Psychological and Psychophysiological Effects of Recuperative Music Postexercise

Purpose: Few studies have examined the psychological and psychophysiological effects of recuperative music after exhaustive exercise. The main purpose of the present study was to examine the effects of two music conditions compared with a no-music control on psychological and psychophysiological recovery processes after exercise. Methods: A randomized, fully counterbalanced, crossover design was used. Core affect, salivary cortisol, heart rate, and blood pressure were measured before exhaustive exercise, immediately after, and in 10-, 20-, and 30-min intervals during passive recovery (21 women and 21 men; 20.9 T 1.7 yr) over three separate trials (slow, sedative music; fast, stimulative music; no-music control). The exercise task entailed incremental cycle ergometry performed at 75 rpm with an increase in intensity of 22.5 WIminj1 at the end of each minute until exhaustion. Data were analyzed using mixed-model 3 (condition) 4 (time) 2 (gender) MANOVA/ANCOVA. Results: The largest decline in affective arousal between active and passive recovery phases was evident in the slow, sedative condition (Gp 2 = 0.50). Women had a more pronounced reduction in arousal than did men in the slow, sedative music condition. Heart rate measures showed that fast, stimulative music inhibited the return of heart rate toward resting levels (Gp 2 = 0.06). Similarly, salivary cortisol levels tended to be lower in response to slow, sedative music (Gp 2 = 0.11). There was a main effect of condition for affective valence indicating that the slow, sedative condition elicited more positive affective responses compared with the control and fast, stimulative conditions (Gp 2 = 0.12). Conclusions: The present findings support the notion that slow, sedative music can expedite the recovery process immediately after strenuous exercise. Key Words: AFFECT, CORTISOL, ENTRAINMENT, RECOVERY, PSYCHOBIOLOGY, SEDATIO

Pentastatin-1, a collagen IV derived 20-mer peptide, suppresses tumor growth in a small cell lung cancer xenograft model

<p>Abstract</p> <p>Background</p> <p>Angiogenesis is the formation of neovasculature from a pre-existing vascular network. Progression of solid tumors including lung cancer is angiogenesis-dependent. We previously introduced a bioinformatics-based methodology to identify endogenous anti-angiogenic peptide sequences, and validated these predictions <it>in vitro </it>in human umbilical vein endothelial cell (HUVEC) proliferation and migration assays.</p> <p>Methods</p> <p>One family of peptides with high activity is derived from the α-fibrils of type IV collagen. Based on the results from the <it>in vitro </it>screening, we have evaluated the ability of a 20 amino acid peptide derived from the α5 fibril of type IV collagen, pentastatin-1, to suppress vessel growth in an angioreactor-based directed <it>in vivo </it>angiogenesis assay (DIVAA). In addition, pentastatin-1 suppressed tumor growth with intraperitoneal peptide administration in a small cell lung cancer (SCLC) xenograft model in nude mice using the NCI-H82 human cancer cell line.</p> <p>Results</p> <p>Pentastatin-1 decreased the invasion of vessels into angioreactors <it>in vivo </it>in a dose dependent manner. The peptide also decreased the rate of tumor growth and microvascular density <it>in vivo </it>in a small cell lung cancer xenograft model.</p> <p>Conclusions</p> <p>The peptide treatment significantly decreased the invasion of microvessels in angioreactors and the rate of tumor growth in the xenograft model, indicating potential treatment for angiogenesis-dependent disease, and for translational development as a therapeutic agent for lung cancer.</p

Tumour necrosis factor and PI3-kinase control oestrogen receptor alpha protein level and its transrepression function

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2410160

Prime Movers: Effects of Subliminal Primes, Music, and Music Video on Psychological Responses to Exercise

This is a pre-copyedited, author-produced version of an article accepted for publication in Annals of Behavioral Medicine following peer review. The version of record Suzanne T Pottratz, PhD, Jasmin C Hutchinson, PhD, Costas I Karageorghis, PhD, Elizabeth M Mullin, PhD, Zachary Zenko, PhD, Prime Movers: Effects of Subliminal Primes, Music, and Music Video on Psychological Responses to Exercise, Annals of Behavioral Medicine, , kaaa036 is available online at: https://academic.oup.com/abm/advance-article/doi/10.1093/abm/kaaa036/5850835#204363209 and https://doi.org/10.1093/abm/kaaa03