The Spitzer Microlensing Program As A Probe For Globular Cluster Planets: Analysis Of Ogle-2015-BLG-0448

The microlensing event OGLE-2015-BLG-0448 was observed by Spitzer and lay within the tidal radius of the globular cluster NGC 6558. The event had moderate magnification and was intensively observed, hence it had the potential to probe the distribution of planets in globular clusters. We measure the proper motion of NGC 6558 (${{\boldsymbol{\mu }}}_{\mathrm{cl}}(N,E)=(+0.36\pm 0.10,+1.42\pm 0.10)\;{\rm{mas}}\;{{\rm{yr}}}^{-1}$) as well as the source and show that the lens is not a cluster member. Even though this particular event does not probe the distribution of planets in globular clusters, other potential cluster lens events can be verified using our methodology. Additionally, we find that microlens parallax measured using Optical Gravitational Lens Experiment (OGLE) photometry is consistent with the value found based on the light curve displacement between the Earth and Spitzer

Blimp-1 functions as a molecular switch to prevent inflammatory activity in Foxp3⁺ ROR gamma t⁺regulatory T cells.

Foxp3(+) regulatory T cells (Treg) are essential modulators of immune responses, but the molecular mechanisms underlying their function are not fully understood. Here we show that the transcription factor Blimp-1 is a crucial regulator of the Foxp3(+)ROR gamma t(+) Treg subset. The intrinsic expression of Blimp-1 in these cells is required to prevent production of Th17-associated cytokines. Direct binding of Blimp-1 to the II17 locus in Treg is associated with inhibitory histone modifications but unaltered binding of ROR gamma t. In the absence of Blimp-1, the II17 locus is activated, with increased occupancy of the co-activator p300 and abundant binding of the transcriptional regulator IRF4, which is required, along with ROR gamma t, for IL-17 expression in the absence of Blimp-1. We also show that despite their sustained expression of Foxp3, Blimp-1(-/-) ROR gamma t(+)IL-17-producing Treg lose suppressor function and can promote intestinal inflammation, indicating that repression of Th17-associated cytokines by Blimp-1 is a crucial requirement for ROR gamma t(+) Treg function

Environmental justice in Cuba

'Environmental justice' refers to the human right to a healthy and safe environment, a fair share of natural resources, access to environmental information and participation in environmental decision-making. Some analysts have argued that environmental justice is undermined by the political economy of capitalism. This paper builds on this analysis by evaluating the environmental justice situation in Cuba, a country where there is little capitalist influence. Evidence is based on participant observation and interviews in Cuba, as well as secondary quantitative data. The research findings suggest that Cuba fares relatively well in terms of environmental justice, but still faces a number of challenges regarding the quality of its environment and some aspects of the environmental decision-making process. However, many of its ongoing problems can be attributed to global capitalist pressures. © The Author(s), 2011

A super-Jupiter orbiting a late-type star:a refined analysis of microlensing event OGLE-2012-BLG-0406

We present a detailed analysis of survey and follow-up observations of microlensing event OGLE-2012-BLG-0406 based on data obtained from 10 different observatories. Intensive coverage of the light curve, especially the perturbation part, allowed us to accurately measure the parallax effect and lens orbital motion. Combining our measurement of the lens parallax with the angular Einstein radius determined from finite-source effects, we estimate the physical parameters of the lens system. We find that the event was caused by a 2.73 ± 0.43 M J planet orbiting a 0.44 ± 0.07 M ☉ early M-type star. The distance to the lens is 4.97 ± 0.29 kpc and the projected separation between the host star and its planet at the time of the event is 3.45 ± 0.26 AU. We find that the additional coverage provided by follow-up observations, especially during the planetary perturbation, leads to a more accurate determination of the physical parameters of the lens.</p