22 research outputs found
Capra cartilage-derived peptide delivery via carbon nano-dots for cartilage regeneration
Targeted delivery of site-specific therapeutic agents is an effective strategy for osteoarthritis treatment. The lack of blood vessels in cartilage makes it difficult to deliver therapeutic agents like peptides to the defect area. Therefore, nucleus-targeting zwitterionic carbon nano-dots (CDs) have immense potential as a delivery vehicle for effective peptide delivery to the cytoplasm as well as nucleus. In the present study, nucleus-targeting zwitterionic CDs have been synthesized as delivery vehicle for peptides while also working as nano-agents towards optical monitoring of cartilage healing. The functional groups of zwitterion CDs were introduced by a single-step microwave assisted oxidation procedure followed by COL II peptide conjugation derived from Capra auricular cartilage through NHS/EDC coupling. The peptide-conjugated CDs (PCDs) allows cytoplasmic uptake within a short period of time (âŒ30 m) followed by translocation to nucleus after âŒ24 h. Moreover, multicolor fluorescence of PCDs improves (blue, green, and read channel) its sensitivity as an optical code providing a compelling solution towards enhanced non-invasive tracking system with multifunctional properties. The PCDs-based delivery system developed in this study has exhibited superior ability to induce ex-vivo chondrogenic differentiation of ADMSCs as compared to bare CDs. For assessment of cartilage regeneration potential, pluronic F-127 based PCDs hydrogel was injected to rabbit auricular cartilage defects and potential healing was observed after 60 days. Therefore, the results confirm that PCDs could be an ideal alternate for multimodal therapeutic agents
MXene-Based Elastomer Mimetic Stretchable Sensors: Design, Properties, and Applications
Highlights MXenes, a new family of 2D nanomaterials, have been drawing notable attention due to their high electrical conductivity, processability, mechanical robustness and chemical tunability. Flexible sensors based on MXene-polymer composites are highly prospective for next-generation wearable electronics used in humanâmachine interfaces. With our article, we intend to fortify the bond between flexible matrices and MXenes thus promoting the swift advancement of flexible MXene-sensors for wearable technologies
Green Reduced Graphene Oxide Toughened Semi-IPN Monolith Hydrogel as Dual Responsive Drug Release System: Rheological, Physicomechanical, and Electrical Evaluations
Macroporous
hydrogel monoliths having tailor-made features, conductivity,
superstretchability, excellent biocompatibility, and biodegradability,
have become the most nurtured field of interest in soft biomaterials.
Green method assisted reduced graphene oxide has been inserted by
in situ free radical gelation into semi-IPN hydrogel matrix to fabricate
conducting hydrogel. Mechanical toughness has been implemented for
the grapheneâpolymer physisorption interactions with graphene
basal planes. Moreover, the as-prepared 3D scaffold type monolith
hydrogel has been rheologically superior regarding their high elastic
modulus and delayed gel rupturing. Îș-Carragenaan, one of the
components of the hydrogel, has biodegradable nature. The most significant
outcome is their low electrical percolation threshold and reversibly
ductile nature. Reversible ductility provides them with rubber-like
consistency in flow conditions. Surprising, the hydrogels showed dual
stimuli-responsiveness, that is, environmental pH and external electrical
stimulation. Electro-stimulation has been adopted here for the first
time in semi-IPN systems, which could be an ideal alternative for
iontopheretic devices and pulsatile drug release through skin. Regarding
this, the hydrogel also has been passed to biocompatibility assay;
they are noncytotoxic and show cell proliferation without negligible
cell death in liveâdead assay. The porosity of the nanocomposite
scaffold-like gels was also analyzed by microcomputed tomography (Ό-CT),
which exhibited their connectivity in cell/voids inside the matrix.
Thus, the experimentations are on the support of biocompatible soft
material for dual-responsive tunable drug delivery
Naturally Derived Carbon Dots In Situ Confined Self-Healing and Breathable Hydrogel Monolith for Anomalous Diffusion-Driven Phytomedicine Release
Fluorescent nanocarbons are well-proficient nanomaterials
because
of their optical properties and surface engineering. Herein, Apium graveolens-derived carbon dots (ACDs) have
been synthesized by a one-step hydrothermal process without using
any surplus vigorous chemicals or ligands. ACDs were captured via
an in situ gelation reaction to form a semi-interpenetrating polymer
network system showing mechanical robustness, fluorescent behavior,
and natural adhesivity. ACDs-reinforced hydrogels were tested against
robust uniaxial stress, repeated mechanical stretching, thixotropy,
low creep, and fast strain recovery, confirming their elastomeric
sustainability. Moreover, the room-temperature self-healing behavior
was observed for the ACDs-reinforced hydrogels, with a healing efficacy
of more than 45%. Water imbibition through hydrogel surfaces was digitally
monitored via âbreathingâ and âaccelerated breathingâ
behaviors. The phytomedicine release from the hydrogels was tuned
by the ACDsâ microstructure regulatory activity, resulting
in better control of the diffusion rate compared to conventional chemical
hydrogels. Finally, the phytomedicine-loaded hydrogels were found
to be excellent bactericidal materials eradicating more than 85% of
Gram-positive and -negative bacteria. The delayed network rupturing,
superstretchability, fluorescent self-healing, controlled release,
and antibacterial behavior could make this material an excellent alternative
to soft biomaterials and soft robotics
Naturally Derived Carbon Dots In Situ Confined Self-Healing and Breathable Hydrogel Monolith for Anomalous Diffusion-Driven Phytomedicine Release
Fluorescent nanocarbons are well-proficient nanomaterials
because
of their optical properties and surface engineering. Herein, Apium graveolens-derived carbon dots (ACDs) have
been synthesized by a one-step hydrothermal process without using
any surplus vigorous chemicals or ligands. ACDs were captured via
an in situ gelation reaction to form a semi-interpenetrating polymer
network system showing mechanical robustness, fluorescent behavior,
and natural adhesivity. ACDs-reinforced hydrogels were tested against
robust uniaxial stress, repeated mechanical stretching, thixotropy,
low creep, and fast strain recovery, confirming their elastomeric
sustainability. Moreover, the room-temperature self-healing behavior
was observed for the ACDs-reinforced hydrogels, with a healing efficacy
of more than 45%. Water imbibition through hydrogel surfaces was digitally
monitored via âbreathingâ and âaccelerated breathingâ
behaviors. The phytomedicine release from the hydrogels was tuned
by the ACDsâ microstructure regulatory activity, resulting
in better control of the diffusion rate compared to conventional chemical
hydrogels. Finally, the phytomedicine-loaded hydrogels were found
to be excellent bactericidal materials eradicating more than 85% of
Gram-positive and -negative bacteria. The delayed network rupturing,
superstretchability, fluorescent self-healing, controlled release,
and antibacterial behavior could make this material an excellent alternative
to soft biomaterials and soft robotics
Naturally Derived Carbon Dots In Situ Confined Self-Healing and Breathable Hydrogel Monolith for Anomalous Diffusion-Driven Phytomedicine Release
Fluorescent nanocarbons are well-proficient nanomaterials
because
of their optical properties and surface engineering. Herein, Apium graveolens-derived carbon dots (ACDs) have
been synthesized by a one-step hydrothermal process without using
any surplus vigorous chemicals or ligands. ACDs were captured via
an in situ gelation reaction to form a semi-interpenetrating polymer
network system showing mechanical robustness, fluorescent behavior,
and natural adhesivity. ACDs-reinforced hydrogels were tested against
robust uniaxial stress, repeated mechanical stretching, thixotropy,
low creep, and fast strain recovery, confirming their elastomeric
sustainability. Moreover, the room-temperature self-healing behavior
was observed for the ACDs-reinforced hydrogels, with a healing efficacy
of more than 45%. Water imbibition through hydrogel surfaces was digitally
monitored via âbreathingâ and âaccelerated breathingâ
behaviors. The phytomedicine release from the hydrogels was tuned
by the ACDsâ microstructure regulatory activity, resulting
in better control of the diffusion rate compared to conventional chemical
hydrogels. Finally, the phytomedicine-loaded hydrogels were found
to be excellent bactericidal materials eradicating more than 85% of
Gram-positive and -negative bacteria. The delayed network rupturing,
superstretchability, fluorescent self-healing, controlled release,
and antibacterial behavior could make this material an excellent alternative
to soft biomaterials and soft robotics
Naturally Derived Carbon Dots In Situ Confined Self-Healing and Breathable Hydrogel Monolith for Anomalous Diffusion-Driven Phytomedicine Release
Fluorescent nanocarbons are well-proficient nanomaterials
because
of their optical properties and surface engineering. Herein, Apium graveolens-derived carbon dots (ACDs) have
been synthesized by a one-step hydrothermal process without using
any surplus vigorous chemicals or ligands. ACDs were captured via
an in situ gelation reaction to form a semi-interpenetrating polymer
network system showing mechanical robustness, fluorescent behavior,
and natural adhesivity. ACDs-reinforced hydrogels were tested against
robust uniaxial stress, repeated mechanical stretching, thixotropy,
low creep, and fast strain recovery, confirming their elastomeric
sustainability. Moreover, the room-temperature self-healing behavior
was observed for the ACDs-reinforced hydrogels, with a healing efficacy
of more than 45%. Water imbibition through hydrogel surfaces was digitally
monitored via âbreathingâ and âaccelerated breathingâ
behaviors. The phytomedicine release from the hydrogels was tuned
by the ACDsâ microstructure regulatory activity, resulting
in better control of the diffusion rate compared to conventional chemical
hydrogels. Finally, the phytomedicine-loaded hydrogels were found
to be excellent bactericidal materials eradicating more than 85% of
Gram-positive and -negative bacteria. The delayed network rupturing,
superstretchability, fluorescent self-healing, controlled release,
and antibacterial behavior could make this material an excellent alternative
to soft biomaterials and soft robotics
Naturally Derived Carbon Dots In Situ Confined Self-Healing and Breathable Hydrogel Monolith for Anomalous Diffusion-Driven Phytomedicine Release
Fluorescent nanocarbons are well-proficient nanomaterials
because
of their optical properties and surface engineering. Herein, Apium graveolens-derived carbon dots (ACDs) have
been synthesized by a one-step hydrothermal process without using
any surplus vigorous chemicals or ligands. ACDs were captured via
an in situ gelation reaction to form a semi-interpenetrating polymer
network system showing mechanical robustness, fluorescent behavior,
and natural adhesivity. ACDs-reinforced hydrogels were tested against
robust uniaxial stress, repeated mechanical stretching, thixotropy,
low creep, and fast strain recovery, confirming their elastomeric
sustainability. Moreover, the room-temperature self-healing behavior
was observed for the ACDs-reinforced hydrogels, with a healing efficacy
of more than 45%. Water imbibition through hydrogel surfaces was digitally
monitored via âbreathingâ and âaccelerated breathingâ
behaviors. The phytomedicine release from the hydrogels was tuned
by the ACDsâ microstructure regulatory activity, resulting
in better control of the diffusion rate compared to conventional chemical
hydrogels. Finally, the phytomedicine-loaded hydrogels were found
to be excellent bactericidal materials eradicating more than 85% of
Gram-positive and -negative bacteria. The delayed network rupturing,
superstretchability, fluorescent self-healing, controlled release,
and antibacterial behavior could make this material an excellent alternative
to soft biomaterials and soft robotics