Evaluation of Matrix Metalloproteinase 2 and 9 Activity in Patients with Prostate Cancer and Benign Prostate Hyperplasia Compared with Healthy Individuals

Background and Aim: Prostate cancer (PC) is one of the most prevalent cancers with high mortality and morbidity in men, which can be treated in different ways before the progression and metastasis to distant organs. Destruction of extracellular matrix by matrix metalloproteinase (MMP), particularly by the 2 and 9 subtypes, has an important role in the metastasis of PC. We aimed to assess the activity of MMP 2 and 9 and some related metalloproteinases in PC and with benign prostate hyperplasia (BPH) patients in comparison to healthy individuals. Methods: In this case-control study, 72 individuals referred to Imam Khomeini hospital (Tehran, Iran), have been divided into 3 groups, including PC, BPH, and healthy control. Age and body mass index (BMI) for all groups have been matched. Venous blood samples were used to assess the enzyme activity by the zymography technique. Results: The activity of MMP-2 and 9 was significantly higher in PC than BPH and control groups. But there was no difference in the activity of enzymes in patients with PC according to the Gleason score. Conclusion: The results suggested that MMPs activity can be considered a diagnostic marker for PC. However, further studies are required to establish this concept. *Corresponding Author: Abbas Khonakdar-Tarsi; Email: [email protected] Please cite this article as: Shojaee M, Mohammadi P, Jafarpour H, Pouriamehr S, Barmaki H, Khonakdar-Tarsi A. Evaluation of Matrix Metalloproteinase 2 and 9 Activity in Patients with Prostate Cancer and Benign Prostate Hyperplasia Compared with Healthy Individuals. Arch Med Lab Sci. 2020;6:1-6(e12). https://doi.org/10.22037/amls.v6.3237

Nutrition Counseling Position in Reducing the Duration of Admission for Patients with Type 2 Diabetes Undergoing Cataract Surgery

Background and Aim: Cataract is one of the most common ocular diseases caused by various causes including congenital, resulting from trauma, drug or radiation, diabetes, or aging. Diabetes type 2, as a common metabolic disorder, is one of the main reasons for cataracts. we aimed to study nutritional counseling's status on the correction of glucose and urea and creatinine patterns and blood pressure of patients undergoing cataract surgery and reducing the pre-operative hospitalization time. Methods: In this study, 60 women with type 2 diabetes and 39 male participants aged 25 to 65 (aged 25 to 65) were randomly assigned into two groups (control without diet and nutritional counseling). The target group (presentation of diabetic diet and nutrition counseling) went under investigation two weeks before cataract surgery. Blood sampling proceeded from the arm vein in a sitting way one day before and after the diet (12 hours of fasting). Results: Fasting blood glucose, body weight, waist circumference, urea, creatinine, blood pressure, and hospitalization period were significantly decreased after surgery (p≤0.05). Conclusion: The results showed that receiving nutrition counseling and diet before cataract surgery can improve fasting blood glucose, 2-hour blood glucose, body weight, urea, creatinine, blood pressure, and thus hospitalization and recovery be reduced after surgery. *Corresponding Author: Fariba Mohammadi Tahroodi; Email: [email protected] Please cite this article as: Vaziri Javid R, Safizadeh F, Lotfi F, Pouriamehr S, Khonakdar-Tarsi A, Akbari Javar A, Zarpou S, Mohammadi Tahroodi F. Nutrition Counseling Position in Reducing the Duration of Admission for Patients with Type 2 Diabetes Undergoing Cataract Surgery. Arch Med Lab Sci. 2019;5(4): 37-43. https://doi.org/10.22037/amls.v5i4.3008