7 research outputs found

    Biomarcadores en líquido cefalorraquideo en perros con meningoencefalitis de origen desconocido. Valor pronóstico

    Get PDF
    Las meningoencefalitis de origen desconocido son unas de las enfermedades inflamatorias del sistema nervioso central más frecuentes en perros. Los objetivos de este trabajo han consistido en identificar los factores que puedan tener alguna influencia en el pronóstico y supervivencia de perros con esta enfermedad, así como intentar establecer qué concentraciones de lactato, tanto sanguíneo como en líquido cefalorraquídeo, pueden ser determinantes en el pronóstico. Para ello, se ha realizado un estudio clínico prospectivo en 45 perros con esta patología y, como grupo control, 11 perros con epilepsia idiopática. Se ha determinado si existe relación entre la evolución de la enfermedad y la supervivencia con diferentes factores: raza, peso, sexo, edad, signos clínicos, hallazgos de resonancia magnética, análisis sanguíneo, análisis de líquido cefalorraquídeo y tratamientos recibidos previos y posteriores al diagnóstico. También se han estudiado los principales biomarcadores en líquido cefalorraquídeo: lactato y otros metabolitos analizados mediante espectroscopia por resonancia magnética nuclear realizada a través de la determinación del hidrógeno..

    Clinical signs, diagnostic imaging and histopathology in a dog with granulomatous meningoencephalitis manifested as a polyneuropathy

    Get PDF
    An 11-year-old, female, neutered labrador retriever with a history of chronic and progressive right hindlimb lameness and facial asymmetry was referred for brain and lumbosacral magnetic resonance imaging and cerebrospinal fluid analysis. Multifocal non-enhancing T2-weighted images of hyperintense lesions were observed in the caudate nuclei and medulla oblongata. The right oculomotor nerve was markedly enlarged and showed marked enhancement on T1-weighted images after contrast injection, and there was diffuse enlargement of the sciatic and femoral nerves in the right hindlimb. Cerebrospinal fluid analysis showed a mixed pleocytosis. Histopathology revealed granulomatous inflammation affecting the brain, oculomotor and pelvic limb nerves, consistent with a diagnosis of granulomatous meningoencephalomyelitis

    Survival of dogs with pituitary‐dependent hyperadrenocorticism treated twice daily with low doses of trilostane

    Get PDF
    Background Twice daily low trilostane doses have proven to be effective to manage canine Cushing's syndrome. However, survival and prognostic factors in dogs treated with this protocol have not been evaluated. The aim of the study was to evaluate survival and prognostic factors, including systolic blood pressure (SBP) at diagnosis, in dogs with pituitary-dependent hypercortisolism (PDH) treated with low trilostane doses. Methods Medical records of 91 dogs newly diagnosed with PDH initially treated with 0.2–1.1 mg/kg of trilostane twice daily were retrospectively included. Survival times were calculated using the Kaplan–Meier estimator. Univariable and multivariable analysis were performed using the Cox proportional hazard regression analysis. Results Overall, median survival was 998 days (range 26–1832 days, 95% confidence interval = 755–1241 days). In the multivariable analysis, age (hazard ratio [HR] = 1.337, p < 0.001), presence of calcinosis cutis (HR = 5.271, p < 0.001), body condition score (BCS) ≤3/9 (HR = 8.100, p < 0.001) and higher platelet count (HR = 1.002, p = 0.022) were negatively correlated with survival. SBP was not associated with survival. Conclusions Low-dose trilostane treatment twice daily provides slightly longer survival than previously reported for dogs with PDH treated once or twice daily at higher doses. Older age, presence of calcinosis cutis, low BCS and higher platelet count, but not systemic hypertension, are predictive of poorer prognosis in dogs with PDH

    Interim report on the archaeofaunal study of the late antiquity settlement of El Castillón (SANTA EULALIA DE TÁBARA, ZAMORA)

    Get PDF
    [ES] El poblado amurallado de El Castillón (Zamora) se sitúa en una cima amesetada sobre el curso medio del río Esla. En él se han documentado diferentes estructuras (de hábitat, de almacenamiento, de trabajo del metal), que se ponen en relación con diferentes ocupaciones que tuvieron lugar entre los siglos V y VI d. C. Asociadas a estas ocupaciones se han clasificado un gran cantidad de restos faunísticos (fundamentalmente de caprino y de porcino, pero también, aves, peces, moluscos, etc.) a partir de los cuales se ofrece una primera aproximación sobre las estrategias de subsistencia de los habitantes del poblado.[EN] The walled settlement of El Castillón (Zamora) is located on a plateau overlooking the middle course of the River Esla. The different structures documented (houses, storage and metal workshops) have been associated with occupations between the fifth and sixth centuries AD. A large number of faunal remains have been classified in connection with these occupations (mainly caprines and swine, but also fowl, fish, molluscs, etc.) and based on these a first approach is made to the subsistence strategies of the inhabitants of the settlement
    corecore