5 research outputs found
Uterine mast cell tumor: a clinical and cytohistopathological study
Background: Mast cells are one of the characteristic factors in angiogenesis, growth, and metastatic spread of tumors. Further studies are suggested to determine the type of these cells which might be useful in the assessment of biological nature of the tumor and its future treatment modality. Few studies have evaluated mast cell infiltration in visceral tumors, especially uterine tumors. Case presentation: In this study, age, sex, death rate, and histologic patterns were in agreement with those of previous reports on canine mast cell tumors. Cytopathology assays are widely used to prognosticate canine uterine mast cell tumors (MCT). There is limited information about these prognostic assays used on MCT that arise in the uterine. The anisocytosis and anisocytosis and giant cells were present in the tumor. Furthermore, the tumor had nuclear atypia with scattered multinucleated cells and prominent nucleoli and tumor were classified as poorly granulated. Under microscopic examination, we observed diffuse infiltration and proliferation of tumor cells from the uterine different area and the infiltrative characteristics and distribution patterns of neoplastic cells were observed. This tumor consisted of sheets and cords of uniform round cells with discrete cytoplasmic margins. Microscopically, the neoplastic masses were poorly-demarcated and lacked capsules and tumor cell usually showed a distinct cell boundary. Nevertheless, the neoplastic cells were located between collagen bundles forming small clusters and sheets and had large, centrally located, round to ovoid nuclei. In addition, eosinophils were scattered among the mast cells at the periphery of the masses. The presence of eosinophils and the observation, at high magnification, of cells with cytoplasmic metachromatic granules. Conclusion: Based on these findings, a diagnosis of poorly-differentiated mast cell tumor was made and data histologic grading was available for tumor. Neoplasm was poorly differentiated or gradeIII
RETRACTION: Diagnostic investigations of canine prostatitis incidence together with benign prostate hyperplasia, prostate malignancies, and biochemical recurrence in high-risk prostate cancer as a model for human study (Retraction of Vol 36, Pg 2437, 2015)
The aim of this study was to evaluate the prevalence of acute and chronic inflammation, benign prostatic hyperplasia (BPH), and cancer of the prostate glands in the canine as a human model in prostate disorders. The study was carried out on 12 cases of different male dogs of terrier (50 ), German shepherd (25 ) breeds, and Greden (25 ), and the age of the dogs ranged from 6 to 13 years (average age 7.8 +/- 3.6). The bodyweight ranged from 3.6 to 7.9 kg. Signalment, clinical signs, and diagnostic tools such as ultrasonography, urinary cytology, and histopathology are presented. Dysuria was the most common clinical sign in this study and occurred in 10/12 canine (83.3 ) included. Other clinical signs included lameness (5/12 canine, 41.6 ) and constipation (3/12 canine, 25 ). The range of duration of clinical signs was 5 days to 7 months. Moreover, in the present study, the urinary biochemical markers of different prostate lesions include blood, protein, and glucose and were detected in 11/12 cases (91.6 ), 5/12 cases (41.6 ), and 2/12 cases (16.6 ), respectively. Taken together, sonographic data were classified into four groups based on histological diagnosis. In 7/12 cases (58.4 ), the prostate appeared to have BPH lesions, and the remaining lesions included inflammation (3/12 cases, 25 ), abscess (1 case, 8.3 ), and adenocarcinoma (1 case, 8/3 ) on ultrasound. In all cases, prostate tissue had an irregular echotexture. None of the dogs had sonographic evidence of sublumbar lymph node enlargement. Histopathologically, we looked at the prevalence of inflammation (33.3 chronic and 8.3 acute) and BPH (58.4 ) in dogs of different ages and breeds, and also, we observed chronic inflammation in >20 of dogs, which was about 25 in 3 cases of the 12 cases referred. More chronic inflammation was associated with more BPH. The majority of the asymptomatic inflammation that is detected in the prostate is classified as chronic inflammation (i.e., as evidenced by the presence of monocytic and/or lymphoplasmacytic inflammatory cell infiltrates); however, acute inflammation is also observed to a lesser degree. Acute inflammation, as is typically evidenced by the infiltration of neutrophils, is classically an indicator of an infectious process. Finally, the patients included seven castrated, four castrated together with antibiotic therapy, and one castrated together with chemotherapy intact male dogs, which were treated with the mentioned cases. In conclusion, chronic prostatic inflammation could be a central mechanism in BPH progression, but the pathological features of tissue inflammation were different between BPH and prostate cancer (PCa). Nevertheless, the histological examination of prostate biopsies remains the only way to diagnose prostatic disorders
Retraction Note to: Diagnostic investigations of canine prostatitis incidence together with benign prostate hyperplasia, prostate malignancies, and biochemical recurrence in high-risk prostate cancer as a model for human study (Tumor Biol, (2015), 36, (2437-2445), 10.1007/s13277-014-2854-4)
This article has been retracted at the request of the Editor-in- Chief, the International Society of Oncology and BioMarkers (ISOBM) and the Publisher per the Committee on Publication Ethics guidelines. The article shows evidence of irregularities in authorship during the submission process, there is strong reason to believe that the peer review process was compromised and the article contains patchwork plagiarism from a variety of sources. The main sources are (amongst others): Bruce E. LeRoya, icole Northrup, Prostate cancer in dogs: Comparative and clinical aspects. The Veterinary Journal. 2009; 180:2 149-162 DOI: 10.1016/j.tvjl.2008.07.012 J. Smith, Canine prostatic disease: A review of anatomy, pathology, diagnosis, and treatment, Proceedings of the Annual Conference of the Society for Theriogenology. The Society for Theriogenology 2008 Annual Conference, Theriogenology. 2008; 70:3 375-383 DOI: 10.1016/ j.theriogenology.2008.04.039. © 2016, International Society of Oncology and BioMarkers (ISOBM)