Compression and Relaxation of Fishing Effort in Response to Changes in Length of Fishing Season for Red Snapper (Lutjanus campechanus) in the Northern Gulf of Mexico

A standard method used by fisheries managers to decrease catch and effort is to shorten the length of a fishery; however, data on recreational angler response to this simple approach are surprisingly lacking. We assessed the effect of variable season length on daily fishing effort, measured by using numbers of boat launches per day, anglers per boat, and anglers per day from video observations, in the recreational sector of the federal fishery for red snapper (Lutjanus campechanus) in coastal Alabama. From 2012 through 2017, season length fluctuated from 3 to 40 d. Daily effort, measured by using mean number of boat launches per day (coefficient of multiple determination [R2]=0.58) and mean number of anglers per day (R2=0.67), increased linearly with season shortening, indicating effort compression. In 2017, 2 seasons were allowed: an early season (3 d) and an unanticipated late season (39 d). Daily effort decreased during the late season, indicating that effort can also be relaxed if anglers anticipate longer seasons. Model fit for mean number of anglers per day improved with the addition of a daily wind factor (R2=0.94). The results of this study indicate that responses of anglers to changing fishing seasons are dynamic

The market assessment of the announcements of corporate sell-offs

This study uses a two-beta market model to study the impact of announcements of voluntary corporate sell-offs for 144 firms

Petition for a Writ of Certiorari. Lawson v. FMR LLC, 134 S. Ct. 1158 (2014) (No. 12-3), 2012 U.S. S. Ct. Briefs LEXIS 2827

QUESTION PRESENTED Section 806 of the Sarbanes-Oxley Act, 18 U.S.C. § 1514A, forbids a publicly traded company, a mutual fund, or “any ... contractor [or] subcontractor ... of such company [to] ... discriminate against an employee in the terms and conditions of employment because of” certain protected activity. (Emphasis added). The First Circuit held that under section 1514A such contractors and subcontractors, if privately-held, may retaliate against their own employees, and are prohibited only from retaliating against employees of the public companies with which they work. The question presented is: Is an employee of a privately-held contractor or subcontractor of a public company protected from retaliation by section 1514A

The Impact of Wrongful Death Lawsuits on Police Officers

Law enforcement has become known as one of the most stressful occupations. Stress can have negative impacts on police officers’ professional careers and their personal life. This qualitative research revealed the unseen pressure of wrongful death lawsuits involving police officers, especially those cleared of any criminal wrongdoings. The study explored the police officers\u27 perceptions while gaining knowledge from their lived experiences of how wrongful death lawsuits impacted them professionally and personally. This qualitative study was guided by the person-in-environment theory, which means that the environment can affect the police officer. In return, the police officer can affect the environment. The methodology used was a qualitative research approach to obtain data from 10 participants from different police departments throughout South Carolina. The data were collected through in-person interviews consisting of 13 interview questions. Participants had to be current or retired police officers who had personally been involved in a wrongful death lawsuit. Each participant had to be justified in their actions that led to the civil case. Data were analyzed by using NVivo 12 qualitative data analysis software. Three major themes emerged, revealing that wrongful death lawsuits negatively impacted police officers professionally and personally. Results also showed the lack of support from police organizations and the lack of confidence in the legal system of civil liability. It is essential to improve police officers\u27 overall well-being for positive social change. The results could have a positive impact on police and community relations

Small scale cell culture based assay for predicting antibody reduction susceptibility

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Leveraging Sanofi intensified ICB platform to enable early process development for a labile and hard-to-express molecule

Within the biopharmaceutics industry, tremendous progress has been made in the implementation of early development antibody platforms to achieve high volumetric productivity and consistent product quality for novel therapies. More recently, development of new modalities provide opportunities for advancing exciting new therapeutic possibilities. However, many of these modalities present new upstream and downstream development challenges, e.g., low expression, labile molecules, low recovery, and unreliable product quality. The resulting additional development requirements increase the timelines for demonstrating Proof of Concept and may even prohibit certain therapeutic candidates from reaching the clinic at all. The Sanofi ICB platform provides opportunities to increase productivity and improve product quality, enabling manufacture of new entities previously inaccessible. Here, we present a case study of such a situation, in which the ICB platform is applied to an early-stage, labile, hard to express molecule produced from non-CHO mammalian cells. A combination of upstream and downstream high-throughput technologies have been incorporated to rapidly define a process sufficient for first-in-human studies. Process intensification enables adequate material generation within an acceptable number of batches for both development and clinical manufacturing. This case study demonstrates the strategy of using intensified perfusion platform for non-antibody modalities to support a diverse portfolio for our evolving industry

Increased Cortical Cerebral Blood Flow in Asymptomatic Human Immunodeficiency Virus-Infected Subjects

Human Immunodeficiency Virus (HIV) infected individuals are at high risk for ischemic stroke. To investigate the physiological basis for this risk, we used magnetic resonance imaging (MRI) to measure oxygen extraction fraction (OEF) and cerebral blood flow (CBF) in treatment naïve asymptomatic HIV-infected subjects and controls