Service-Channel Fit Conceptualization and Instrument Development - A Mixed Methods Study in the Context of Electronic Banking

Electronically mediated self-service technologies in the banking industry have impacted the way banks service consumers. Despite a large body of research on electronic banking channels, no study has been undertaken to empirically explore the fit between electronic banking channels and banking services. To address this gap, we developed and validated a service-channel fit conceptualization and an associated survey instrument. We applied a mixed methods approach and initially investigated industry experts’ perceptions regarding the concept of ‘service-channel fit’ (SCF). The findings demonstrated that the concept was highly valued by bank managers. Next, we developed an instrument to measure the perceived service-channel fit of electronic banking channels. The instrument was developed using expert rounds and two pretests involving approximately 300 consumers in New Zealand. Drawing on IS alignment literature, we created a parallel instrument allowing us to calculate SCF across three unique fit dimensions, including service complexity-channel fit, service importance-channel fit, and service routineness-channel fit. To explore the nomological validity of the SCF construct, we linked SCF to customers’ intention to use a specific channel for a particular banking task. We tested our model with data from 340 consumers in New Zealand using Internet banking applications for two different banking tasks. The results of our study have theoretical and practical implications for how clients should be serviced through electronically mediated Banking channels

The Sun also Sets: Ending the Life of a Software Product

Abstract. Sunsetting a software product is a painful and frustrating process, whether it happens in times of crisis or in an organized and planned manner. It is surprising that little information is available on how to perform sunsetting and it appears to be a blind spot in software product management literature. This paper describes the sunsetting method and provides practitioners with a welldefined process of how software products must be taken out of development, maintenance, and finally use. With the sunsetting method, product managers will have as little trouble as possible based on the experiences of others. The process description is elaborated using a method description. Furthermore, three retrospective case studies have been conducted to evaluate the method

Dissecting TSC2-mutated renal and hepatic angiomyolipomas in an individual with ARID1B-associated intellectual disability

Background Several subunits of the SWI/SNF chromatin remodeling complex are implicated in both cancer and neurodevelopmental disorders (NDD). Though there is no clinical evidence for an increased tumor risk in individuals with NDDs due to germline mutations in most of these genes so far, this has been repeatedly proposed and discussed. A young woman with NDD due to a de novo mutation in ARID1B now presented with a large renal (> 19 cm in diameter) and multiple hepatic angiomyolipomas (AMLs) but no other signs of tuberous sclerosis complex. Methods We analyzed tumor and healthy tissue samples with exome and panel sequencing. Results Additionally to the previously known, germline ARID1B variant we identified a post-zygotic truncating TSC2 variant in both renal and hepatic AMLs but not in any of the healthy tissues. We did not detect any further, obvious tumor driver events. The identification of a passenger variant in SIPA1L3 in both AMLs points to a common clonal origin. Metastasis of the renal AML into the liver is unlikely on the basis of discordant histopathological features. Our findings therefore point to very low-grade mosaicism for the TSC2 variant, possibly in a yet unknown mesenchymal precursor cell that expanded clonally during tumor development. A possible contribution of the germline ARID1B variant to the tumorigenesis remains unclear but cannot be excluded given the absence of any other evident tumor drivers in the AMLs. Conclusion This unique case highlights the blurred line between tumor genetics and post-zygotic events that can complicate exact molecular diagnoses in patients with rare manifestations. It also demonstrates the relevance of multiple disorders in a single individual, the challenges of detecting low-grade mosaicisms, and the importance of proper diagnosis for treatment and surveillance

Diverse molecular causes of unsolved autosomal dominant tubulointerstitial kidney diseases

Autosomal Dominant Tubulointerstitial Kidney Disease (ADTKD) is caused by mutations in one of at least five genes and leads to kidney failure usually in mid adulthood. Throughout the literature, variable numbers of families have been reported, where no mutation can be found and therefore termed ADTKD-not otherwise specified. Here, we aim to clarify the genetic cause of their diseases in our ADTKD registry. Sequencing for all known ADTKD genes was performed, followed by SNaPshot minisequencing for the dupC (an additional cytosine within a stretch of seven cytosines) mutation of MUC1. A virtual panel containing 560 genes reported in the context of kidney disease (nephrome) and exome sequencing were then analyzed sequentially. Variants were validated and tested for segregation. In 29 of the 45 registry families, mutations in known ADTKD genes were found, mostly in MUC1. Sixteen families could then be termed ADTKD-not otherwise specified, of which nine showed diagnostic variants in the nephrome (four in COL4A5, two in INF2 and one each in COL4A4, PAX2, SALL1 and PKD2). In the other seven families, exome sequencing analysis yielded potential disease associated variants in novel candidate genes for ADTKD; evaluated by database analyses and genome-wide association studies. For the great majority of our ADTKD registry we were able to reach a molecular genetic diagnosis. However, a small number of families are indeed affected by diseases classically described as a glomerular entity. Thus, incomplete clinical phenotyping and atypical clinical presentation may have led to the classification of ADTKD. The identified novel candidate genes by exome sequencing will require further functional validation

Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes

Across multiancestry groups, we analyzed Human Leukocyte Antigen (HLA) associations in over 176,000 individuals with Parkinson’s disease (PD) and Alzheimer’s disease (AD) versus controls. We demonstrate that the two diseases share the same protective association at the HLA locus. HLA-specific fine-mapping showed that hierarchical protective effects of HLA-DRB1*04 subtypes best accounted for the association, strongest with HLA-DRB1*04:04 and HLA-DRB1*04:07, and intermediary with HLA-DRB1*04:01 and HLA-DRB1*04:03. The same signal was associated with decreased neurofibrillary tangles in postmortem brains and was associated with reduced tau levels in cerebrospinal fluid and to a lower extent with increased Aβ42. Protective HLA-DRB1*04 subtypes strongly bound the aggregation-prone tau PHF6 sequence, however only when acetylated at a lysine (K311), a common posttranslational modification central to tau aggregation. An HLA-DRB1*04-mediated adaptive immune response decreases PD and AD risks, potentially by acting against tau, offering the possibility of therapeutic avenues

Managing software platforms and ecosystems

We are happy to introduce to you the "Managing Software Platforms and Ecosystems" special issue of IEEE Software. This special issue is characterized by contributions from diverse theoretical fields, such as computer science, information science, and economics, with research applied in practical settings in software-intensive business. It is an overview of the current state of research and illustrates some of the largest innovations in the field as well as the gaps for future research

Managing the Technology Acquisition Integration Paradox at SAP

In this paper, we report on a novel approach developed by SAP AG, the German enterprise software company, for managing the integration of acquisitions of companies to access innovative technologies and related capabilities: the Product Council approach. The value of the Product Council approach rests in ensuring critical speed while not compromising accuracy in the integration process. For SAP, the Product Council became a vital component in its technology acquisition capability that allows the company to retain its technological edge in the hypercompetitive software industry

Why don´t they join? Analyzing the Nature and Consequences of Complementors´ Costs in Platform Ecosystems

Platforms enable third-parties to develop new software artefacts like applications and become the locus of digital innovation. Prior studies have mainly focused on the benefits that initially motivate external complementors to join an ecosystem. However, little is known about the costs that are associated with this choice and how such costs actually influence the decision to interrelate with a platform owner. We develop the overarching idea that the complementor´s costs are mainly influenced by the interplay of the micro-architecture of single extensions and control modes applied to govern the ecosystem. The purpose of our research is therefore to shed light on the nature of complementors’ costs on the micro-level of transactions between the platform owner and the complementor and their effects on the intention to join an ecosystem. Using data from a quantitative survey among complementors of five leading platforms in the Enterprise Application Software industry hypothesized relationships are tested