The Conceptual Model of Content Marketing in the New Media Technology and Identifying Effective Factors in Iran

The aim of this study is to determine the influential factors in content marketing in media new technology and to Model a conceptual frame for the current situation of Iran. To determine these factors, the Specialist councils consisting of 21 members including 7 university professors, 7 people dealing in production, dissimilation and distribution and 7 directors of companies and Organizations were selected on purpose. The primary agents including 40 ones were selected through direct interview with specialists and the review of other professors’ interviews and the survey of texts and articles. This reveals 80% correlation in the opinion evaluation provided by Viber and the data based on Delphi procedure. Twelve influential factors in content Marketing were recognized in Iran and a conceptual model was planned. They are as follows: Content strengthens, frame proportion, proper volume, impressive design, work quality, Novel subject, coordination with customers’ needs, interests and tastes, and the Manufacturers’ skills, coordination with earlier contents, their costs and values and duration. The model tends to function as a guide for manufacturers to promote faith and to persuade Shopping among customers. Its implication for further research is to weigh these factors

Coping Strategies for chronic stress and Personality Characteristics with interaction of Job burnout

Job burnout is a syndrome that emergences as a response to chronic stress and mostly in human professional services. Among the main factors that affect on the job burnout, are personality characteristics and coping strategies to stress. In this regard, this study examines the role of personality characteristics and coping strategies in Tabriz Saderat Bank's staffs. In this correlation research, 242 Saderat Bank's Staffs selected in the form of cluster sampling and administered by Demographic Questionnaire, Maslash Burnout Scale, NEO- Five Factor Personality Inventory and Lazarus & Folkman Coping Styles Questionnaire. Data were analyzed by descriptive analysis methods and multiple regressions (simultaneous).The findings indicated that the most of Bank's staffs (%52/3) have moderate burnout. Neuroticism personality factor and emotional-focused coping strategy are positive predictors but extroversion and conscientiousness are negative predictors of Bank staff's job burnout. In sum, present study provided support to previous findings that there was significant relation between job burnout and personality characteristics

Epidemiological Survey of Sinonasal Malignancy in North-East Iran

Introduction: Sinonasal malignancies are uncommon neoplasms with several histological subtypes. These malignancies have a poor prognosis and, because of the nonspecific nature of the symptoms, most patients are diagnosed late when the disease is already at an advanced stage. Therefore, most sinonasal malignancies tend to be treated with surgery and postoperative radiotherapy. Understanding the incidence and prevalence of clinical symptoms, pathology, diagnosis, and subsequent prognosis of the disease is important for early diagnosis.   Materials and Methods: Medical records of patients with a confirmed diagnosis of sinonasal malignancy in a tertiary referral center from 1998 to 2009 were retrospectively investigated by chronological examination. Information relating to symptoms, pathology, and treatment of patients were collected from the checklists and used to generate tables and graphs, while descriptive statistical tests were used to compare data.   Results: The records of 69 patients were examined, including 45 (65.2%) male and 24 (34.8%) female patients with a combined mean age of 54.07±16.04 years. Twenty-one patients (30.4%) were aged less than 45 years and 48 (69.6%) were more than 45 years of age. The most common symptom was facial swelling in 46 (66.6%) patients and the most common kind of tumor was squamous cell carcinoma in 28 (40.6%) patients. The primary location of the tumor in most patients was the maxillary sinus (54 patients; 78.3%). A majority of patients present in advanced stage (stage III or more) with intraorbital (39.1%) or intracranial (4.3%) involvement, or regional lymphatic (28.99%) or distance metastasis (7.2%). The most common treatment was surgery (17 patients; 24.6%).   Conclusion:  Due to their nonspecific symptoms, most sinonasal malignancies are diagnosed at an advanced stage of the disease. Therefore, all patients with nonspecific symptoms, especially older males, should be evaluated for sinonasal malignancies in order to eliminate this diagnosis

Mitochondrial complex i gene variations; As a potential genetic risk factor in pathogenesis of multiple sclerosis

© 2014 Elsevier B.V. Background and purpose:Multiple sclerosis (MS) is an autoimmune-mediated inflammatory and debilitating disease of the central nervous system. Several investigations have suggested that the mitochondrial DNA encoded subunits of complex I gene variations are involved in the progression of MS. In this study, we investigated the possible association between mitochondrial complex I gene variations and MS in a Filipino population. Material and methods: A total of 300 individuals were included in the present study, two-hundred patients with MSclinical symptoms, and one-hundred healthy subjectswithoutMS clinical features.Weamplified target genes of mtDNA using polymerase chain reaction technique (PCR), and sequenced these to evaluate mitochondrial complex I gene variations. Results:We found nine variations (Nt 4216 T N C, Nt 5153 A N G, Nt 10142 C N T, Nt 11353 T N C, Nt 11935 T N C, Nt 12062 C N T, Nt 13042 G N A, Nt 13708 G N A and Nt 14179 G N A) in mtDNA-encoded complex I subunit genes. Our results showed that the prevalence of ND1, ND2, ND3, ND4 and ND5 gene variationswas significantly higher in patients than in healthy controls (P b 0.0001).Whereas, the frequency of Nt 14179 G N A variation inND6 gene was significantly higher in the control group compared with the patients (P b 0.0001). Conclusion: Taken together our data supports a strongly positive association between mitochondrial complex I gene variations and MS pathogenesis in a Filipino population

Cerebral Sinus Thrombosis in Scleroderma: A Case Report

Scleroderma or systemic sclerosis is a multisystem disease due to excessive collagen deposition in different organs and autoimmunity by production of autoantibodies.According to previous reports, brain is rarely affected in scleroderma, howeverrecent studies show central nervous system can be affect not only as a complication of systemic involvement (hypertension, renal failure) but also as a primary manifestation.In scleroderma, thrombus formation in central nervous system and peripheral systems is uncommonmay be due to endothelial cells damage which causes to release antithrombotic factors. We discuss a scleroderma patient with high titter of anticardiolipin antibody who developed to cerebral sinus thrombosis and cerebellum infarction. Then we review literature for both primary brain involvement and thrombotic event in systemic sclerosis

Investigation of Exportin 5 (XPO5) mRNA expression in breast cancer patients

Background and objectives: Deregulation in the expression of microRNAs is involved in the pathogenesis of various malignancies. Impaired microRNAs processing pathway is one possible mechanism for global deregulation of the miRNAs. Exportin 5 (XPO5) is a key member of this pathway that links nuclear and cytoplasmic steps of miRNAs biogenesis together. XPO5 deregulation has been reported in some cancers but very little is known about its role in breast cancer. Therefore, this study aimed to evaluate the mRNA expression of XPO5 in breast cancer in an Iranian population. Methods: In this case-control study, 30 tumoral tissues and 30 tumor-free margins were collected from breast cancer patients. After RNA extraction and cDNA synthesis, XPO5 mRNA expression level was assessed using quantitative Real-Time PCR. Results: Our results showed that XPO5 was overexpressed in 53.3% of tumoral tissues but the difference in the gene expression level between tumoral tissues and tumor-free margins was not statistically significant (P-value=0.834). XPO5 expression level showed no statistically significant correlation and association with clinical and pathological parameters. Conclusion: Overexpression of XPO5 in large percent of patients indicates that high level of XPO5 expression may be a tumorigenic factor for breast cancer which needs to be investigated more deeply

The Role of Carpet Hand-weaving Cooperatives of Zanjan Province on Increasing the Exports of Hand-woven Carpets

Hand-woven Persian carpet as an art and a craft has been long precedent in Iran’s history. Despite of this historical record, there are numerous problems with adapting this valuable hand-woven product with modern international markets to achieve its true position. Therefore this study with the objective of examining the role of carpet hand-weaving cooperatives in developing the exports of this carpet was conducted in 2010. The statistical population was the managers of carpet hand-weaving cooperative companies of Zanjan Province, experts in Zanjan Department of Commerce, experts in the General Department of Cooperation in Zanjan, traders and exporters of Zanjan, and the  necessary data was collected from the sample (selected with random sampling method) through 25 questionnaires. The results of the study show that, although carpet hand-weaving cooperatives have improved their role in exports through governmental supports, however because education courses were not export oriented, the cooperatives could not utilized this tool to improve their role in increasing the exports of hand-woven carpets. Also most of carpet hand-weaving cooperatives could not completely identify target market to attend international exhibitions and therefore increase their role in development of hand-woven carpets of the country

Magnetic Graphene Quantum Dot/Chitosan Bionanocomposite Hydrogel Beads for Drug Delivery System: Synthesis and Application

Hypothesis: In recent years, scientists and researchers have been looking for new and advanced materials for use in various fields, including drug delivery and biotechnology. One of the attractive  materials that has been considered in this field is chitosan-based bionanocomposite hydrogel beads. Chitosan-based bionanocomposite hydrogel beads have attracted attention as carriers in drug delivery systems due to their inherent properties such as excellent biocompatibility, high swelling, and high storage capacities.Methods: First graphene quantum dots (GQDs) were prepared by the pyrolysis method, and then their magnetic properties were obtained using iron nanoparticles (MGQD). Next they were coated with chitosan hydrogel (CS-MGQD) and finally loaded with methotrexate (MTX/CS-MGQD). This unique combination of the properties of chitosan hydrogel, the magnetic properties of graphene quantum dots, and the ability to adjust drug release has been able to create an important milestone in the field of drug delivery research and the compatibility of drugs with the biological environment. Through various analyses, including FTIR to analyze the spectra of the functional groups, XRD to identify the crystal structure, and SEM to examine the morphology of the samples, the success of the synthesis and formation of the desired compound was confirmed.Findings: The fabricated CS and CS-MGQD hydrogel beads were loaded with about 84% and 64% MTX, respectively. The results of the swelling behavior and drug release behavior showed that the hydrogel beads experience pH-dependent swelling and release of MTX. In addition, investigating the effect of MGQD concentration on swelling behavior and drug release showed that CS-MGQD has favorable stability and controllable drug release in an acid environment. Also, the Weibull kinetic model was found to be the best-fitting model for the release of MTX from CS-MGQD at pH 5. These findings suggest that the prepared magnetic bionanocomposite hydrogel beads have a good potential for pH-sensitive implantable drug delivery in the treatment of cancerous tissue

The expression of Drosha, DGCR8, Dicer and Ago-2 genes are upregulated in human umbilical vein endothelial cells under hyperglycemic condition

Objectives. It has been shown that dysregulation of miRNAs expression contributes to the pathogenesis and progression of the diabetes and diabetes-related complications. Drosha, DGCR8, Dicer, and Ago-2 are involved in the miRNA maturation. The aim of the present study was to investigate the mRNA expression levels of these genes in the human umbilical vein endothelial cells (HUVECs) under hyperglycemic condition