Evaluasi Penggunaan Antibiotika Profilaksis Dari Aspek Ketepatan Jenis, Waktu Dan Durasi Pemberian Pada Pasien Instalasi Bedah Sentral Sebuah Rumah Sakit Swasta Di YOGYAKARTA

Surgical site infection is one of surgical infection that frequently happened in hospital sothat the use of antibiotic prophylaxis must be safe. The research was conducted to know incidenceof adverse event at USAge of antibiotic prophylaxis in surgery installation. We use concordancesheet of antibiotic prophylaxis either from accuracy aspect of the drug type, administration time,duration of USAge. Result analysis in the form of calculation relative risk of USAge of antibioticdissected pre prophylaxis to risk the happening of surgical site infections cases. Result thisresearch show that relative risk value of USAge of antibiotic to case of infection of operation hurtevaluated from inaccurate of type antibiotic 1,12 ( CI 95 %: 0,138-9,1), inaccurate aspect of gift time5,8 ( CI 95 % : 1,024 - 32,86) and from inaccurate aspect of duration of gift 3,21 ( CI 95 % : 1,043 -9,9)

Potential of Red Spinach Leaves Ethanolic Extract (Amaranthus Tricolor L.) as a Complementary Therapy for Hiperlipidemia: Study in Vivo of Histopathologic and Activity of Alanin Aminotransferase (ALT)

This study was conducted to determine the potential of ethanolic extract of red spinach leaves (Amaranthus tricolor L.) with control quality as a complementary treatment of hyperlipidemic based on histopathology and activity of alanin aminotrasferase (ALT). A total of 24 male Wistar rats were randomized in 6 groups: normal group; positive control group were given the drug simvastatin; negative control group; 1st treatment group was given extract at dose of 400mg/kgBW rat, 2nd group was given extract at dose of 400mg/kgBW rat and simvastatin dose 0.18 mg/kgBW rat; 3rd treatment groups were given extract at dose of 800mg/kgBW rat and simvastatin dose 0.18 mg/kgBW rat. Induction hyperlipidemic using high fat diet and poloxamer. The data obtained were tested normality with the Shapiro-Wilk test. Statistical analysis using Oneway ANOVA and Post-Hoc Tukey HSD to determine the significance of differences between groups for ALT parameter. Result show the use of ethanolic extract of red spinach leaves can reduce fatty liver condition based on decreased level of ALT and liver histopathologic. It is concluded that the ethanolic extract of red spinach leaves dose 400mg/kgBW rat combine with simvastatin can reduce activity of ALT until 31.57 U1-1

Inventarisasi Tumbuhan Kawasan Sempadan di situ Agathis, Universitas Indonesia, Depok, Jawa Barat

Situ Agathis adalah salah satu dari enam situ di Universitas Indonesia, Depok. Situ Agathis merupakan situ pertama yang menerima aliran air dari pemukiman warga. Ekosistemnya meliputi badan air dan sempadan yang telah rusak akibat pembuangan sampah dan limbah rumah tangga di sekitar Kawasan Beji, Depok. Namun terdapat beberapa spesies tumbuhan yang dapat bertahan hidup di sekitarnya. Oleh karena itu, dilakukan inventarisasi untuk mengetahui jenis-jenis tumbuhan yang dapat bertahan dalam wilayah tercemar situ. Studi dilakukan menggunakan metode line transect dengan tiga kali pengulangan pada tiap stasiun inlet, midlet, dan outlet. Hasil studi menunjukkan adanya 59 spesies yang berasal dari 51 genus dan 30 famili. Famili dengan jumlah spesies terbanyak adalah Asteraceae, Fabaceae, dan Malvaceae. Habitus yang banyak ditemukan adalah herba (47,46%), semak (6,78%), liana (3,39%), perdu (5,08%), dan pohon (37,29%). Jenis yang banyak ditemui merupakan spesies invasif, gulma, tanaman perintis, dan tanaman bioremediator yang toleran terhadap lingkungan tercemar

Effect of Curcumin and Honey to Pharmacokinetics of Paracetamol in Male Wistar Rats

Honey and curcumin is widely consumed by children as food supplements. Honey is useful as an antioxidant and antibacterial, while curcumin is useful as an antioxidant, antiinflammatory, antibacterial, antiviral. Both health supplements are not infrequently used in conjunction with drugs, especially paracetamol. This study aims to determine the effect of curcumin and honey on the pharmacokinetic parameters of paracetamol in male rats. In this study, test animals were divided into 3 groups: control, treatment I and treatment II. In the control group mice were given paracetamol 150mg / KgBW, treatment group I rats were given curcumin 18 mg / KgBW, 1 hour and then given paracetamol 150mg / KgBW whereas the treatment group II rats given a dose of honey 7.65 mL / KgBW along with giving paracetamol 150mg KgBB . The results showed that administration of curcumin on the pharmacokinetics of paracetamol in mice can decrease the primary parameters of the elimination phase of CLT for 68.25%, increasing the secondary parameter t 1 / 2 at 193.72%, thus increasing the derivative parameters AUC0-inf for 88.36%, and MRT of 155.17% (

Potential of Red Spinach Leaves (Amaranthus Tricolor L. ) Ethanolic Extract Standardized as Antihyperlipidemia: in Vivo Study Based on LDL (Low Density Lipoprotein) Parameter

This study aims to determine the potential for curative therapy ethanolic extract of red spinach leaves (Amaranthus tricolor L.) standardized to decrease LDL levels in vivo. Animal model used in this study were 30 male Wistar rats aged 2-3 months were randomly divided into 6 groups include normal control, negative control, positive control and three doses ratings eksktrak. Induction of hyperlipidemia using poloxamer on day 1st and propylthiouracil on day 5th to day 18th. The positive control groups were given by simvastatin and the treatment group were given three doses of the extract variations on each - each group ie 200 mg / kg, 400 mg / kg, and 800 mg / kg rat. Ethanolic extract of red spinach leaves that are used have been through a standardized test based on specific parameters and non-specific. Determination of plasma LDL levels was done 3 times, day 0 (baseline), day 4th (after induction process) and day 19th (after treatment). The results obtained show the ethanolic extract of red amaranth (Amaranthus tricolor L.) standardized at a dose of 800 mg / kg body weight can lower LDL levels statistically significant (p <0.05) compared with normal and negative group. It can be concluded that the ethanolic extract red spinach leaves standardized has activity as a curative therapy for hyperlipidemia