Genetic evaluation of AMPD1, CPT2, and PGYM metabolic enzymes in patients with chronic fatigue syndrome

Chronic fatigue syndrome (CFS) is a disease that can seriously impair one’s quality of life; patients complain of excessive fatigue and myalgia following physical exertion. This disease may be associated with abnormalities in genes affecting exercise tolerance and physical performance. Adenosine monophosphate deaminase (AMPD1), carnitine palmitoyltransferase II (CPT2), and the muscle isoform of glycogen phosphorylase (PYGM) genes provide instructions for producing enzymes that play major roles in energy production during work. The aim of this study was to look for evidence of genotypeassociated excessive muscle fatigue. Three metabolic genes (AMPD1, CPT2, and PYGM) were therefore fully sequenced in 17 Italian patients with CFS. We examined polymorphisms known to alter the function of these metabolic genes, and compared their genotypic distributions in CFS patients and 50 healthy controls using chi-square tests and odds ratios. One-way analysis of variance with F-ratio was carried out to determine the associations between genotypes and disease severity using CF scores. No major genetic variations between patients and controls were found in the three genes studied, and we did not find any association between these genes and CFS. In conclusion, variations in AMPD1, CPT2, and PGYM genes are not associated with the onset, susceptibility, or severity of CFS

Outcomes of atopic dermatitis treatment in children using Levocetirizine hydrochloride

В статье дана характеристика препарата L-цет — представителя ІІІ поколения антигистаминных препаратов, содержащего левовращающий изомер цетиризина. Приведены результаты лечения детей с атопическим дерматитом с использованием препарата L-цет, свидетельствующие о его высокой эффективности и безопасности.У статті надано характеристику препарату L-цет — представника ІІІ покоління антигістамінних препаратів, що містить лівообертаючий ізомер цетиризину. Наведені результати лікування дітей з атопічним дерматитом із використанням препарату L-цет, що свідчать про його високу ефективність та безпеку.The article provides a description of L-cet – кepresentative third-generation antihistamines containing levorotatory isomer of cetirizine. Outcomes of treatment of children with atopic dermatitis using L-cet showing its high efficiency and safety are given