Genetic variants and the metabolic syndrome: a systematic review

Several candidate gene studies on the metabolic syndrome (MetS) have been conducted. However, for most single nucleotide polymorphisms (SNPs) no systematic review on their association with MetS exists. A systematic electronic literature search was conducted until the 2nd of June 2010, using HuGE Navigator. English language articles were selected. Only genes of which at least one SNP–MetS association was studied in an accumulative total population =4000 subjects were included. Meta-analyses were conducted on SNPs with three or more studies available in a generally healthy population. In total 88 studies on 25 genes were reviewed. Additionally, for nine SNPs in seven genes (GNB3, PPARG, TCF7L2, APOA5, APOC3, APOE, CETP) a meta-analysis was conducted. The minor allele of rs9939609 (FTO), rs7903146 (TCF7L2), C56G (APOA5), T1131C (APOA5), C482T (APOC3), C455T (APOC3) and 174G>C (IL6) were more prevalent in subjects with MetS, whereas the minor allele of Taq-1B (CETP) was less prevalent in subjects with the MetS. After having systematically reviewed the most studied SNP–MetS associations, we found evidence for an association with the MetS for eight SNPs, mostly located in genes involved in lipid metabolis

What about the Women? Female Headship, Poverty and Vulnerability in Thailand and Vietnam

This paper investigates whether different types of female?headed households in Thailand and Vietnam are disadvantaged in terms of current consumption, exposure to shocks, consumption smoothing capacities, as well as vulnerability to poverty and downside risk. Using a unique panel data set of over 4000 rural households in both countries, we find that female headed households with an absent husband appear to be better off in terms of current consumption in both countries (suggesting a positive impact of remittances). However, de jure female headed households in Thailand and Vietnam are more exposed to shocks and are less able to insure their consumption against income shocks than other households. In line with this finding de jure female headed households are also more vulnerable to perceived downside risk. Instead, de facto female headed households are less vulnerable to poverty and not worse off in terms of vulnerability to perceived downside risk. --Poverty,Gender Analysis,Vulnerability to Poverty,Inter?generational Poverty

Vulnerability to Downside Risk and Poverty in Vietnam

In this paper we propose a new measure of vulnerability called vulnerability to downside risk. The relevant benchmark for this new measure is the current level of wellbeing of a household as opposed to another benchmark such as the poverty line. We argue that this measure adds complementary information to existing measures such as Calvo and Dercon's (2007) axiomatic measure of vulnerability to poverty. We apply a measure of both vulnerability to downside risk and to poverty to data from Vietnam. We show that consumption smoothing capacities and the probability to experience an adverse event differ substantially between different wealth groups. Consequently, the relation between initial wealth and vulnerability to downside risk is highly non-linear. While moderately but not extremely poor households are relatively vulnerable to extreme poverty, they are less vulnerable to downside risk than any other group of households

Melody generator: A device for algorithmic music construction

This article describes the development of an application for generating tonal melodies. The goal of the project is to ascertain our current understanding of tonal music by means of algorithmic music generation. The method followed consists of four stages: 1) selection of music-theoretical insights, 2) translation of these insights into a set of principles, 3) conversion of the principles into a computational model having the form of an algorithm for music generation, 4) testing the “music ” generated by the algorithm to evaluate the adequacy of the model. As an example, the method is implemented in Melody Generator, an algorithm for generating tonal melodies. The program has a structure suited for generating, displaying, playing and storing melodies, functions which are all accessible via a dedicated interface. The actual generation of melodies, is based in part on constraints imposed by the tonal context, i.e. by meter and key, the settings of which are controlled by means of parameters on the interface. For another part, it is based upon a set of construction principles including the notion of a hierarchical organization, and the idea that melodies consist of a skeleton that may be elaborated in various ways. After these aspects were implemented as specific sub-algorithms, the device produces simple but well-structured tonal melodies

Perceived Vulnerability to Downside Risk

In this paper we propose an approach to vulnerability called perceived vulnerability to downside risk. We argue that the other concepts of vulnerability, though partially adhering to the focus axiom, do not exclusively consider downside risks in their measures. The reason for this is that most of them use a pre-determined threshold such as the poverty line as their benchmark for analysis. Instead, we opt for the current level of wellbeing of a household as reference point. Also, we propose to use subjective risk perception as the source of information for quantifying vulnerability since it overcomes some of the shortcomings connected to the reliance on information about the past. Finally, we apply the measure of perceived vulnerability to downside risk to risk perception data from Thailand and Vietnam and find that households in the latter country tend to be more vulnerable than households in the former. Moreover, determinants of perceived vulnerability to downside risk differ significantly between the two countries

The U-shaped Investment Curve: Theory and Evidence

This paper examines how the investment of financially constrained firms varies with their level of internal funds. We develop a theoretical model of optimal investment under financial constraints. Our model endogenizes the costs of external funds and allows for negative levels of internal funds. We show that the resulting relationship between internal funds and investment is U-shaped. In particular, when a firm's internal funds are negative and sufficiently low, a further decrease leads to an increase in investment. This effect is driven by the investor's participation constraint: when part of any loan must be used to close a financing gap, the investor will provide funds only if the firm invests at a scale large enough to generate the revenue that enables the firm to repay. We test our theory using a data set with close to 100,000 firm-year observations. The data strongly support our predictions. Among other results, we find a negative relationship between measures of internal funds and investment for a substantial share of financially constrained firms. Our results also help to explain some contrasting findings in the empirical investment literature.Financial constraints, capital market imperfections, financial contracts, investment, internal funds, investment-cash flow sensitivity

Booms, Busts, and Fraud

We examine firm managers' incentives to commit fraud in a model where firms seek funding from investors and investors can monitor firms at a cost in order to get more precise information about firm prospects. We show that fraud incentives are highest when business conditions are good, but not too good: in exceptionally good times, even weaker firms can get funded without committing fraud, whereas in bad times investors are more vigilant and it is harder to commit fraud successfully. As investors' monitoring costs decrease, the region in which fraud occurs shifts towards better business conditions. It follows that if business conditions are sufficiently strong, a decrease in monitoring costs actually increases the prevalence of fraud. If investors can only observe current business conditions with noise, then the incidence of fraud will be highest when investors begin with positive expectations that are disappointed ex post. Finally, increased disclosure requirements can exacerbate fraud. Our results shed light on the incidence of fraud across the business cycle and across different sectors.Boom, Credit Cycle, Fraud, Monitoring

Detecting Extrasolar Planets with Integral Field Spectroscopy

Observations of extrasolar planets using Integral Field Spectroscopy (IFS), if coupled with an extreme Adaptive Optics system and analyzed with a Simultaneous Differential Imaging technique (SDI), are a powerful tool to detect and characterize extrasolar planets directly; they enhance the signal of the planet and, at the same time, reduces the impact of stellar light and consequently important noise sources like speckles. In order to verify the efficiency of such a technique, we developed a simulation code able to test the capabilities of this IFS-SDI technique for different kinds of planets and telescopes, modelling the atmospheric and instrumental noise sources. The first results obtained by the simulations show that many significant extrasolar planet detections are indeed possible using the present 8m-class telescopes within a few hours of exposure time. The procedure adopted to simulate IFS observations is presented here in detail, explaining in particular how we obtain estimates of the speckle noise, Adaptive Optics corrections, specific instrumental features, and how we test the efficiency of the SDI technique to increase the signal-to-noise ratio of the planet detection. The most important results achieved by simulations of various objects, from 1 M_J to brown dwarfs of 30 M_J, for observations with an 8 meter telescope, are then presented and discussed.Comment: 60 pages, 37 figures, accepted in PASP, 4 Tables adde