and PWM techniques, are carried out. We also delve into the load flow equations which are necessary for any power system solution and carry out a comprehensive study of the Newton Raphson method of load flow. Apart from this, we also carry out a study of the transient stability of power systems, and how it is useful in determining the behavior of the system under a fault. As an example, a six bus system is studied using the load flow equations and solving them. First this is done without the STATCOM and then the STATCOM is implemented and the characteristics of the rotor angle graph along with faults at various buses are seen. In this thesis, it is tried to show the application of STATCOM to a bus system and its effect on the voltage and angle of the buses. Next the graphs depicting the implemented STATCOM bus are analyzed and it is shown that the plots of the rotor angles show a changed characteristic under the influence of the STATCOM

Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTIC‐HF: baseline characteristics and comparison with contemporary clinical trials

Aims: The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTIC‐HF) trial. Here we describe the baseline characteristics of participants in GALACTIC‐HF and how these compare with other contemporary trials. Methods and Results: Adults with established HFrEF, New York Heart Association functional class (NYHA) ≥ II, EF ≤35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokinetic‐guided dosing: 25, 37.5 or 50 mg bid). 8256 patients [male (79%), non‐white (22%), mean age 65 years] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NT‐proBNP 1971 pg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTIC‐HF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressure < 100 mmHg (n = 1127), estimated glomerular filtration rate < 30 mL/min/1.73 m2 (n = 528), and treated with sacubitril‐valsartan at baseline (n = 1594). Conclusions: GALACTIC‐HF enrolled a well‐treated, high‐risk population from both inpatient and outpatient settings, which will provide a definitive evaluation of the efficacy and safety of this novel therapy, as well as informing its potential future implementation

Race, politics, and armies: The dynamics of military modernization in twentieth-century colonial India

During the first half of the twentieth century the colonial Indian army underwent a dramatic transition. What had hitherto been a predominantly glorified colonial police force was transformed into a relatively modern army, complete with its own institutionalized officer corps. This impressive achievement was the culmination of a complex, if cautious, program of military modernization and has practically been ignored by the historiography on the colonial Indian army. The scant work that has been done tends to underplay this crucial development. This dissertation analyses some of these neglected institutional and organizational reforms.Institutional reform refers to the development of a professional officer corps along with the training establishments that sustain such a cadre; organizational reform refers to the structural and doctrinal evolution of the colonial Indian army. This study demonstrates that the dynamics of colonial military modernization in India was a complex process of interaction, involving British with Indian and British with British. The end result of which was the creation of a highly professional national army, one of the few in the developing world to be untainted by involvement in politics.U of I OnlyETDs are only available to UIUC Users without author permissio

Colonial Ideologies and the Emergence of Two Spaces: The Nigerian Experience

This chapter examines the politico-historical emergence of two spaces in colonial Nigeria and how this historical configuration affected colonial and postcolonial Nigerian politics. It contends that the emergence and characteristics of the two spaces owe their origins to two bourgeois groups, namely the British colonial administrators on ground and the select few indigenous elite borne out of the colonial experience. Ideologies were formulated around these two groups and used to legitimate British rule as the ordinary man became the target of the intellectual workmanship of the two groups. The chapter concludes that the postcolonial challenges of Nigeria are due to the dialectical relationship between the two spaces which emerged out of the need to execute the imperial ideologies of Britain in colonial Nigeria

Refolding and simultaneous purification by three-phase partitioning of recombinant proteins from inclusion bodies

Many recombinant eukaryotic proteins tend to form insoluble aggregates called inclusion bodies, especially when expressed in Escherichia coli. We report the first application of the technique of three-phase partitioning (TPP) to obtain correctly refolded active proteins from solubilized inclusion bodies. TPP was used for refolding 12 different proteins overexpressed in E. coli. In each case, the protein refolded by TPP gave either higher refolding yield than the earlier reported method or succeeded where earlier efforts have failed. TPP-refolded proteins were characterized and compared to conventionally purified proteins in terms of their spectral characteristics and/or biological activity. The methodology is scaleable and parallelizable and does not require subsequent concentration steps. This approach may serve as a useful complement to existing refolding strategies of diverse proteins from inclusion bodies

Cocrystals by Design: A Rational Coformer Selection Approach for Tackling the API Problems

Active pharmaceutical ingredients (API) with unfavorable physicochemical properties and stability present a significant challenge during their processing into final dosage forms. Cocrystallization of such APIs with suitable coformers is an efficient approach to mitigate the solubility and stability concerns. A considerable number of cocrystal-based products are currently being marketed and show an upward trend. However, to improve the API properties by cocrystallization, coformer selection plays a paramount role. Selection of suitable coformers not only improves the drug’s physicochemical properties but also improves the therapeutic effectiveness and reduces side effects. Numerous coformers have been used till date to prepare pharmaceutically acceptable cocrystals. The carboxylic acid-based coformers, such as fumaric acid, oxalic acid, succinic acid, and citric acid, are the most commonly used coformers in the currently marketed cocrystal-based products. Carboxylic acid-based coformers are capable of forming the hydrogen bond and contain smaller carbon chain with the APIs. This review summarizes the role of coformers in improving the physicochemical and pharmaceutical properties of APIs, and deeply explains the utility of afore-mentioned coformers in API cocrystal formation. The review concludes with a brief discussion on the patentability and regulatory issues related to pharmaceutical cocrystals