134 research outputs found
Redesigning Human Resource Management System through Cloud Computing: A Strategic Approach
Cloud computing is enabling human resource (HR) management functions to strategically integrate into business operations. Its acting as a game changer for HR amid intense competition to survive and grow. Digital disruption, transformation, agility has set the new benchmarks for organizations to automate and redesign their functions. Cloud Computing offers HR a completely new dimension with cloud centric benefits like reduction in communication gap, increased organizational excellence, effective talent strategies, data driven decision making, and supporting revenue in organizations. Cloud Computing has the right capability to redesign major HR functions with agility to match the changing requirements of business, automating transactional activities, smarter decision making and meeting the business expectations. Use of HR cloud in organization can result into structural benefits beyond technological advancements. Cloud HR gives organizations flexibility of location, prompt information processing, effective use of data analytics and strategic decision making. This paper discusses ways through which cloud computing could be integrated into HR functions. An analysis on applications of cloud computing in human resource areas with their outcomes is also presented in this paper. A brief note on future prospects of cloud computing in HRM is also discussed
Role of Various Mediators in Inflammation of Asthmatic Airways
The degree of airway inflammation is directly related to asthma severity and associated hyper-responsiveness. Airway inflammation is categorized into three types: (a) acute asthmatic inflammation featured by early recruitment of cells into the airways, (b) subacute asthmatic inflammation involving activation of recruited cells in continual inflammation, and (c) chronic inflammation characterized by cellular damage. T-helper lymphocytes, the key factor in the pathogenesis of bronchial asthma, induce B cells to synthesize and secrete IgE through production of IL-4 and induce eosinophil-mediated inflammation. Mediators such as histamine, PG, leukotrienes, and kinins contract airway smooth muscle, increase microvascular leakage, increase airway mucus secretion, and attract other inflammatory cells into airway epithelia that initiate mucociliary clearance signaling pathways through special Toll-like receptor 4 expressed on epithelial cells activated by allergic and infectious triggers. These cells form barrier against mechanical stress, oxidant stress, allergens, pollutants, infectious agents, and leakage of endogenous solutes. Various adhesion molecules and costimulatory factors also promote infiltration of inflammatory cells at the site of inflammation
Improving Physicochemical Properties of Repaglinide Through Pharmaceutical Adduct Formation
Background: Many formulation strategies are presently in development in pharmaceutical industry. However, the formation of pharmaceutical adducts is considered to be the most appropriate technique for improving the drug solubility and dissolution as no chemical bond changes are involved in this technique.Purpose: This technique is highly used for compounds which are not able to give viable formulation products with standard techniques such as salt formation and polymorph generation. In the present study, this method is applied to repaglinide, which is an hypoglycemic agent, with compromised solubility. Methods: The adducts were prepared by slow evaporation method and characterized using DSC, FTIR and PXRD studies. The solubility and dissolution studies were carried out to determine the increased solubility of drug in adducts. The drug amount interacted with coformers has also been determined. Results: The present study demonstrates the improvement in solubility and thus dissolution of repaglinide in adducts.Conclusion: The adducts formed in the present study can be further exploited to prepare formulation of repaglinide adducts with better physicochemical characteristics
Aesthetics of Poetry and Postmodernist Poets: A Review
Postmodernism is a period in which multiple modes or versions of different poetries exist and flourish. Poetry produced in the postmodern era and has an extremely solid nearness in cafes, bars, and even clubs, fundamentally outperforming its more conventional settings and areas. Poetry is becoming ever more synonymous with testing in English schools. poetry is not by learning the rules of scansion, or studying prosody and other theoretical aspects of poetry, although this is important, but by imitation. And what the poet imitates in the poets that he admires is the sound of the poetry, its rhythms, rhyme schemes, patterns, etc., not the lexical meanings of the words. Using the same words as the poets one admires would constitute plagiarism, not imitation, although one may certainly make allusions to other poems by means of what is sometimes called “poetic license”. poetry is cast as unstable and unreliable but simultaneously inescapable; language is both captor and captive .Poetry study at GCSE level could become a limited and controlled experience, restricted to the confines of the classroom and the pages of exam board anthologies. In this work, we have studied a theory of different poets in view of the aesthetic content of poetry. These poets are exceptionally dynamic and their poetries are different from the theories of art and all other poetries. The industriousness of the expository strategies of aesthetic formalism close by the more up to date scholarly apparatuses of basic hypothesis and social feedback has been examined. They are very active, leading tertulias, engaging with poetry readings and performances in literary and non-literary circles, and endorsing verse on the internet, with the result that the genre is now more open and available to the general public than ever before. For the Transcendentalists all true poets are “children of music”. 
Performance Appraisal in the Era of New Normal
Performance Appraisal is the process of assessing the accomplishments of workforce & to acknowledge their capabilities for facilitating development. Performance evaluation is one of the areas in Human resource management which is considerably affected by the spread of pandemic severe acute respiratory syndrome corona virus 2. This virus outbreak posed new challenges for the companies across the globe. As a result in order to tackle this uncertainty various organizations have taken measures to cut down the expenses like deferment in the appraisal cycle or for muted salary increments. Thus one of the objectives of this paper is to study the impact of Covid -19 on performance appraisal of employees. Further this pandemic is equally challenging for the managers also. As social distancing and working remotely have become a new normal, employees work remotely from each other and from managers, and this will be more common in the future. Managers are now searching for new ways to ‘do visibility’ without always being physically present. It has also become the vital demand of the situation as managers must be aware of the circumstances in which employees are working in. Therefore another objective of this paper is to suggest an approach to manage the performance evaluations of remote working employees. It is recommended that managers should adopt the choice based approach for performance evaluation instead of control based approach. The review is formed on articles and reports from various internet sources and journals. Further some ways of managing the performance assessment of remotely working employees and scope for the future are also discussed
PHYSICOCHEMICAL CHARACTERIZATION AND EVALUATION OF TELMISARTAN: HYDROXYPROPYL-β-CYCLODEXTRIN: TWEEN 80 INCLUSION COMPLEX
Objective: The present work was aimed to study the effect of the ternary component on complexation efficiency of cyclodextrins towards telmisartan which is a poorly soluble anti-hypertensive agent.Methods: The elucidation of inclusion complexation of telmisartan (TEL) with hydroxypropyl-β-cyclodextrin (HP-β-CD) in the presence and absence of tween 80 was done by investigating their interactions in solid and solution state. The solid state characterization was performed using differential scanning calorimetry (DSC), powder X-ray diffraction studies (PXRD) fourier transform infra-red spectroscopy (FTIR) studies. The host guest stoichiometry was confirmed in solution state by proton nuclear magnetic resonance (1HNMR) and solution calorimetry studies. The improvement in solubility was evaluated through dissolution studies, which was further confirmed by in vivo studies.Results: In solution state, the phase solubility studies indicated 1:1 stoichiometry between TEL and HP-β-CD both in presence and absence of tween 80. The NMR and molecular modelling studies indicated the insertion of N-methyl benzimidazole and biphenyl carboxylate regions of TEL into HP-β-CD cavity suggesting the coexistence of two 1:1 complexes in equilibrium with each other. The stability constants, K1 (imidazole region of TEL-CD) and K2 (biphenyl acetic acid region of TEL-CD), were enhanced in the presence of tween 80 as evident by the higher value of stability constants. Efficacy of ternary complex was established by a significant decrease in the systolic blood pressure of deoxycorticosterone acetate (DOCA) induced hypertensive rats.Conclusion: It can be concluded that solubility of TEL was increased by encapsulation with HP-β-CD. Tween 80 further increased the complexation efficiency and decreased the bulk of cyclodextrin
Ameliorative Potential of Aminophylline In Restrain Stress Induced Behavioural and Biochemical Alterations
This study is designed to investigate the attenuating prospective of aminophylline in immobilization stress generated behavioural changes in rats. Animals were exposed to restrain stress before being subjected to varying doses of aminophylline (1mg/kg, 2mg/kg and 4mg/kg). Behavioural changes were analyzed to assess the intensity and the degree of the stress, by estimating the changes in the exploratory behaviour, spontaneous activity and social behaviour using various paradigms. As a consequence of stress, the behavioral patterns so changed were assessed in the terms of changes in the locomotor activity, number of head dips and increased avoidance behaviour. Aminophylline (4mg/kg) modulated the stress produced changes in the behaviour and oxidative stress generated biochemical alterations in a significant manner (p<0.001). The results so obtained suggest that upon exposure to stress, animal behavioural patterns, biochemical markers levels changed and these changes wereefficiently modulated by aminophylline at therapeutic doses
Bio-Functional Aspects of Grape Seeds-A Review
Grapes are one of the most widely consumed fruits all over the world and have considerable importance for their medicinal and nutritive value for thousand of years. Grapes are rich in polyphenols and 60-70 % of grapes polyphenols exist in grape seeds. The seeds contain lipid, proteins, carbohydrates and 5-8 % polyphenolic compounds. The phenolic compounds present in grape seeds are flavonoids including gallic acid, flavan-3-ol monomers and their oligomeric and polymeric derivatives (procyanidins). The most abundant flavan-3-ol monomers isolated from grape seeds are Catechin, epicatechin, epicatechin-3-O-gallate, and epigallocatechin-3-O-gallate. Three novel flavan oxidative derivatives named viniferones A, B and C have also been isolated from grape seeds. The grape seeds are chiefly known for their significant antioxidant properties. Scientific studies have claimed that the antioxidant potential of grape seeds proanthocyanidins is 20 times greater than vitamin E and 50 times greater than vitamin C. Grape seeds polyphenolic (Proanthocyanidin) extract have been marketed in France for decades as treatment for venous and capillary disorders (e.g., retinopathies, venous insufficiency, and vascular fragility. Recent studies have shown that procyanidins in grape seeds possess anti-inflammatory, anti-arthritic, anti-allergic effects and prevent heart diseases and skin aging. The high purity grape seed extract should contain polyphenols NLT 95% and monomers NLT 10%; and the grape seed extract with ordinary quality should have a procyanidolic value NLT 95%, and monomer NLT 6%.Keywords: Grapes, Grape seeds, Polyphenols, procyanidins, viniferones
Characterisation and evaluation of pharmaceutical solvates of Atorvastatin calcium by thermoanalytical and spectroscopic studies
BACKGROUND: Atorvastatin calcium (ATC), an anti-lipid biopharmaceutical class II drug, is widely prescribed as a cholesterol-lowering agent and is presently the world’s best-selling medicine. A large number of crystalline forms of ATC have been published in patents. A variety of solid forms may give rise to different physical properties. Therefore, the discovery of new forms of this unusual molecule, ATC, may still provide an opportunity for further improvement of advantageous properties. RESULTS: In the present work, eight new solvates (Solvate I-VIII) have been discovered by recrystallization method. Thermal behaviour of ATC and its solvates studied by DSC and TGA indicate similar pattern suggesting similar mode of entrapment of solvent molecules. The type of solvent present in the crystal lattice of the solvates is identified by GC-MS analysis and the stoichiometric ratio of the solvents is confirmed by (1)HNMR. The high positive value of binding energy determined from thermochemical parameters indicates deep inclusion of the solvent molecules into the host cavity. The XRPD patterns point towards the differences in their crystallanity, however, after desolvation solvate II, III, IV, V and VIII transform to isostructral amorphous desolvated solvates. The order of crystallinity was confirmed by solution calorimetric technique as the enthalpy of solution is an indirect measure of lattice energy. All the solvates behaved endothermically following the order solvate-VIII (1-butanol solvate) < solvate-I (isoproplyate) < solvate-V (methanol solvate) < solvate-III (ethonalate) < solvate-VI (acetone ethanol solvate) < solvate-IV (t-butanol solvate) < solvate-II (THF solvate) < solvate-VII (mixed hemi-ethanol hydrate). The positive value of the heat capacity of the solvate formation provides information about the state of solvent molecules in the host lattice. The solvents molecules incorporated in the crystal lattice induced local chemical environment changes in the drug molecules which are observed in (13)CP/MAS NMR spectral changes. CONCLUSIONS: Aqueous solubility of solvate-VIII was found to be maximum, however, solvate-I and VIII showed better reduction in total cholesterol and triglyceride levels as compared to atorvastatin against triton-induced dyslipidemia
Educating the Ethical Business Student: Enhancing our Mission by Embracing Fair Trade College Status
- …