Water-Soluble Photoluminescence <i>On–Off–On</i> Probe for Speedy and Selective Detection of Fluoride Ions

A CdTe QDs based new type of water-soluble switch <i>on–off–on</i> photoluminescence (PL) probe has been developed for specific detection of fluoride ions (F^–). Europium ions (Eu³⁺) stabilized by the carboxylic groups of 3-mercaptopropanoic acid (MPA) capped CdTe QDs result in quenching of PL (switch <i>off</i>) of QDs. PL is regained (switch <i>on</i>) with the addition of F^– due to the formation of EuF₃ as Eu³⁺ has higher bonding affinity with F^– compared to carboxylic acid groups. The quenching of the PL property of CdTe-MPA QDs toward Eu³⁺ and its regeneration in the presence of F^– is highly selective, sensitive (detection limit 5 ppm to 75 ppm), and prompt (less than 10 s). The technique has been successfully applied for the detection of HF vapors, which is actually an important issue from the industrial perspective. To the best of our knowledge, this is the first report of the use of one step synthesized water-soluble 3-MPA capped CdTe QDs, as a rapid, efficient, and most importantly selective photoluminescence <i>on–off–on</i> probe for fluoride ion detection

Recent advances in delivering free or nanoencapsulated <i>Curcuma</i> by-products as antimicrobial food additives

Food commodities are often contaminated by microbial pathogens in transit or during storage. Hence, mitigation of these pathogens is necessary to ensure the safety of food commodities. Globally, researchers used botanicals as natural additives to preserve food commodities from bio-deterioration, and advances were made to meet users’ acceptance in this domain, as synthetic preservatives are associated with harmful effects to both consumers and environments. Over the last century, the genus Curcuma has been used in traditional medicine, and its crude and nanoencapsulated essential oils (EOs) and curcuminoids were used to combat harmful pathogens that deteriorate stored foods. Today, more research is needed for solving the problem of pathogen resistance in food commodities and to meet consumer demands. Therefore, Curcuma-based botanicals may provide a source of natural preservatives for food commodities that satisfy the needs both of the food industry and the consumers. Hence, this article discusses the antimicrobial and antioxidant properties of EOs and curcuminoids derived from the genus Curcuma. Further, the action modes of Curcuma-based botanicals are explained, and the latest advances in nanoencapsulation of these compounds in food systems are discussed alongside knowledge gaps and safety assessment where the focus of future research should be placed.</p

sj-docx-1-jpc-10.1177_21501319231199014 – Supplemental material for The Use of Telemedicine to Improve Hypertension in an Urban Primary Care Clinic and Predictors of Improved Blood Pressure

Supplemental material, sj-docx-1-jpc-10.1177_21501319231199014 for The Use of Telemedicine to Improve Hypertension in an Urban Primary Care Clinic and Predictors of Improved Blood Pressure by Ajay Kerai, Namratha Meda, Khushboo Agarwal, Mohil Garg, Brototo Deb, Pooja Singh, Puneet Singla, Tareq Arar, Godwin Darko and Nnenna Oluigbo in Journal of Primary Care & Community Health</p

Synthesis, Structure–Activity Relationships, and Preclinical Evaluation of Heteroaromatic Amides and 1,3,4-Oxadiazole Derivatives as 5‑HT₄ Receptor Partial Agonists

Alzheimer’s disease (AD) is a neurodegenerative disorder that has a higher prevalence and incidence in people older than 60 years. The need for improved AD therapies is unmet as the current therapies are symptomatic with modest efficacy. Partial agonists of the 5-HT₄ receptor (5-HT₄R) offer both symptomatic and disease-modifying treatments as they shift amyloid-precursor-protein (APP) processing from the amyloidogenic pathway to the nonamyloidogenic pathway by activating the α-secretase enzyme. In addition, they also offer symptomatic treatment by increasing levels of the neurotransmitter acetylcholine in the brain. Because of this fascinating dual mechanism of action, several chemical scaffolds having 5-HT₄R pharmacophores were designed and evaluated. Most of the synthesized compounds showed potent in vitro affinities and in vivo efficacies. Upon analysis of focused structure–activity relationships, compound <b>4o</b> was identified as a potent 5-HT₄R partial agonist with favorable ADME properties and good in vivo efficacy. GR-125487, a selective 5-HT₄R antagonist, attenuated the activity of compound <b>4o</b> in the novel-object-recognition-test cognition model

Treatment initiation status of bacteriologically confirmed rifampicin sensitive TB cases.

<p>Treatment initiation status of bacteriologically confirmed rifampicin sensitive TB cases.</p

Mortality analysis stratified by treatment initiation of positive cases, age group, sex and past history of treatment.

<p>Mortality analysis stratified by treatment initiation of positive cases, age group, sex and past history of treatment.</p

Presumptive pediatric TB cases enrolled under the project and TB cases diagnosed on Xpert, stratified by age, gender, referring sector and prior history of TB treatment.

<p>Presumptive pediatric TB cases enrolled under the project and TB cases diagnosed on Xpert, stratified by age, gender, referring sector and prior history of TB treatment.</p

Incremental yields among first, second & third round Xpert testing.

<p>Incremental yields among first, second & third round Xpert testing.</p

Treatment outcome in rifampicin sensitive cases.

<p>Treatment outcome in rifampicin sensitive cases.</p

Comparison of Xpert and smear positivity in different types of specimen.

<p>Comparison of Xpert and smear positivity in different types of specimen.</p