29 research outputs found
Impact of salvage treatment on initial relapses in patients with Hodgkin disease, stages I-III
Management of Non-Hodgkinâs Lymphomas: Conclusions of the Third Intercity Meeting, 1988
Ninety-one Cases of Breast Cancer and Chronic Lymphoproliferative Neoplasm: A Retrospective Review of a Population at High Risk for Multiple Malignancies
Hematological Evaluation of Primary Extra Nodal Versus Nodal NHL: A Study from North India
Primary extra nodal lymphomas (EN-NHL) are different from primary nodal non-Hodgkinâs lymphoma (N-NHL) and are comparatively less common. Hemogram findings and bone marrow involvement is less studied and very few reports are available in the literature. The present study is a retrospective analysis of bone marrow samples evaluated for staging of non-Hodgkinâs lymphoma. The age, sex distribution, clinical features, and site of presentation, hemogram findings, pattern of bone marrow involvement and grade of reticulin fibrosis was noted. These findings were compared with the type of non-Hodgkinâs lymphoma and prognostic information was determined. A total of 647 cases of NHL, which underwent bone marrow examination for staging, over a seven year period, were retrieved and analyzed for all hematological parameters. Prevalence of EN-NHL was 23.5% (152/647), while nodal NHL comprised 76.5% (495/647) of all NHL cases. 90.1% (137/152) cases of EN-NHL were adult patients, out of which 15.3% (21/137) cases showed bone marrow infiltration as compared to 89% (441/495) adult primary nodal NHL cases, of which 39% (175/441) showed bone marrow infiltration. 9.9% (15/152) cases of EN-NHL were pediatric patients, out of which 40% (6/15) showed bone marrow infiltration, while 10.9% (54/495) of nodal NHL cases were pediatric, of which 20.3% (11/54) showed bone marrow infiltration. Hemogram findings were not found useful in predicting bone marrow infiltration in both nodal as well as EN-NHL. 100% (6/6) of pediatric patients had high grade lymphoma as compared to 48% (9/21) of adult patients, showing bone marrow infiltration in EN-NHL group. Reticulin fibrosis also did not reveal relation with grading of NHL. Prognostically EN-NHL of stomach and central nervous system were found to be better than EN-NHL of other sites, as none of these cases showed bone marrow infiltration. EN-NHL can involve various sites and the prognosis depends upon the sites of disease as well as the type of NHL. Moreover, pediatric EN-NHL cases are likely to have poorer prognosis, due to increased risk of bone marrow involvement as compared to their counterparts having primary nodal NHL. Bone marrow infiltration at times cannot be assessed reliably from hemogram findings only and a bone marrow biopsy for staging is mandatory
Routine Blood Tests in Asymptomatic Patients With Indolent Lymphoma Have Limited Ability to Detect Clinically Significant Disease Progression
OX40+ T lymphocytes and IFN-γ are associated with American tegumentary leishmaniasis pathogenesis LinfĂłcitos T OX40+ e IFN-γ estĂŁo associados com a patogĂȘnese da leishmaniose tegumentar americana
BACKGROUND: Leishmaniases are zoonoses considered a public health problem, representing a complex group of diseases with a broad clinical spectrum and epidemiological diversity. Leishmaniasis is caused by several species of protozoa of the genus Leishmania. The evolution of the pathology and the resolution of the leishmaniasis are dependent mainly on the Leishmania species involved, although the cytokine profile plays an important role in the development of the immune response. OBJECTIVES: The purpose of our study was to evaluate the immune response of patients affected by lesions of cutaneous leishmaniasis by immunostaining of the OX40, CD20, IFN-γ and IL-4 proteins. METHODS: The tissue samples were collected from indolent skin ulcers confirmed as cutaneous leishmaniasis of 41 patients aged between six and 90 years. The lesions were submitted to OX40, CD20, INF-γ and IL-4 immunolabeling. RESULTS: We observed a statistically significant higher expression of IFN-γ compared with IL-4 (p=0.009). Besides, OX40 had higher expression when compared with CD20 (p<0.001). CONCLUSION: The present study indicates that the immune response in lesions of cutaneous leishmaniasis is associated with a healing process, which can be explained by the higher expression of IFN-γ when compared with IL4 protein levels.<br>FUNDAMENTOS: As leishmanioses sĂŁo zoonoses consideradas um problema de saĂșde pĂșblica, representando um grupo de doenças complexas, com uma diversidade de amplo espectro clĂnico e epidemiolĂłgico. A leishmaniose Ă© uma doença causada por vĂĄrias espĂ©cies de protozoĂĄrios do gĂȘnero Leishmania spp. A evolução da patologia e a resolução da leishmaniose sĂŁo dependentes principalmente da espĂ©cie de Leishmania envolvida; embora o perfil das citocinas tenha um importante papel no desenvolvimento da resposta imune. OBJETIVOS: Proporcionar mais conhecimentos sobre os eventos inflamatĂłrios na leishmaniose tegumentar atravĂ©s da avaliação da imunoexpressĂŁo de OX40, CD20, IFN-γ e IL-4. MĂTODOS: Foram coletadas amostras de tecido de 41 pacientes, com idade variando entre 6 a 90 anos, com Ășlceras indolentes na pele confirmados atravĂ©s de exames de diagnĂłstico como leishmaniose tegumentar. As lesĂ”es foram submetidas a imunomarcação das proteĂnas OX40, CD20, IFN-γ e IL-4. RESULTADOS: Observamos uma maior expressĂŁo de IFN-γ em comparação com IL-4, com diferenças estatisticamente significativa (p = 0,009). AlĂ©m disso, OX40 tinha maior expressĂŁo quando comparada com IL-4 (p <0,001). CONCLUSĂO: O presente estudo indica que a resposta imune nas lesĂ”es de LTA estĂĄ associada a um processo de cura, que pode ser explicado pela maior expressĂŁo de IFN-γ quando comparadas com os nĂveis de IL-4