Efficacy of curcumin in the management of oral submucous fibrosis - An intervention study

Background and Objective: Oral submucous fibrosis (OSMF), a chronic, inflammatory, and potentially malignant disorder of the oral cavity, has been linked to the chewing of arecanuts. Antioxidants and quitting habits ought to both be incorporated into OSMF therapeutic interventions regimens. Current study aimed to determine curcumin's efficacy as an antioxidant in the management of OSMF. Materials and Methods: In this intervention study, 42 participants with OSMF were allocated into three groups. Group A received curcumin; group B received intralesional steroid injections; and group C received neither treatment (placebo group). For three months, groups A and B received twice-daily doses of 400 mg of curcumin each, while group C received twice-daily doses of placebo capsules. Group B also received biweekly intralesional steroid injections of 4 mg/ml of betamethasone. Data were analyzed using statistical tests. Results: After receiving interventions, group B patients showed clinically significant improvements in mouth opening. Both Group A and B reported a burning sensation reduction that was statistically significant. Statistically, greater improvement in mouth opening and a decrease in burning sensation were reported in group A. Conclusion: When employed as a combination therapy in the initial management of people with OSMF, curcumin can help patients with their clinical symptoms. Future research is recommended to use larger samples and longer treatment follow-up periods

Association of Scrub Typhus in Children with Acute Encephalitis Syndrome and Meningoencephalitis, Southern India.

Scrub typhus is an established cause of acute encephalitis syndrome (AES) in northern states of India. We systematically investigated 376 children with AES in southern India, using a stepwise diagnostic strategy for the causative agent of scrub typhus, Orientia tsutsugamushi, including IgM and PCR testing of blood and cerebrospinal fluid (CSF) to grade its association with AES. We diagnosed scrub typhus in 87 (23%) children; of those, association with AES was confirmed in 16 (18%) cases, probable in 55 (63%), and possible in 16 (18%). IgM detection in CSF had a sensitivity of 93% and specificity of 82% compared with PCR. Our findings suggest scrub typhus as an emerging common treatable cause of AES in children in southern India and highlight the importance of routine testing for scrub typhus in diagnostic algorithms. Our results also suggest the potential promise of IgM screening of CSF for diagnosis of AES resulting from scrub typhus